English Journal

A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives.

Murata K, Hamada M, Sugimoto K, Nakano T.SourceFirst Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. atarum@clin.medic.mie-u.ac.jp
Journal of hepatology.J Hepatol.2007 Feb;46(2):322-9. Epub 2006 Nov 3.
BACKGROUND/AIMS: The aim of this study was to investigate the precise mechanism of liver failure by hydralazine derivatives, with special reference to liver regeneration failure.METHODS: Histone acetylation and proliferation of hepatocytes were evaluated by immunohistochemistry with anti-acetylated
PMID 17156885

DNA repair of hydrogen peroxide-induced damage in human lymphocytes in the presence of four antimutagens. A study with alkaline single cell gel electrophoresis (comet assay).

Gasiorowski K, Brokos B.SourceWrocław Medical University, Department of Basic Medical Sciences, Kochanowskiego 14, 51-601 Wrocław, Poland. kaz@basmed.am.wroc.pl
Cellular & molecular biology letters.Cell Mol Biol Lett.2001;6(4):897-911.
We assessed four antimutagenic compounds' influences on DNA repair in human lymphocytes exposed in vitro to hydrogen peroxide (20 microM, 5 min, at 4 degrees C). DNA damage and repair were estimated by means of alkaline single cell gel electrophoresis (comet assay). It was noticed that the enhanceme
PMID 11753436