酢酸トコフェロール、トコフェロール酢酸エステル

関: tocopherol、tocopherol calcium succinate、tocopherol nicotinate

WordNet

a salt or ester of acetic acid (同)ethanoate

PrepTutorEJDIC

酢酸(さくさん)塩;アセテート(酢酸人造絹糸)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/07 13:34:12」(JST)

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[Wiki en表示]

Tocopheryl acetate, also known as vitamin E acetate, is a common vitamin supplement with the molecular formula C₃₁H₅₂O₃ (for 'α' form). It is the ester of acetic acid and tocopherol (vitamin E). It is often used in dermatological products such as skin creams. Tocopheryl acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol and provides beneficial antioxidant effects.^[1]

Tocopheryl acetate is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life. It is believed that the acetate is slowly hydrolyzed once it is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.^[2]

References

^ Linus Pauling Institute Research Report: All About E
^ Beijersbergen van Henegouwen G, Junginger H, de Vries H (1995). "Hydrolysis of RRR-alpha-tocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo study with the rat)". J Photochem Photobiol B. 29 (1): 45–51. doi:10.1016/1011-1344(95)90251-1. PMID 7472802.

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English Journal

Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): formulation design and optimization studies.

Yang YT1, Di Pasqua AJ, Zhang Y, Sueda K, Jay M.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Nov;19(7):806-12. doi: 10.3109/10837450.2013.836216. Epub 2013 Sep 19.
The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit® RL PO and α-tocopherol. D-optimal mix
PMID 24047113

Dramatic solvent effect on the synergy between α-tocopherol and BHT antioxidants.

Marteau C1, Favier D2, Nardello-Rataj V3, Aubry JM4.
Food chemistry.Food Chem.2014 Oct 1;160:190-5. doi: 10.1016/j.foodchem.2014.03.070. Epub 2014 Mar 22.
During the DPPH scavenging assay carried out in non polar and non protic solvents, such as toluene, BHT regenerates α-tocopherol from tocopheryl radical, whereas in polar and protic solvents, like methanol, no regeneration is observed due to a fast electron transfer reaction from the tocopheryl rad
PMID 24799226

Characterization of antioxidant methylcellulose film incorporated with α-tocopherol nanocapsules.

Noronha CM1, de Carvalho SM2, Lino RC2, Barreto PL3.
Food chemistry.Food Chem.2014 Sep 15;159:529-35. doi: 10.1016/j.foodchem.2014.02.159. Epub 2014 Mar 12.
Biodegradable and antioxidant films based on methylcellulose (MC) and α-tocopherol nanocapsule suspension (NCs) were developed. MC and NCs films were prepared by a casting method in three different proportions. The mechanical, wettability, colour, light transmission, antioxidant and release charact
PMID 24767092

Japanese Journal

脂溶性ビタミンおよび関連物質のファージ不活化作用

村田晃,今津京子,酒井繁,徳永幸一,副島智子,宮田せつ子,本村芳子,香月圭子,森達也,加藤富民雄,神田康三
ビタミン 84(1), 1-6, 2010-01-25
… α-Tocopherol, phylloquinone and menaquinone inactivated all of the 9 phages examined. … Vitamin A acetate, retinol, retinal, ergocalciferol, ergosterol and cholecalciferol inactivated 5 phages. … α-Tocopherol, phylloquinone and menaquinone had great inactivating effects. … The mechanism of the phage-inactivating effect of α-tocopherol was investigated. …
NAID 110007521140

Antimicrobial Activity and Essential Oil Composition of a New T. argyrophyllum (C. Koch) Tvzel var. argyrophyllum Chemotype

Polatoglu Kaan,Demirci Fatih,Demirci Betül,Gören Nezhun,Can Baser Kemal Hüsnü
Journal of Oleo Science 59(6), 307-313, 2010
… argyrophyllum was characterized with camphor 29.7%, borneol 12.0%, 1,8-cineole 8.4% and bornyl acetate 6.1%. … However, the oils did not show any significant activity when compared to positive control α-tocopherol. …
NAID 130000253588

★リンクテーブル★

リンク元	「トコフェロール」「ビタミンE」「tocopherol calcium succinate」「酢酸トコフェロール」「tocopherol nicotinate」

「トコフェロール」

Tocopheryl acetate
Names
	IUPAC name [(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate
	Other names Tocopherol acetate; Vitamin E acetate
Identifiers
CAS Number	58-95-7 ;
3D model (Jmol)	Interactive image;
ChemSpider	77987 ;
ECHA InfoCard	100.000.369
PubChem CID	86472;
UNII	A7E6112E4N ;
	InChI InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1 Key: ZAKOWWREFLAJOT-CEFNRUSXSA-N ; InChI=1/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1 Key: ZAKOWWREFLAJOT-CEFNRUSXBQ ;
	SMILES O=C(Oc2c(c(c1O[C@](CCc1c2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)C)C ;
Properties
Chemical formula	C31H52O3
Molar mass	472.743 g/mol
Hazards
NFPA 704	1 1 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: tocopherol、tocopherol acetate、tocopherol nicotinate、tocopherol calcium succinate
化: ニコチン酸トコフェロール tocopherol nicotinate、コハク酸トコフェロールカルシウム tocopherol calcium succinate、[[]] tocopherol acetate
商: ベクタン、ユベラ、(トコフェロールニコチン酸エステル)ニコ; M.V.I.、M.V.I.-12キット、NEソフト、VEニコチネート、アゼプチン、アミノレバンEN配合、エセブロン、エパラ、エルネオパ1号輸液、エレンタールP乳幼児用配合、エレンタール配合、エンシュア・リキッド、オーツカＭＶ、ゲファルナート、ケントン、ダイメジン・マルチ、ツインラインNF配合、ツインライン配合、トコニジャスト、ナーセット配合、ニコ200ソフト、ニチEネート、ネオM.V.I.-9、ネオパレン1号輸液、ネオラミン・マルチＶ、ハイシップ、バナール、バナールＮ、パンビタン、ビタジェクト、ビタミンE、ビタミンＥ、ファンギゾン、フルカリック１号輸液、ベクタン、ヘパンED配合、ヘモナーゼ配合、マルタミン、ユベ-E、ユベラN、ラコールNF配合、ラコール配合、リバスタッチ、流動パラフィン.OI; ユベラ Juvela(錠,ビタミンAとの合剤)
関: ビタミンE vitamin E。その他の循環器官用薬

参考

ニコ200ソフトカプセル

http://www.info.pmda.go.jp/go/pack/2190006M2110_2_07/2190006M2110_2_07?view=body

「ビタミンE」

　　[★]

英: vitamin E V. E
同: トコフェロール tocopherol、トコトリエノール tocotrienol、酢酸トコフェロール tocopherol acetate、コハク酸トコフェロールカルシウム calcium tocopherol succinate
商: フェニルアラニン除去ミルク配合、ユベラ、ロイシン・イソロイシン・バリン除去ミルク配合
関: ビタミン

概念

脂溶性ビタミン
D-α-トコフェロール
抗酸化作用を有する。
脂質層のラジカルの捕捉。ここで消費されたビタミンEはビタミンCにより再生される。

(http://ja.wikipedia.org/wiki/%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3E)

臨床関連

欠乏

ビタミンE欠乏症

過剰

「tocopherol calcium succinate」

　　[★]

コハク酸トコフェロールカルシウム

関: tocopherol、tocopherol acetate、tocopherol nicotinate

「酢酸トコフェロール」

　　[★]

英: tocopherol acetate
関: トコフェロール、トコフェロール酢酸エステル、ビタミンE

「tocopherol nicotinate」

　　[★]

ニコチン酸トコフェロール

関: tocopherol、tocopherol acetate、tocopherol calcium succinate

[1] Linus Pauling Institute Research Report: All About E

[2] Beijersbergen van Henegouwen G, Junginger H, de Vries H (1995). "Hydrolysis of RRR-alpha-tocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo study with the rat)". J Photochem Photobiol B. 29 (1): 45–51. doi:10.1016/1011-1344(95)90251-1. PMID 7472802.

匿名

検索

案内

案内

tocopherol acetate