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tocainide hydrochloride

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「antiarrhythmic drug (trade name Tonocard) used to treat ventricular arrhythmias when less dangerous drugs have failed」

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  • N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels.
  • Muraglia M1, De Bellis M, Catalano A, Carocci A, Franchini C, Carrieri A, Fortugno C, Bertucci C, Desaphy JF, De Luca A, Conte Camerino D, Corbo F.
  • Journal of medicinal chemistry.J Med Chem.2014 Mar 27;57(6):2589-600. doi: 10.1021/jm401864b. Epub 2014 Mar 7.
  • On the basis of a 3D-QSAR study, a new generation of tocainide analogues were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. Data obtained by screening new compounds by means of Hille-Campbell Vaseline gap voltage-clamp recordings showed that the elongation of the
  • PMID 24568674
  • Species-dependent binding of tocainide analogues to albumin: Affinity chromatography and circular dichroism study.
  • Pistolozzi M1, Fortugno C2, Franchini C3, Corbo F3, Muraglia M3, Roy M4, Félix G4, Bertucci C5.
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 Jan 10. pii: S1570-0232(14)00009-9. doi: 10.1016/j.jchromb.2014.01.007. [Epub ahead of print]
  • A series of novel tocainide analogues were characterized for their HSA and RSA binding, by using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). In this HPLAC study, HSA and RSA were covalently immobilized to the silica matrix of HPLC columns, with a procedure th
  • PMID 24472243
  • Non-antiepileptic drugs for trigeminal neuralgia.
  • Zhang J1, Yang M, Zhou M, He L, Chen N, Zakrzewska JM.
  • The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4.
  • BACKGROUND: Trigeminal neuralgia was defined by the International Association for the Study of Pain as a sudden, usually unilateral, severe, brief, stabbing recurrent pain in the distribution of one or more branches of the fifth cranial nerve. Standard treatment is with anti-epileptic drugs. Non-ant
  • PMID 24297506


  • 67) 犬急性心筋梗塞巣に対するTocainideの効果 : 電気生理学的検討から(日本循環器学会 第81回北陸地方会)
  • Assay of tocainide enantiomers in plasma by solid-phase extraction and indirect chiral high-performance liquid chromatography after derivatization with (-)-menthyl chloroformate
  • Journal of chromatography. B, Biomedical applications 670(2), 243-249, 1995-08-18
  • NAID 10024549252
  • TocainideのNa電流抑制作用 : 日本循環器学会第59回中国・四国地方会
  • Japanese circulation journal 57(SupplementIII), 1068-1069, 1993-08-20
  • NAID 110002635022


tocainide /to·cai·nide/ (to-ka´nīd) an antiarrhythmic agent, used as the hydrochloride salt in the treatment of ventricular arrhythmias. tocainide [to-ka′nīd] an agent used as the hydrochloride salt in treatment of ventricular arrhythmias.
Synopsis: Tocainide1 is an antiarrhythmic drug structurally related to lignocaine with similar electrophysiological, haemodynamic and antiarrhythmic effects. In contrast to lignocaine (lidocaine) it i ... Synopsis: Tocainide 1 is an ...



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