tissue factor

出典: meddic

組織因子TFfactor IIICD142


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/09 17:00:01」(JST)

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英文文献

  • Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model.
  • Jian B, Yang S, Chaudry IH, Raju R.Author information Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.AbstractSevere hemorrhage leads to decreased blood flow to tissues resulting in decreased oxygen and nutrient availability affecting mitochondrial function. A mitoscriptome profiling study demonstrated alteration in several genes related to mitochondria, consistent with the mitochondrial functional decline observed after trauma hemorrhage (T-H). Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels. Our hypothesis was that mitochondrial function after T-H depends on SIRT1 activity. In this study, we evaluated the activity of SIRT1, a mitochondrial functional modulator, and the mitochondrial-glycolytic balance after T-H. We determined the changes in protein levels of pyruvate dehydrogenase kinase (PDK)-1 and nuclear c-Myc, peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and NF-E2-related factor (NRF)2 after T-H and after treatment with resveratrol or a combination of sirtinol (a SIRT1 inhibitor) and resveratrol. We have also tested the activity of mitochondrial complex 1. SIRT1 enzyme activity was significantly decreased after T-H, whereas resveratrol treatment restored the activity. We found elevated PDK1 and c-Myc levels and decreased PGC-1α, NRF2 and mitochondrial complex I activity after T-H. The reduced SIRT1 activity after T-H may be related to declining mitochondrial function, since resveratrol was able to reinstate SIRT1 activity and mitochondrial function. The elevated level of PDK1 (an inhibitor of pyruvate dehydrogenase complex) after T-H indicates a possible shift in cellular energetics from mitochondria to glycolysis. In conclusion, SIRT1 modulation alters left ventricular function after T-H through regulation of cellular energetics.
  • Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):10-6. doi: 10.2119/molmed.2013.00077.
  • Severe hemorrhage leads to decreased blood flow to tissues resulting in decreased oxygen and nutrient availability affecting mitochondrial function. A mitoscriptome profiling study demonstrated alteration in several genes related to mitochondria, consistent with the mitochondrial functional decline
  • PMID 24395567
  • Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice.
  • Aalapati S1, Ganapathy S, Manapuram S, Anumolu G, Prakya BM.Author information 1Department of Toxicology, International Institute of Biotechnology and Toxicology [IIBAT] , Chennai , India.AbstractMale CD1 mice were subjected to nose-inhalation exposure of CeO2 nanoparticles (NPs) for 0, 7, 14 or 28 days with 14 or 28 days of recovery time at an aerosol concentration of 2 mg/m(3). Markers of lung injury and pro-inflammatory cytokines (interleukin-1beta, tumour necrosis factor-alpha, interleukin-6 and macrophage inflammatory protein-2) in bronchoalveolar lavage fluid (BALF), oxidative stress in lungs, bio-accumulation, and histopathology of pulmonary and extrapulmonary tissues were assessed. BALF analysis revealed the induction of pulmonary inflammation, as evident by an increase in the influx of neutrophils with a significant secretion of pro-inflammatory cytokines that lead to generation of oxidative stress and cytotoxicity, as is evident by induction of lipid peroxidation, depletion of glutathione and increased BALF lactate dehydrogenase and protein. The histopathological examination revealed that these inhaled CeO2 NPs were located all over the pulmonary parenchyma, inducing a severe, chronic, active inflammatory response characterised by necrosis, proteinosis, fibrosis and well-formed discrete granulomas in the pulmonary tissue and tubular degeneration leading to coagulative necrosis in kidneys. Inductively coupled plasma optical emission spectrometer results showed a significant bio-accumulation of these particles in the pulmonary and extrapulmonary tissues, even after one month of post-inhalation exposure. Together, these findings suggest that inhalation exposure of CeO2 NPs can induce pulmonary and extrapulmonary toxicity.
  • Nanotoxicology.Nanotoxicology.2014 Nov;8(7):786-98. doi: 10.3109/17435390.2013.829877. Epub 2013 Aug 22.
  • Male CD1 mice were subjected to nose-inhalation exposure of CeO2 nanoparticles (NPs) for 0, 7, 14 or 28 days with 14 or 28 days of recovery time at an aerosol concentration of 2 mg/m(3). Markers of lung injury and pro-inflammatory cytokines (interleukin-1beta, tumour necrosis factor-alpha, interleuk
  • PMID 23914771
  • A murine model of airway fibrosis induced by repeated naphthalene exposure.
  • Aoshiba K1, Tsuji T2, Itoh M2, Semba S2, Yamaguchi K3, Nakamura H2, Watanabe H2.Author information 1Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Japan. Electronic address: kaoshiba@tokyo-med.ac.jp.2Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Japan.3Comprehensive and Internal Medicine, Tokyo Women's Medical University Medical Center East, Japan.AbstractThe airway epithelium serves as a biological barrier essential for host defense against inhaled pollutants. While chronic epithelial injury, commonly associated with chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome, often results in airway fibrosis, limited animal models of airway fibrosis have been established. Club cells (Clara cells) in the small airways represent an important population of epithelial progenitor cells and also the principal site of localization of the cytochrome P-450 monooxygenase system, which metabolically activates xenobiotic chemicals such as naphthalene by converting them to toxic epoxide intermediates. We hypothesized that repeated exposure to naphthalene may cause prolonged loss of club cells, triggering aberrant local epithelial repair mechanisms that lead to peribronchial fibrosis. We administered intraperitoneal injections of naphthalene to C57/BL6J mice once a week for 14 consecutive weeks. Repeated club cell injury caused by naphthalene triggered regional hyperproliferation of epithelial progenitor cells, while other regions remained denuded or squamated, resulting in fibroblast proliferation and peribronchial collagen deposition associated with upregulation of the fibrogenic cytokines transforming growth factor-β and connective tissue growth factor. The total collagen content of the lung assessed by measurement of the hydroxyproline content was also increased after repeated exposure to naphthalene. These results lend support to the relevance of repeated injury of airway epithelial cells as a trigger for resting fibroblast proliferation and airway fibrosis. This model of airway fibrosis is simple and easy to reproduce, and may be expected to advance our understanding of the pathogenesis and potential treatment of airway fibrotic disorders.
  • Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2014 Jul;66(4):169-77. doi: 10.1016/j.etp.2014.01.001. Epub 2014 Jan 28.
  • The airway epithelium serves as a biological barrier essential for host defense against inhaled pollutants. While chronic epithelial injury, commonly associated with chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome, often results in airway fibrosis, limited animal models o
  • PMID 24480153

和文文献

  • The Use of Bone Marrow Stromal Cells (Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells) for Alveolar Bone Tissue Engineering: Basic Science to Clinical Translation
  • Kagami Hideaki,Agata Hideki,Inoue Minoru,Asahina Izumi,Tojo Arinobu,Yamashita Naohide,Imai Kohzoh
  • Tissue
  • … Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. … Human bone marrow stromal cells (BMSCs) are the most commonly used cell source for bone tissue engineering. … Application of basic fibroblast growth factor helped to maintain the in vivo osteogenic ability of BMSCs. …
  • NAID 120005447068
  • Ki-67 is a strong prognostic marker of non-small cell lung cancer when tissue heterogeneity is considered
  • Tabata Kazuhiro,Tanaka Tomonori,Hayashi Tomayoshi,Hori Takashi,Nunomura Sayuri,Yonezawa Suguru,Fukuoka Junya
  • BMC Clinical Pathology 14(1), 23, 2014-05-13
  • … Cox multivariate analysis of Ki-67 showed that HS was an independent risk factor affecting overall survival. …
  • NAID 120005451798
  • CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes
  • Maeda-Uematsu Aya,Kubota Satoshi,Kawaki Harumi,Kawata Kazumi,Miyake Yoshiaki,Hattori Takako,Nishida Takashi,Moritani Norifumi,Lyons Karen M.,Iida Seiji,Takigawa Masaharu
  • Journal of Cellular Biochemistry 115(5), 854-865, 2014-05
  • … CCN2/connective tissue growth factor (CTGF) is a unique molecule that promotes both chondrocytic differentiation and proliferation through its matricellular interaction with a number of extracellular biomolecules. …
  • NAID 120005468290

関連リンク

rheumatoid factor (RF) antibodies directed against antigenic determinants on IgG molecules, found in the serum of about 80 per cent of patients with classic or definite rheumatoid arthritis; but in only about 20 per cent of patients with ...
組織因子(tissue factor: TF)は細胞膜結合型の1本鎖糖蛋白質で,外因系血液凝固反応の開始因子である.TFは細胞表面のリン脂質層上でⅦ因子または活性化Ⅶ(Ⅶa)因子と複合体を形成し,Ⅸ因子およびⅩ因子を活性化させ ...

関連画像

Tissue factor - wikidocEmerging roles of tissue factor in viral Factor vii; Proconvertina; Factor Estable Tissue FactorFibroblast growth factor receptor 2 File:Tissue factor.png - Wikipedia, the


★リンクテーブル★
先読みCD142
リンク元第VIII因子」「組織因子」「prothrombinase」「TF」「coagulation factor III
拡張検索tissue factor pathway inhibitor
関連記事factor」「fact」「tissue

CD142」

  [★]

Thromboplastin, Tissue factor
also Tissue factor


第VIII因子」

  [★]

factor VIII, FVIII
血漿トロンボプラスチン因子 plasma thromboplastin factor PTF
抗血友病グロブリン antihemophilic globulin、抗血友病因子A antihemophilic factor A platelet cofactor I、抗血友病因子
(オクトコグアルファ)コージネイト
(ルリオクトコグアルファ)アドベイト
クロスエイトコンコエイトコンファクト
血液凝固因子血友病
[show details]


存在部位

半減期

  • 12 hr

産生組織

  • 細網系?

肝以外で産生される凝固因子

座乗染色体

  • xq28

臨床関連


組織因子」

  [★]

tissue factor TF
第III因子factor III
血液凝固因子組織トロンボプラスチン


  • 組織で産生される
  • 糖タンパク質
  • 45kDa
  • 外因系カスケードの起点となる
  • 第VII因子を活性化し(第VIIa因子)、また複合体を形成して以下の反応を起こす
第X因子の活性化
第IX因子の活性化


prothrombinase」

  [★]

プロトロンビナーゼ

blood coagulation factor IIIcoagulation factor IIIfactor IIIthromboplastintissue factor

WordNet   license wordnet

「coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors」
factor X

TF」

  [★]


coagulation factor III」

  [★]

凝固第III因子

blood coagulation factor IIIfactor IIIprothrombinasethromboplastintissue factor


tissue factor pathway inhibitor」

  [★] 組織因子経路インヒビター TFPI

TFPI


factor」

  [★]

  • n.
elementelementaryfactorialparameter

WordNet   license wordnet

「be a contributing factor; "make things factor into a company''s profitability"」

WordNet   license wordnet

「any of the numbers (or symbols) that form a product when multiplied together」

WordNet   license wordnet

「an independent variable in statistics」

WordNet   license wordnet

「anything that contributes causally to a result; "a number of factors determined the outcome"」

PrepTutorEJDIC   license prepejdic

「(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize」

WordNet   license wordnet

「consider as relevant when making a decision; "You must factor in the recent developments"」
factor in, factor out

WordNet   license wordnet

「resolve into factors; "a quantum computer can factor the number 15"」
factor in, factor out

fact」

  [★]

  • n.
actualactuallyin factin practiceindeedpractically

WordNet   license wordnet

「an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"」

WordNet   license wordnet

「a concept whose truth can be proved; "scientific hypotheses are not facts"」

WordNet   license wordnet

「a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"」

WordNet   license wordnet

「a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"」

PrepTutorEJDIC   license prepejdic

「〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行」

tissue」

  [★]

  • n.

WordNet   license wordnet

「a soft thin (usually translucent) paper」
tissue paper

WordNet   license wordnet

「part of an organism consisting of an aggregate of cells having a similar structure and function」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper」




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