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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/26 07:29:35」(JST)

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Tinidazole is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of amoebic and parasitic infections. It was developed in 1972. A derivative of 2-methylimidazole, it is a prominent member of the nitroimidazole antibiotics.^[1]

Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex.

Uses

A large body of clinical data exists to support use of tinidazole for infections from amoebae, giardia, and trichomonas, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole tolerance. Tinidazole may also be used to treat a variety of other bacterial infections (e.g., as part of combination therapy for Helicobacter pylori eradication protocols).^[2]

Side effects

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.

Half-life

Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.

References

^ Ebel, K., Koehler, H., Gamer, A. O., & Jäckh, R. “Imidazole and Derivatives.” In Ullmann’s Encyclopedia of Industrial Chemistry; 2002 Wiley-VCH, doi:10.1002/14356007.a13_661
^ Edwards, David I. "Nitroimidazole drugs - action and resistance mechanisms. I. Mechanism of action" Journal of Antimicrobial Chemotherapy 1993, volume 31, pp. 9-20. doi:10.1093/jac/31.1.9.

External links

MedlinePlus Drug Information: Tinidazole
Drug Bank Facts on Tinidazole

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 細菌性膣炎 bacterial vaginosis
2. ジアルジア症の治療および予防 treatment and prevention of giardiasis
3. 抗原虫治療 antiprotozoal therapies
4. トリコモナス trichomoniasis
5. 赤痢アメーバによる腸菅アメーバ症 intestinal entamoeba histolytica amebiasis

English Journal

HPTLC method for Simultaneous Determination of Norfloxacin and Tinidazole in presence of Tinidazole Impurity.

Naguib IA1, Abdelaleem EA1, Hassan ES1, Ali NW1.
Journal of chromatographic science.J Chromatogr Sci.2019 Jan 1;57(1):81-86. doi: 10.1093/chromsci/bmy085.
PMID 30395212

Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy.

Henien M1, Nyirjesy P, Smith K.
Sexually transmitted diseases.Sex Transm Dis.2019 Jan;46(1):e1-e2. doi: 10.1097/OLQ.0000000000000903.
PMID 30106840

A triazine-based conjugated microporous polymer composite for magnetic solid phase extraction of 5-nitroimidazoles coupled with UPLC-MS/MS for quantification.

Yang W 1, Wu X , Liu T , Wang T , Hou X .
The Analyst.Analyst.2018 Nov 19;143(23):5744-5753. doi: 10.1039/c8an01600c.
PMID 30325370

Japanese Journal

メトロニダゾールに対する副反応のためにチニダゾールで治療し得た後天性免疫不全症候群に併発したアメーバ性大腸炎の1例

自治医科大学紀要 33, 147-153, 2011-03-01
NAID 110008507492

Stability Indicating Methods for the Determination of Norfloxacin in Mixture with Tinidazole

Chemical & pharmaceutical bulletin 55(1), 1-6, 2007-01-01
NAID 110006151423

Voltammetric Determination of Tinidazole Using a Glassy Carbon Electrode Modified with Single-Wall Carbon Nanotubes

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20(5), 821-824, 2004-05-10
NAID 10012941757

Related Pictures

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「チニダゾール」

Tinidazole
Clinical data
Trade names	Fasigyn, Simplotan, Tindamax
AHFS/Drugs.com	Monograph
MedlinePlus	a604036
Pregnancy; category	AU: B3; US: C (Risk not ruled out); ;
Routes of; administration	Oral
ATC code	J01XD02 (WHO) P01AB02 (WHO) QP51AA02 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	12%
Metabolism	Hepatic (CYP3A4)
Biological half-life	12–14 hours
Excretion	Urine (20–25%), faeces (12%)
Identifiers
	IUPAC name 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole;
CAS Number	19387-91-8 ;
PubChem CID	5479;
DrugBank	DB00911 ;
ChemSpider	5279 ;
UNII	033KF7V46H;
KEGG	D01426 ;
ChEMBL	CHEMBL1220 ;
NIAID ChemDB	007940;
ECHA InfoCard	100.039.089
Chemical and physical data
Formula	C8H13N3O4S
Molar mass	247.273 g/mol
3D model (Jmol)	Interactive image;
	SMILES [O-][N+](=O)c1cnc(n1CCS(=O)(=O)CC)C ;
	InChI InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3 ; Key:HJLSLZFTEKNLFI-UHFFFAOYSA-N ;
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英: tinidazole
商: ハイシジン, Tindamax

[Ebel-1] Ebel, K., Koehler, H., Gamer, A. O., & Jäckh, R. “Imidazole and Derivatives.” In Ullmann’s Encyclopedia of Industrial Chemistry; 2002 Wiley-VCH, doi:10.1002/14356007.a13_661

[2] Edwards, David I. "Nitroimidazole drugs - action and resistance mechanisms. I. Mechanism of action" Journal of Antimicrobial Chemotherapy 1993, volume 31, pp. 9-20. doi:10.1093/jac/31.1.9.

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tinidazole