tigan

同

trimethobenzamide

WordNet

1. (law) a party to a lawsuit; someone involved in litigation; "plaintiffs and defendants are both litigants" (同)litigator
2. British playwright (1911-1977) (同)Terence Rattigan, Sir Terence Mervyn Rattigan

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1. 訴訟当事者

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/18 08:23:59」(JST)

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Trimethobenzamide

Systematic (IUPAC) name
N-{[4-(2-dimethylaminoethoxy)phenyl]methyl}- 3,4,5-trimethoxy-benzamide
Clinical data
Trade names	Tigan
AHFS/Drugs.com	monograph
MedlinePlus	a682693
Pregnancy cat.	US: C
Legal status	US: ℞-only
Routes	Oral, rectal, intramuscular
Pharmacokinetic data
Bioavailability	60-100%
Half-life	7 to 9 hours (mean)
Excretion	urine (30-50%), faeces
Identifiers
CAS number	138-56-7 Y
ATC code	None
PubChem	CID 5577
DrugBank	DB00662
ChemSpider	5375 Y
UNII	W2X096QY97 Y
ChEBI	CHEBI:27796 Y
ChEMBL	CHEMBL1201256 N
Chemical data
Formula	C21H28N2O5
Mol. mass	388.458 g/mol
SMILES O=C(c1cc(OC)c(OC)c(OC)c1)NCc2ccc(OCCN(C)C)cc2
InChI InChI=1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24) Y Key:FEZBIKUBAYAZIU-UHFFFAOYSA-N Y
N (what is this?)  (verify)

Trimethobenzamide (Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. It is often prescribed for patients with gastroenteritis, medication-induced nausea, and other illnesses. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects. In the United States, it requires a prescription.

Mechanism of action

Although the specific mechanism through which trimethobenzamide functions is unknown, it is believed to affect the chemoreceptor trigger zone (CTZ) of the medulla oblongata.

Side effects

Possible side effects include drowsiness, dizziness, headache, diarrhea, muscle cramps, and blurred vision. More serious adverse effects include skin rash, tremors, parkinsonism, and jaundice.

Formulations

Trimethobenzamide is marketed under the brand names Tebamide and Tigan, manufactured by GlaxoSmithKline and King Pharmaceuticals, respectively. It is available as oral capsules and injectable formulations.

Trimethobenzamide was also available as a rectal suppository, but such formulations were banned by the U.S. Food and Drug Administration on April 6, 2007 due to unproven efficacy.

See also

• Benzamide

References

External links

• Tebamide (manufacturer's website)
• Tigan (manufacturer's website)

UpToDate Contents

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• 1. 制吐剤の特性 characteristics of antiemetic drugs
• 2. パーキンソン病の薬理学的治療 pharmacologic treatment of parkinson disease
• 3. 経口補水療法 oral rehydration therapy
• 4. パーキンソン病における症状の変動およびジスキネジア motor fluctuations and dyskinesia in parkinson disease

English Journal

• Balloon protection of the Labbé vein during transarterial embolization of a dural arterio-venous fistula.

• Pop R1, Manisor M2, Wolff V3, Aloraini Z2, Tigan L4, Kehrli P4, Marescaux C3, Beaujeux R2.
• Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.Interv Neuroradiol.2015 Dec;21(6):728-32. doi: 10.1177/1591019915609119. Epub 2015 Oct 5.
• INTRODUCTION: Endovascular treatment of type III dural arterio-venous fistulas can be challenging if the fistulous point is close to a functionally important cortical vein.METHODS: A technique is described for temporary balloon protection of the vein of Labbé during transarterial Onyx embolization
• PMID 26438051

• CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation.

• Tigan AS1, Bellutti F1, Kollmann K1,2, Tebb G3, Sexl V1.
• Oncogene.Oncogene.2015 Oct 26. doi: 10.1038/onc.2015.407. [Epub ahead of print]
• The G1 cell-cycle kinase CDK6 has long been thought of as a redundant homolog of CDK4. Although the two kinases have very similar roles in cell-cycle progression, it has recently become apparent that they differ in tissue-specific functions and contribute differently to tumor development. CDK6 is di
• PMID 26500059

• Canadian Headache Society systematic review and recommendations on the treatment of migraine pain in emergency settings.

• Orr SL1, Aubé M2, Becker WJ3, Davenport WJ4, Dilli E5, Dodick D6, Giammarco R7, Gladstone J8, Leroux E9, Pim H9, Dickinson G10, Christie SN10.
• Cephalalgia : an international journal of headache.Cephalalgia.2015 Mar;35(3):271-84. doi: 10.1177/0333102414535997. Epub 2014 May 29.
• BACKGROUND: There is a considerable amount of practice variation in managing migraines in emergency settings, and evidence-based therapies are often not used first line.METHODS: A peer-reviewed search of databases (MEDLINE, Embase, CENTRAL) was carried out to identify randomized and quasi-randomized
• PMID 24875925

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