ticarcillin

出典: meddic

チカルシリン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/15 22:08:42」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • High level of resistance to Aztreonam and Ticarcillin in Pseudomonas aeruginosa isolated from soil of different crops in Brazil.
  • Pitondo-Silva A1, Martins VV1, Fernandes AF1, Stehling EG2.Author information 1Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brazil.2Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brazil. Electronic address: elianags@usp.br.AbstractPseudomonas aeruginosa can be found in water, soil, plants and, human and animal fecal samples. It is an important nosocomial pathogenic agent characterized by an intrinsic resistance to multiple antimicrobial agents and the ability to develop high-level (acquired) multidrug resistance through some mechanisms, among them, by the acquisition of plasmids and integrons, which are mobile genetic elements. In this study, 40 isolates from Brazilian soil were analyzed for antibiotic resistance, presence of integrons and plasmidial profile. The results demonstrated that the vast majority of the isolates have shown resistance for aztreonam (92.5%, n=37) and ticarcillin (85%, n=34), four isolates presented plasmids and eight isolates possess the class 1 integron. These results demonstrated that environmental isolates of P. aeruginosa possess surprising antibiotic resistance profile to aztreonam and ticarcillin, two antimicrobial agents for clinical treatment of cystic fibrosis patients and other infections occurred by P. aeruginosa.
  • The Science of the total environment.Sci Total Environ.2013 Dec 22;473-474C:155-158. doi: 10.1016/j.scitotenv.2013.12.021. [Epub ahead of print]
  • Pseudomonas aeruginosa can be found in water, soil, plants and, human and animal fecal samples. It is an important nosocomial pathogenic agent characterized by an intrinsic resistance to multiple antimicrobial agents and the ability to develop high-level (acquired) multidrug resistance through some
  • PMID 24369293
  • Stability and compatibility of antimicrobial lock solutions.
  • Bookstaver PB, Rokas KE, Norris LB, Edwards JM, Sherertz RJ.Author information P. Brandon Bookstaver, Pharm. D., BCPS (AQ-ID), AAHIVP, is Associate Professor and Vice Chair, Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy (SCCP), University of South Carolina Campus, Columbia. Kristina E. E. Rokas, Pharm.D., is Postgraduate Year 2 Infectious Diseases Resident, Department of Pharmacy, Wake Forest Baptist Health, Winston-Salem, NC. LeAnn B. Norris, Pharm.D., BCPS, BCOP, is Assistant Professor, Department of Pharmacy Practice and Outcomes Sciences; and Julie M. Edwards is a Pharm.D. candidate, SCCP, University of South Carolina Campus. Robert J. Sherertz, M.D., is Professor Emeritus, School of Medicine, Wake Forest University, Winston-Salem.AbstractPURPOSE: Published stability and compatibility data on a growing array of solutions used for antimicrobial lock therapy (ALT) are reviewed.
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.Am J Health Syst Pharm.2013 Dec 15;70(24):2185-98. doi: 10.2146/ajhp120119.
  • PURPOSE: Published stability and compatibility data on a growing array of solutions used for antimicrobial lock therapy (ALT) are reviewed.SUMMARY: ALT involves the instillation of a highly concentrated antimicrobial, often in combination with an anticoagulant, into a central venous catheter (CVC) l
  • PMID 24296841
  • Is Chryseobacterium indologenes a shunt-lover bacterium? A case report and review of the literature.
  • Ozcan N, Dal T, Tekin A, Kelekci S, Can S, Ezin O, Kandemir I, Gul K.Author information Dicle University Medical Faculty, Department of Medical Microbiology; Dicle University Medical Faculty, Department of Pediatrics, Diyarbak?r, Turkey.AbstractChryseobacterium indologenes is a non-fermentative Gram-negative bacillus formerly belonging to the Flavobacterium genus. It is widely found in water and soil, also on wet surfaces of the hospital environment. It rarely causes infections and is usually associated with altered immune status or indwelling devices. We present a case of ventriculoperitoneal shunt infection caused by C. indologenes in a premature pediatric patient. A six-month-old male infant with congenital hydrocephalus and ventriculoperitoneal shunt was admitted with complaints of irritability, high fever and projectile vomiting. He was diagnosed as suffering from meningitis based on the clinical symptoms and laboratory findings of cerebrospinal fluid. The ventriculoperitoneal shunt was externalized and cerebrospinal fluid samples were sent for bacterial cultures. The isolated bacterium was identified as C. indologenes by conventional methods and the BD Phoenix 100 (Becton Dickinson, MD, USA) fully automated microbiology system. Antimicrobial susceptibility testing was performed by the microdilution method and Kirby-Bauer's disk diffusion method according to the Clinical and Laboratory Standards Institute guidelines. The isolate was found susceptible to ciprofloxacin, levofloxacin, cefoperazone and trimethoprim-sulfamethoxazole, while it was resistant to amikacin, aztreonam, cefepime, ceftazidime, gentamicin, imipenem and ticarcillin-clavulanic acid. The treatment was started with trimethoprim-sulfamethoxazole and cefoperazone-sulbactam The ventriculoperitoneal shunt was then removed. The patient was fully healed after two weeks and discharged. Central nervous system infection is a rare form of C. indologenes infections. The case presented herein may make a useful contribution to the existing literature.
  • Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive.Infez Med.2013 Dec 1;21(4):312-6.
  • Chryseobacterium indologenes is a non-fermentative Gram-negative bacillus formerly belonging to the Flavobacterium genus. It is widely found in water and soil, also on wet surfaces of the hospital environment. It rarely causes infections and is usually associated with altered immune status or indwel
  • PMID 24335463

和文文献

  • Antibiotic Resistance and Extended-Spectrum β-Lactamases in Isolated Bacteria from Seawater of Algiers Beaches (Algeria)
  • ALOUACHE SOUHILA,KADA MOHAMED,MESSAI YAMINA [他],ESTEPA VANESA,TORRES CARMEN,BAKOUR RABAH
  • Microbes and environments 27(1), 80-86, 2012-03-01
  • … The most significant resistance rates were observed for amoxicillin and ticarcillin, whereas they were relatively low for ceftazidime, cefotaxime and imipenem. … ticarcillin, 19.6% and 47.7%), and for 2 sites relatively preserved from anthropogenic influence, resistance rates were lowest (amoxicillin, 1.5% and 16%; … ticarcillin, 0.8% and 2.6%). …
  • NAID 10030122942
  • Aeromonas hydrophila subsp. dhakensis Isolated from Feces, Water and Fish in Mediterranean Spain
  • Esteve Consuelo,Alcaide Elena,Blasco María Dolores
  • Microbes and Environments 27(4), 367-373, 2012
  • … They were all resistant to ticarcillin, amoxicillin-clavuranic acid, cefoxitin, and imipenem, regardless of its source. …
  • NAID 130001877548
  • In vitro flowering and viable seed setting of transgenic lettuce cultures
  • Franklin G.,Oliveira A. L.,Dias [他]
  • Plant biotechnology 28(1), 63-68, 2011-03-25
  • … Transgenic calluses and shoot buds were induced on MS medium augmented with 0.1 mg l-1 benzyladenine (BA), 0.1 mg l-1 α-naphtaleneacetic acid (NAA), 100 mg l-1 kanamycin and 500 mg l-1 timentin (ticarcillin clavulanate). …
  • NAID 10028258605

関連リンク

関連画像


押しても画像が表示されない場合はサーバが混雑しています。2週間ほどあけて、再度押下してください。


★リンクテーブル★
リンク元抗菌薬」「チカルシリン
拡張検索ticarcillin sodium/potassium clavulanate mixture」「ticarcillin sodium

抗菌薬」

  [★]

antibacterial drug, antibacterial
抗生剤薬理学抗菌薬一覧抗細菌薬
first aid step 1 2006 p.165

定義

  • 細菌/微生物に静菌作用、殺菌作用を示す物質。結果として、人において病原性を除去する目的で使用される。
  • このうち、微生物によって産生される物質を抗生物質と呼ぶ


作用機序による分類

first aid step 1 2006 p.165
  Mechanism of action Drugs
1 Block cell wall synthesis by inhibition of peptidoglycan cross-linking penicillin, ampicillin, ticarcillin, piperacillin, imipenem, aztreonam, cephalosporins
2 Block peptidoglycan synthesis bacitracin, vancomycin, cycloserine
3 Disrupt bacterial/fungal cell membranes polymyxins
4 Disrupt fungal cell membranes amphotericin B, nystatin, fluconazole/azoles
5 Block nucleotide synthesis sulfonamides, trimethoprim
6 Block DNA topoisomerases quinolones
7 Block mRNA synthesis rifampin
8 Block protein synthesis at 50S ribosomal subunit chloramphenicol, erythromycin/macrolides, lincomycin, clindamycin, streptogramins (quinupristin, dalfopristin), linezolid
9 Block protein synthesis at 30S ribosomal subunit aminoglycosides, tetracyclines, spectinomycin
 ATuSi → あつし


薬物動態

  • 濃度依存性:アミノグリコシド系抗菌薬、ニューロキノロン系抗菌薬
  • 時間依存性:βラクタム系抗菌薬

治療期間

小児

尾内一信 ; 第 39 回日本小児感染症学会教育講演 2 小児感染症の抗菌薬療法 -耐性菌時代の適正使用-
感染臓器・臨床診断 原因菌 投与期間(抗菌薬)
髄膜炎 インフルエンザ菌 7-10日
肺炎球菌 10-14日
髄膜炎菌 7-10日
GBS,腸内細菌,リステリア 21日
中耳炎 <2 歳 10日
2 歳≦ 5-7日
咽頭炎 A 群連鎖球菌 10日(ペニシリン系薬)
5日(セフェム系薬)
肺炎 肺炎球菌,インフルエンザ菌 解熱後3-4日
黄色ブドウ球菌 3-4週間
マイコプラズマ,クラミジア 10-21日
腎臓、膀胱炎、腎盂腎炎 大腸菌,プロテウス,腸球菌 3日
14日
骨髄炎 黄色ブドウ球菌 21日
連鎖球菌,インフルエンザ菌 14日

主要な感染症の抗菌薬投与期間

感染レジマニュ p.27
骨髄炎 4-6週
耳鼻咽喉 中耳炎 5-7日
副鼻腔炎 5-14日
A群溶連菌咽頭炎 10日
肺炎 肺炎球菌 7-10日 or 解熱後3日間
インフルエンザ菌 10-14日
マイコプラズマ 14日(7-10日)
レジオネラ 21日
肺化膿症 28-42日
心臓 感染性心内膜炎 α連鎖球菌 2-4週
黄色ブドウ球菌 4-6週
消化管 腸炎 赤痢菌 3日
チフス 14日(5-7日)
パラチフス
腹膜炎 特発性 5日
二次性 10-14日
胆肝膵 肝膿瘍 細菌性 4-8週
アメーバ性 10日
尿路 膀胱炎 3日
急性腎盂腎炎 14日(7-10日)
急性腎盂腎炎・再発 6週
慢性前立腺炎 1-3ヶ月
髄腔 髄膜炎 インフルエンザ菌 7-10日
髄膜炎菌
肺炎球菌 10-14日
リステリア 21日
敗血症 敗血症 コアグラーゼ陰性ブドウ球菌 5-7日
黄色ブドウ球菌 28日(14日)
グラム陰性桿菌 14日(7-14日)
カンジダ 血液培養陰性化後, 14日

ソース不明

妊婦に避けるべき抗菌薬

  • Antibiotics to avoid in pregnancy
  • Sulfonamides––kernicterus.
  • Aminoglycosides––ototoxicity.
  • Fluoroquinolones––cartilage damage.
  • Erythromycin––acute cholestatic hepatitis in mom
(and clarithromycin––embryotoxic).
  • Metronidazole––mutagenesis.
  • Tetracyclines––discolored teeth, inhibition of bone growth.
  • Ribavirin (antiviral)––teratogenic.
  • Griseofulvin (antifungal)––teratogenic.
  • Chloramphenicol––“gray baby.”
  • SAFE Moms Take Really Good Care.

使っても良い

YN.H-24
  • βラクタム系
  • エリスロマイシン、アジスロマイシン

参考

  • 抗菌薬インターネットブック
まとまっていてよい
[display]http://www.antibiotic-books.jp

抗菌薬一覧

チカルシリン」

  [★]

ticarcillin, TIPC
ticarcillinum
Ticar
チカルシリンナトリウム ticarcillin sodium



ticarcillin sodium/potassium clavulanate mixture」

  [★] チカルシリンナトリウム・クラブラン酸カリウム合剤


ticarcillin sodium」

  [★]

ticarcillin




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡