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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/19 23:33:25」(JST)
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English Journal
- A rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells.
- Janssen JS, Sharma V, Pugazhenthi U, Sladek C, Wood WM, Haugen BR.SourceDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2011 Jun 6;339(1-2):1-6. Epub 2011 Mar 31.
- Retinoid X receptor (RXR) signaling influences thyrotrope function. Synthetic RXR agonists, rexinoids, can cause central hypothyroidism. To test the hypothesis that endogenous rexinoids contribute to the TSH 'set point', TαT1 mouse thyrotrope cells were treated with a rexinoid antagonist, LG101208.
- PMID 21458528
- Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.
- Martines EV, Reggiani PC, Schwerdt JI, Goya RG, Console GM.SourceDepartment of Cytology, Histology and Embryology B, University of La Plata (UNLP), La Plata, Argentina.
- Cells, tissues, organs.Cells Tissues Organs.2011;194(1):67-75. Epub 2011 Jan 7.
- There is evidence of the existence of a bidirectional relationship between the thymus gland and the thyroid axis. Since the thymic peptide thymulin possesses hypophysiotropic activity, we undertook the task of assessing the histomorphometric changes induced by thymulin deficiency on the thyrotrope p
- PMID 21212643
Japanese Journal
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
- Kobayashi Kenichi,Yamamoto Kazutoshi,Kikuyama Sakae,Machida Takeo,Kobayashi Tetsuya
- Journal of Toxicologic Pathology 22(3), 187-194, 2009
- Congenitally primary hypothyroid growth-retarded (grt) mice exhibit a characteristic growth pause followed by delayed onset of pubertal growth. We characterized the developmental pattern of somatotrop …
- NAID 130000137720
- POSSIBLE EXISTENCE OF THYROTROPE-STIMULARING FACTOR IN THE BULLFROG HYPOTHALAMUS
- OKADA Reiko,YAMAMOTO Kazutoshi,KIKUYAMA Sakae
- Proceedings of the Japan Society for Comparative Endocrinology 16, 74, 2001-12-01
- NAID 10008731524
Related Links
- Surface ectoderm · Integumentary system · Trichocyte ・ Keratinocyte · Nervous system · anterior pituitary (Gonadotrope, Corticotrope, Thyrotrope, Somatotrope, Lactotroph ). Neural crest · Endocrine system · Chromaffin cell ・ Parafollicular cell ...
Related Pictures
★リンクテーブル★
| リンク元 | 「下垂体前葉ホルモン」 |
「下垂体前葉ホルモン」
分泌されるホルモン
- 単純ペプチドホルモン
- 糖タンパク質ホルモン
GOO. chapter 55
| 名称 | 構造 | 分泌細胞 | 下垂体前葉細胞 全細胞に対する 産生細胞の割合 |
染色性 | サブユニット | 残基数 (aa.) |
分子量 (kDa) |
その他 | ||
| 成長ホルモン | GH | ペプチド | somatotroph | 40-50% | 好酸性 | 1 | 191 | 22 | ||
| プロラクチン | PRL | mammotroph | 10-25% | 好酸性 | 1 | 199 | 23 | |||
| 副腎皮質刺激ホルモン | ACTH | corticotroph | 0.1 | 好塩基性 | 嫌色素性 | 1 | 39 | 4.5 | POMC由来 | |
| 甲状腺刺激ホルモン | TSH | 糖タンパク | thyrotroph | 0.05 | 好塩基性 | 2 | α: 92, β:118 | 28 | αサブユニットは共通 | |
| 卵胞刺激ホルモン | FSH | gonadotroph | 10-15% | 好塩基性 | 2 | α: 92, β:111 | 32.6 | |||
| 黄体形成ホルモン | LH | 好塩基性 | 2 | α: 92, β:121 | 29.4 | |||||
HIM.2196
| Table 333-1 Anterior Pituitary Hormone Expression and Regulation | |||||
| Cell | corticotrope | somatotrope | lactotrope | thyrotrope | gonadotrope |
| Tissue-specific transcription factor | T-Pit | Prop-1, Pit-1 | Prop-1, Pit-1 | Prop-1, Pit-1, TEF | SF-1, DAX-1 |
| Fetal appearance | 6 weeks | 8 weeks | 12 weeks | 12 weeks | 12 weeks |
| Hormone | POMC | GH | PRL | TSH | FSH LH |
| Chromosomal locus | 2p | 17q | 6 | －6q; －1p | －11p; －19q |
| Protein | ポリペプチド | 糖タンパク | |||
| Amino acids | 266 (ACTH 1–39) | 191 | 199 | 211 | 210 204 |
| Stimulators | CRH, AVP, gp-130 cytokines | GHRH, ghrelin, bromocriptine(1) | estrogen, TRH, VIP | TRH | GnRH, activins, estrogen |
| Inhibitors | glucocorticoids | somatostatin, IGF-I | dopamine | T3, T4, dopamine, somatostatin, glucocorticoids | sex steroids, inhibin |
| Target gland | adrenal | liver, other tissues | breast, other tissues | thyroid | ovary, testis |
| Trophic effect | steroid production | IGF-I production, growth induction, insulin antagonism | milk production | T4 synthesis and secretion | sex steroid production, follicle growth, germ cell maturation |
- (1):QB.D-253