甲状腺腫大
- 関
- enlarged thyroid
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English Journal
- Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2Rγ(null) mouse.
- Fujii E1, Kato A2, Chen YJ3, Matsubara K3, Ohnishi Y4, Suzuki M2.Author information 1Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan. Electronic address: fujiietk@chugai-pharm.co.jp.2Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.3PharmaLogicals Research, Pte. Ltd., 11 Biopolis Way, #05-08/09 Helios, Singapore 138667, Singapore.4Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.AbstractThere is a growing need for modeling the human thyroid to link data obtained from animals to humans because of its sensitivity to radiation exposure and endocrine disruption chemicals. In a scid mouse model produced by transplanting human thyroid tissues, leakiness and thymic lymphoma that occurs spontaneously in the scid mouse can complicate the interpretation of experimental results. Considering that the NOD.Cg-Prkdc(scid)Il2rg(tm1Sug)/Jic mouse (NOD/Shi-scid, IL-2Rγ(null) or NOG mouse) may be a better host because this strain has low incidence of leakiness and thymic lymphoma, we have evaluated the potential of a model that allows long-term observation of non-tumor human thyroid tissues in this mouse. We transplanted tissues of human adenomatous goiter into NOG mice and examined the tissues histopathologically. The morphology of human adenomatous goiter tissues was maintained from 24 to 44 weeks after transplantation in NOG mice with no noted differences between donor-matched tissues or the weeks after transplantation. The tissues expressed thyroglobulin protein and mRNA as well as thyroperoxidase. Endothelial cells originating from human were found in the transplanted tissues and were thought to be a characteristic of this model. The intactness of the tissues before transplantation was found to affect the rate of tissue engraftment. From the present results we have concluded that transplanted thyroid tissues in NOG mice maintain the histopathological characteristics of their origin for long terms. Therefore this model was thought feasible for toxicity evaluation.
- Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2014 Jul;66(4):203-9. doi: 10.1016/j.etp.2014.01.006. Epub 2014 Feb 28.
- There is a growing need for modeling the human thyroid to link data obtained from animals to humans because of its sensitivity to radiation exposure and endocrine disruption chemicals. In a scid mouse model produced by transplanting human thyroid tissues, leakiness and thymic lymphoma that occurs sp
- PMID 24589354
- Thyroid Disorders and the Prevalence of Antithyroid Antibodies in Shiraz Population.
- Karimi F1, Kalantarhormozi MR2, Dabbaghmanesh MH3, Ranjbar Omrani G3.Author information 1Endocrine Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. hormone@sums.ac.ir.2Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.3Endocrine Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.AbstractBACKGROUND AND OBJECTIVES: Thyroid dysfunction is a common health problem affecting millions of patients worldwide. Autoimmune thyroid disorders are among the most common autoimmune disorders. In this population-based study, we assessed the prevalence of abnormal thyroid function, antithyroid antibodies and the probable relationship between them in Shiraz, southern Iran.
- Archives of Iranian medicine.Arch Iran Med.2014 May;17(5):347-351.
- BACKGROUND AND OBJECTIVES: Thyroid dysfunction is a common health problem affecting millions of patients worldwide. Autoimmune thyroid disorders are among the most common autoimmune disorders. In this population-based study, we assessed the prevalence of abnormal thyroid function, antithyroid antibo
- PMID 24784864
- Resection of huge retrosternal goiter through a novel combined cervical and robot-assisted approach.
- Wang S1, Xu S, Liu B.Author information 1Department of Thoracic Surgery, Northern Hospital, Shenyang, Liaoning, China.AbstractA 53-year-old man was referred to our department with a history of cough, especially at night, for 3 months. He was found to have a huge retrosternal goiter. We applied a novel combined cervical and robot-assisted approach to resect this difficult goiter. Using the da Vinci robot system, the intrathoracic part of the goiter was dissected and mobilized completely from the mediastinum to the inlet of the thorax. The dissected part of the goiter was left in the thorax. A right cervical half-collar incision about 6 cm was then performed. The goiter was finally removed from the neck incision. Histopathologic examination reported a multinodular goiter. By the method shown in the case, resection of huge retrosternal goiters through a combined cervical and robot-assisted approach is feasible and safe. This method provides an alternative option to the more invasive traditional approaches.
- Artificial organs.Artif Organs.2014 May;38(5):431-3. doi: 10.1111/aor.12196. Epub 2013 Oct 3.
- A 53-year-old man was referred to our department with a history of cough, especially at night, for 3 months. He was found to have a huge retrosternal goiter. We applied a novel combined cervical and robot-assisted approach to resect this difficult goiter. Using the da Vinci robot system, the intrath
- PMID 24117750
Japanese Journal
- 甲状腺腫 (画像診断update--検査の組み立てから診断まで) -- (気になる症状・所見に対する画像検査の進め方 中枢神経・頭頸部)
- グルココルチコイド甲状腺内局所注射による甲状腺疾患の治療
- 永田 格 [他],青木 矩彦,脇坂 行一
- 日本内分泌学会雑誌 50(4), 774-787,750, 1974
- 慢性甲状腺炎, バセドウ病或いは亜急性甲状腺炎における甲状腺腫内に, Triamcinolone-acetonideの如きグルココルチコイドを反覆注射する治療法に関して報告する.注射は簡単であり, 月1～2回 (40～80mg) の投与で, その甲状腺腫が著しく縮小して維持された.局所の圧迫または炎症による諸症状, そして全身の急性炎症性所見も同時に改善された.治療休止 …
- NAID 130001938734
- 竹下 吉樹 [他],依田 純三,服部 宏,上田 淑行,福山 一郎,阿部 秀康,吉田 俊秀,中埜 幸治,若林 保良,吉田 秀雄
- 日本内分泌学会雑誌 50(10), 1367-1372, 1974
- … <BR>In this patient, moist skin, extremely high blood and urinary sugar and no heat intolerance were suspected of diabetic coma, but hypertension, tachycardia, thyromegaly and delirium were suspected of thyroid crisis. …
- NAID 130001938708
Related Links
- Define thyromegaly: enlargement of the thyroid gland, causing a swelling in the front part of the neck; called also struma. adj., adj goit´rous. If there is evidence of... thyromegaly - definition of thyromegaly by Medical dictionary ...
- Thyromegaly definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Thesaurus Translate Puzzles & Games Word of the Day Blog Slideshows Apps by Dictionary Log Out ...
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- 英
- thyromegaly, enlarged thyroid