thyroglobulin

出典: meddic

サイログロブリン

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「an iodine containing protein that is obtained from the thyroid gland and exhibits the general properties of the globulins」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/21 06:15:40」(JST)

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英文文献

  • Bipolar disorder and antithyroid antibodies: review and case series.
  • Bocchetta A1, Traccis F2, Mosca E3, Serra A4, Tamburini G5, Loviselli A6.
  • International journal of bipolar disorders.Int J Bipolar Disord.2016 Dec;4(1):5. doi: 10.1186/s40345-016-0046-4. Epub 2016 Feb 11.
  • Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to play a role in specific forms of mood disorders. Potentially related forms include treatment-
  • PMID 26869176
  • Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line.
  • Mascia A1, Gentile F1, Izzo A2, Mollo N2, De Luca M3, Bucci C3, Nitsch L2, Calì G1.
  • Journal of cellular physiology.J Cell Physiol.2016 Aug;231(8):1695-708. doi: 10.1002/jcp.25267. Epub 2015 Dec 10.
  • Rab7 regulates the biogenesis of late endosomes, lysosomes, and autophagosomes. It has been proposed that a functional and physical interaction exists between Rab7 and Rac1 GTPases in CDH1 endocytosis and ruffled border formation. In FRT cells over-expressing Rab7, increased expression and activity
  • PMID 26599499
  • Does the presence of autoantibodies without autoimmune diseases and hereditary thrombophilia have an effect on recurrent pregnancy loss?
  • Mumusoglu S1, Beksac MS1, Ekiz A2, Ozdemir P3, Hascelik G4.
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Jul;29(14):2352-7. doi: 10.3109/14767058.2015.1085964. Epub 2015 Sep 18.
  • OBJECTIVE: To assess whether the presence of autoantibodies has any effect on recurrent pregnancy loss (RPL) and obstetric complications in women who do not have autoimmune diseases and hereditary thrombophilia.METHODS: Retrospectively, 515 patients who underwent antibody investigation with anti-nuc
  • PMID 26381475

和文文献

  • Three Cases of Struma Ovarii Underwent Laparoscopic Surgery with Definite Preoperative Diagnosis
  • Binti Md Nor Nurliza,Kusumoto Tomoyuki,Inoue Seiji,Nakamura Keiichiro,Seki Noriko,Hongo Atsushi,Kodama Junichi,Hiramatsu Yuji
  • Acta Medica Okayama 67(3), 191-195, 2013-06-00
  • … Laboratory examination revealed elevated serum thyroglobulin, which led to the diagnosis of struma ovarii. …
  • NAID 120005295918
  • 8. 甲状腺癌(<特集>癌のリンパ節微小転移-外科治療からみた臨床意義-)
  • 亀山 香織,高見 博
  • 日本外科学会雑誌 114(1), 34-37, 2013-01-01
  • NAID 110009578671
  • Some fine-structural findings on the thyroid gland in Apc^<1638T/1638T> mice that express a C-terminus lacking truncated Apc
  • YOKOYAMA Atsushi,NOMURA Ryuji,KUROSUMI Masafumi,SHIMOMURA Atsushi,ONOUCHI Takanori,IIZUKA KOGO Akiko,SMITS Ron,FODDE Riccardo,ITOH Mitsuyasu,SENDA Takao
  • Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology 45(3), 161-167, 2012-09-01
  • NAID 10031073930

関連リンク

The thyroglobulin test is primarily used as a tumor marker to evaluate the effectiveness of treatment for thyroid cancer and to monitor for recurrence. Thyroglobulin testing is also occasionally ordered to help determine the cause of ...
stained with Anti-Thyroglobulin. Clinical application for IR509/IS509 For classification of tumors of thyroid origin such as thyroid follicular carcinoma ... The neoplastic cells show a strong cytoplasmic staining reaction. Clinical ...

関連画像

Effects of amiodarone therapy on thyroid  › Medications › ThyroglobulinThyroglobulin proteinHormones of Thyroid Gland | howMed > Gallery For > Thyroglobulin Structure attached to the thyroglobulin molecule


★リンクテーブル★
リンク元サイログロブリン」「Tg」「TG
拡張検索antithyroglobulin antibody

サイログロブリン」

  [★]

thyroglobulin TG Tg
チログロブリンチレオグロブリン thyreoglobulin
甲状腺甲状腺ホルモン抗サイログロブリン抗体

概念

  • 糖タンパク質、330 kDa、二量体
  • 濾胞上皮細胞で合成され、主に甲状腺濾胞腔に存在。
  • 甲状腺ホルモン合成の足場
  • サイログロブリン中のチロシン残基のヨード化と縮合により合成される → 甲状腺ホルモン(T3やT4)

解釈

高値

  • 甲状腺腫瘍
  • 腫瘍マーカーとなる
  • 良性・悪性の区別はできない
腫瘍が甲状腺にあるとき高値。良性の腺腫様甲状腺、転移性病変を伴う甲状腺腫瘍で著明高値
  • 甲状腺機能の亢進
  • 甲状腺の破壊
  • 医原性
  • 甲状腺穿刺
  • TSHホルモンの上昇。

低値

  • 医原性

参考

  • 1. SRL
[display]http://www.srl.info/srlinfo/kensa_ref_CD/KENSA/SRL2586.htm



Tg」

  [★]

genetic transformationtransgenesistransgenic
thyroglobulin


TG」

  [★]



antithyroglobulin antibody」

  [★]

抗サイログロブリン抗体抗チログロブリン抗体




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