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deoxythymidine monophosphatedTMPthymidine monophosphatethymidylic acid

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/18 17:56:49」(JST)

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  • Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence.
  • Nikiforov MA1, Shewach DS2.
  • Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1534:165-173.
  • DNA damage response has been characterized as an important mediator of senescence phenotypes induced by activated oncogenes in normal human cells. Depletion of intracellular deoxyribonucleotide pools has been recently recognized as one of the major causes for DNA damage in these cells. Cells undergo
  • PMID 27812878
  • Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis.
  • Municio C1, Soler Palacios B1, Estrada-Capetillo L1, Benguria A2, Dopazo A2, García-Lorenzo E3, Fernández-Arroyo S4, Joven J4, Miranda-Carús ME5, González-Álvaro I3, Puig-Kröger A1.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2016 Dec;75(12):2157-2165. doi: 10.1136/annrheumdis-2015-208736. Epub 2016 Feb 26.
  • OBJECTIVES: Methotrexate (MTX) functions as an antiproliferative agent in cancer and an anti-inflammatory drug in rheumatoid arthritis (RA). Although macrophages critically contribute to RA pathology, their response to MTX remains unknown. As a means to identify MTX response markers, we have explore
  • PMID 26920997
  • X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.
  • Catalano A1, Luciani R2, Carocci A1, Cortesi D2, Pozzi C3, Borsari C2, Ferrari S4, Mangani S5.
  • European journal of medicinal chemistry.Eur J Med Chem.2016 Nov 10;123:649-64. doi: 10.1016/j.ejmech.2016.07.066. Epub 2016 Jul 29.
  • Infections caused by Enterococcus faecalis (Ef) represent nowadays a relevant health problem. We selected Thymidylate synthase (TS) from this organism as a potential specific target for antibacterial therapy. We have previously demonstrated that species-specific inhibition of the protein can be achi
  • PMID 27517810


  • Successful curative resection of gallbladder cancer following S‑1 chemotherapy: A case report and review of the literature
  • 永生 高広,内田 浩一郎,谷口 雅彦,太田 雄,渡邉 賢二,今井 浩二,唐崎 秀則,千葉 篤,及川 賢輔,三代川 斉之,古川 博之
  • Oncology letters. 8(6), 2443-2447, 2014-12
  • … In particular, the gene expression involved in the S-1 metabolic pathway was investigated by assessing the intratumoral dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) and orotate phosphoribosyltransferase gene expression. …
  • NAID 120005621895
  • 大腸癌原発巣における5-FU(5-fuluorouracil)関連酵素発現量の意義
  • 金子 由紀,瀬下 明良,亀岡 信悟
  • 東京女子医科大学雑誌 84(E3), E372-E377, 2014-11-30
  • … 5-FUの代謝に関わる酵素であるThymidylate Synthase(TS)、Dihydropyrimidine Dehydrogenase(DPD)、Orotate Phosphoribosy Transferase(OPRT)の腫瘍内発現による5-FUに対する抗腫瘍効果予測や予後との関連につき議論をされている。 …
  • NAID 110009864196
  • 大腸癌原発巣における5-FU (5-fuluorouracil)関連酵素発現量の意義 (医学部外科学(第2)講座 亀岡信悟教授退任記念特別号)
  • 金子 由紀,瀬下 明良,亀岡 信悟
  • 東京女子医科大学雑誌 = Journal of Tokyo Women's Medical University 84(臨増3), E372-377, 2014-11
  • NAID 40020301931


Thymidylate Synthase(TS,チミジル酸合成酵素)は DNA 合成において重要な酵素であり、DNA 生合成に必要なチミンヌクレオチドを生成するために 5,10-methylenetetrahydrofolate(CH2THF,活性型葉酸)と共に dUMP をメチル化し ...
Figure 2. This figure shows the possible H-bond interactions between the arginines and the UMP in the active site of thymidylate synthase. This can be seen by the faint lines between the blue tips and the red tips. These arginines are ...



先読みthymidine monophosphate
リンク元チミジン一リン酸」「deoxythymidine monophosphate」「thymidylic acid」「チミジル酸」「dTMP

thymidine monophosphate」

  [★] チミジン一リン酸 TMP



thymidine monophosphate, TMP
チミジル酸 thymidylic acid thymidylate
(DNA)デオキシチミジン一リン酸 deoxythymidine monophosphate dTMP

deoxythymidine monophosphate」



dTMPthymidine monophosphatethymidylate

thymidylic acid」


dTMPthymidine monophosphatethymidylateTMP
  • thymidylate



thymidylic acid, thymidylate


  [★] デオキシチミジン一リン酸