関: deoxythymidine monophosphate、dTMP、thymidine monophosphate、thymidylic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/18 17:56:49」(JST)

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Thymidine monophosphate (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA. It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar deoxyribose, and the nucleobase thymine. Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; nevertheless, its symbol often includes a "d" ("dTMP").^[1] Dorland’s Illustrated Medical Dictionary^[2] provides an explanation of the nomenclature variation at its entry for thymidine.

As a substituent, it is called by the prefix thymidylyl-.

References

^ Coghill, Anne M.; Garson, Lorrin R., eds. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.
^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.

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English Journal

Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence.

Nikiforov MA1, Shewach DS2.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1534:165-173.
DNA damage response has been characterized as an important mediator of senescence phenotypes induced by activated oncogenes in normal human cells. Depletion of intracellular deoxyribonucleotide pools has been recently recognized as one of the major causes for DNA damage in these cells. Cells undergo
PMID 27812878

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis.

Municio C1, Soler Palacios B1, Estrada-Capetillo L1, Benguria A2, Dopazo A2, García-Lorenzo E3, Fernández-Arroyo S4, Joven J4, Miranda-Carús ME5, González-Álvaro I3, Puig-Kröger A1.
Annals of the rheumatic diseases.Ann Rheum Dis.2016 Dec;75(12):2157-2165. doi: 10.1136/annrheumdis-2015-208736. Epub 2016 Feb 26.
OBJECTIVES: Methotrexate (MTX) functions as an antiproliferative agent in cancer and an anti-inflammatory drug in rheumatoid arthritis (RA). Although macrophages critically contribute to RA pathology, their response to MTX remains unknown. As a means to identify MTX response markers, we have explore
PMID 26920997

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

Catalano A1, Luciani R2, Carocci A1, Cortesi D2, Pozzi C3, Borsari C2, Ferrari S4, Mangani S5.
European journal of medicinal chemistry.Eur J Med Chem.2016 Nov 10;123:649-64. doi: 10.1016/j.ejmech.2016.07.066. Epub 2016 Jul 29.
Infections caused by Enterococcus faecalis (Ef) represent nowadays a relevant health problem. We selected Thymidylate synthase (TS) from this organism as a potential specific target for antibacterial therapy. We have previously demonstrated that species-specific inhibition of the protein can be achi
PMID 27517810

Japanese Journal

Successful curative resection of gallbladder cancer following S‑1 chemotherapy: A case report and review of the literature

永生高広,内田浩一郎,谷口雅彦,太田雄,渡邉賢二,今井浩二,唐崎秀則,千葉篤,及川賢輔,三代川斉之,古川博之
Oncology letters. 8(6), 2443-2447, 2014-12
… In particular, the gene expression involved in the S-1 metabolic pathway was investigated by assessing the intratumoral dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) and orotate phosphoribosyltransferase gene expression. …
NAID 120005621895

大腸癌原発巣における5-FU(5-fuluorouracil)関連酵素発現量の意義

金子由紀,瀬下明良,亀岡信悟
東京女子医科大学雑誌 84(E3), E372-E377, 2014-11-30
… 5-FUの代謝に関わる酵素であるThymidylate Synthase(TS)、Dihydropyrimidine Dehydrogenase(DPD)、Orotate Phosphoribosy Transferase(OPRT)の腫瘍内発現による5-FUに対する抗腫瘍効果予測や予後との関連につき議論をされている。 …
NAID 110009864196

大腸癌原発巣における5-FU (5-fuluorouracil)関連酵素発現量の意義 (医学部外科学(第2)講座亀岡信悟教授退任記念特別号)

金子由紀,瀬下明良,亀岡信悟
東京女子医科大学雑誌 = Journal of Tokyo Women's Medical University 84(臨増3), E372-377, 2014-11
NAID 40020301931

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★リンクテーブル★

リンク元	「チミジン一リン酸」「deoxythymidine monophosphate」「thymidylic acid」「チミジル酸」「dTMP」

「チミジン一リン酸」

Thymidine monophosphate
Names
	IUPAC name Thymidine monophosphate
Identifiers
Abbreviations	dTMP
Beilstein Reference	3916216
ChEBI	CHEBI:26999
ChEMBL	ChEMBL394429
ChemSpider	10239189
Jmol 3D model	Interactive image
PubChem	16755631
	InChI InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2 Key: GYOZYWVXFNDGLU-UHFFFAOYSA-L ;
	SMILES Cc1cn(C2CC(O)C(COP([O-])([O-])=O)O2)c(:o)[nH]c1:o ;
Properties
Chemical formula	C10H14N2O8P1−
Molar mass	321.2005 g mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references