thromboxane receptor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/29 21:46:58」(JST)

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  • Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model.
  • Reddi BA1, Beltrame JF, Young RL, Wilson DP.
  • Intensive care medicine experimental.Intensive Care Med Exp.2015 Dec;3(1):36. doi: 10.1186/s40635-014-0036-8. Epub 2015 Jan 31.
  • BACKGROUND: Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca(2+)-dependent myosin light-chain kinase promotes and Ca(2+)-independent myosin light-chain phosphatase (MLCP) opposes vascular smooth muscle contraction. The enzyme Rho kinase (R
  • PMID 26215803
  • Characterization of UBO-QIC as a Gαq inhibitor in platelets.
  • Inamdar V1, Patel A1, Manne BK1, Dangelmaier C1, Kunapuli SP1.
  • Platelets.Platelets.2015 Dec;26(8):771-8. doi: 10.3109/09537104.2014.998993. Epub 2015 Mar 3.
  • Gαq plays an important role in platelet activation by agonists such as thrombin, adenosine diphosphate (ADP) and thromboxane. The significance of Gαq signaling in platelets was established using YM254890, a Gαq/11-specific inhibitor and Gαq knockout murine platelets. However, YM-254890 is no lon
  • PMID 25734215
  • Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.
  • Hoefer T1, Armstrong PC1, Finsterbusch M1, Chan MV1, Kirkby NS1, Warner TD2.
  • Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2015 Oct;35(10):2122-33. doi: 10.1161/ATVBAHA.115.306219. Epub 2015 Aug 13.
  • OBJECTIVE: Reduced antiplatelet drug efficacy occurs in conditions of increased platelet turnover, associated with increased proportions of drug-free, that is, uninhibited, platelets. Here, we detail mechanisms by which drug-free platelets promote platelet aggregation in the face of standard antipla
  • PMID 26272940


  • Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.
  • Abe Yuichi,Aly Hussein Hassan,Hiraga Nobuhiko,Imamura Michio,Wakita Takaji,Shimotohno Kunitada,Chayama Kazuaki,Hijikata Makoto
  • Gastroenterology 145(3), 658-667.e11, 2013-09
  • … Small interfering RNA–mediated knockdown of thromboxane A2 synthase (TXAS) and incubation of hepatocytes with a TXAS inhibitor showed that this enzyme is required for production of infectious HCV, but does not affect replication of the HCV genome or particle release. … The TXAS inhibitor and a prostaglandin I2 receptor agonist, which has effects that are opposite those of thromboxane A2, reduced serum levels of HCV and inhibited the infection of human hepatocytes by blood-borne HCV in mice. …
  • NAID 120005324909
  • Thromboxane A2 Mediates Iron-Overload Cardiomyopathy in Mice Through Calcineurin-Nuclear Factor of Activated T Cells Signaling Pathway
  • Lin Heng,Li Hsiao-Fen,Lian Wei-Shiung,Chen Hsi-Hsien,Lan Yi-Fan,Lai Pei-Fang,Cheng Ching-Feng
  • Circulation Journal, 2013
  • … Because thromboxane A2 (TXA2) and prostacyclin are the 2 major prostanoids in the cardiovascular system, and TXA2 plays a major role in vascular atherosclerosis and has pro-inflammatory characteristics, we intended to elucidate the role of TXA2 in iron-overload cardiomyopathy. …
  • NAID 130003361810
  • Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension
  • Nakamura Atsuhiro,Nagaya Noritoshi,Obata Hiroaki,Sakai Katsuya,Sakai Yoshiki,Yoshikawa Masanori,Hamada Kaoru,Matsumoto Kunio,Kimura Hiroshi
  • Circulation Journal, 2013
  • … Therefore, we developed ONO-1301, an orally active, long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. … Kaplan-Meier survival curves demonstrated that the effect of ONO-1301 was equivalent to that of an endothelin receptor antagonist and a phosphodiesterase-5 inhibitor. … Treatment with ONO-1301 significantly decreased urinary 11-dehydro-thromboxane B2 and increased the plasma hepatocyte growth factor concentration. …
  • NAID 130003361765


The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor ...
THROMBOXANE RECEPTOR The chemical function characterization protein various of j. A is and expressed jan family proteins receptors receptors: platelet agonist cardiovascular these anaesthetized, including tp tai is innovations ...






thromboxane receptor


  [★] 受容体

WordNet   license wordnet

「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」