関: TXB2

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/15 16:41:39」(JST)

wiki en

Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.

It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). ^[1]

2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.^[2]

References

^ "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02.
^ Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Anna Petroni, Milena Blasevich, Marco Salami, Nadia Papini, Gian F. Montedoro and Claudio Gallia, Thrombosis Research, 15 April 1995, Volume 78, Issue 2, Pages 151–160, doi:10.1016/0049-3848(95)00043-7

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 止血の概要 overview of hemostasis
2. The epidemiology and pathogenesis of pulmonary arterial hypertension (Group 1)
3. 機械的人工換気の肺障害の炎症メカニズム inflammatory mechanisms of lung injury during mechanical ventilation
4. アスピリンの無効および耐性 nonresponse and resistance to aspirin
5. アンギオテンシン変換酵素阻害剤およびアンギオテンシンII受容体拮抗剤の主な副作用 major side effects of angiotensin converting enzyme inhibitors and angiotensin ii receptor blockers

English Journal

Induced sputum eicosanoids during aspirin bronchial challenge of asthmatic patients with aspirin hypersensitivity.

Mastalerz L1, Celejewska-Wójcik N, Wójcik K, Gielicz A, Januszek R, Cholewa A, Stręk P, Sanak M.
Allergy.Allergy.2014 Nov;69(11):1550-9. doi: 10.1111/all.12512. Epub 2014 Sep 12.
BACKGROUND: Altered metabolism of eicosanoids is a characteristic finding in aspirin-exacerbated respiratory disease (AERD). Bronchial challenge with lysyl-aspirin can be used as a confirmatory diagnostic test for this clinical condition. Induced sputum allows to measure mediators of asthmatic infla
PMID 25123806

Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?

Varnell CD Jr1, Goldstein SL, Yee DL, Teruya J, Guyer KE, Siddiqui S, Jefferies JL.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Nov;61(11):2074-6. doi: 10.1002/pbc.25089. Epub 2014 May 7.
Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2 . 128 individuals (2 months to 18 years) were identif
PMID 24803308

Effect of acetylsalicylic acid on platelet activation and oxidative profile in a set of Brazilian patients with type 2 diabetes mellitus.

Duarte RC1, Gonçalves LH, Campos FM, Filho OA, Alves MT, Fernandes AP, Borges KB, Dusse LM, Faria MC, Gonçalves GS, Bosco AA, Sandrim VC, Carvalho MG.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2014 Oct 16. [Epub ahead of print]
Type 2 diabetes mellitus (DM2) is a metabolic disorder associated with hyperactivation of platelets, increased formation of platelet microparticles (PMPs) and oxidative stress that are related to cardiovascular complications. Acetylsalicylic acid (ASA) is an antiplatelet agent used in the prevention
PMID 25325344

Japanese Journal

Dietary Fish Oil and Zinc Reduced Plasma Prostaglandin E2 Content by Inhibiting Phospholipase A2 Production in Broilers

, , , , , ,
The Journal of Poultry Science 51(1), 66-70, 2014
… Fish oil significantly decreased the levels of serum total cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol of broilers, decreased the contents of plasma prostaglandin E2, thromboxane B2, and phospholipase A2 in broilers when compared with corn oil. …
NAID 130004446430

Vasomotor Effects of Acetylcholine, Bradykinin, Noradrenaline, 5-Hydroxytryptamine, Histamine and Angiotensin II on the Mouse Basilar Artery

, , , , , ,
Journal of Veterinary Medical Science 76(10), 1339-1345, 2014
… ACh and BK induced endothelium-dependent relaxation of precontracted arteries with U-46619 (a thromboxane A2 analogue). … L-NNA and HOE140 (a B2 antagonist) shifted the concentration-response curve for BK to the right, whereas des-Arg9-[Leu8]-BK (a B1 antagonist) and indomethacin (a cyclooxygenase inhibitor) had no significant effect. …
NAID 130004432214

Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A2 Levels in Streptozotocin-Induced Diabetic Mice

, , , , ,
Biological and Pharmaceutical Bulletin 37(6), 1056-1061, 2014
… Aorta reactivity was determined in organ chambers, and we measured NO production and thromboxane B2 (TXB2; …
NAID 130004147353

「TXB2」

Thromboxane B2
Identifiers
CAS number	54397-85-2
PubChem	5283137
MeSH	Thromboxane+B2
Properties
Molecular formula	C20H34O6
Molar mass	370.48 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	(verify) (what is: /?)
	Infobox references