WordNet

an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot (同)thrombokinase, factor_III
coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors (同)factor_X

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/06 01:26:37」(JST)

wiki en

Thromboplastin is a plasma protein aiding blood coagulation through conversion of prothrombin to thrombin.It is a complex enzyme that is found in brain, lung, and other tissues and especially in blood platelets and that functions in the conversion of prothrombin to thrombin in the clotting of blood—called also thrombokinase

Although sometimes used as a synonym for the protein tissue factor (with its official name "Coagulation factor III [thromboplastin, tissue factor]"), this is a misconception. Historically, thromboplastin was a lab reagent, usually derived from placental sources, used to assay prothrombin times (PT time).^[1] Thromboplastin, by itself, could activate the extrinsic coagulation pathway. When manipulated in the laboratory, a derivative could be created called partial thromboplastin. Partial thromboplastin was used to measure the intrinsic pathway. This test is called the aPTT, or activated partial thromboplastin time. It was not until much later that the subcomponents of thromboplastin and partial thromboplastin were identified. Thromboplastin is the combination of both phospholipids and tissue factor, both needed in the activation of the extrinsic pathway. However, partial thromboplastin is just phospholipids, and not tissue factor.

Currently, recombinant tissue factor is available and used in some PT assays. Placental derivatives are still available and used in some laboratories. Phospholipid is available as an independent reagent or in combination with tissue factor as thromboplastin. Complete thromboplastin consists of tissue factor, phospholipids (since platelets were removed from blood sample being tested), and CaCl₂ to reintroduce calcium ions that were chelated by sodium citrate originally used to prevent coagulation of the sample blood during transportation and/or storage.

References[edit]

^ van den Besselaar AM, Chantarangkul V, Tripodi A (July 2010). "Thromboplastin standards". Biologicals 38 (4): 430–6. doi:10.1016/j.biologicals.2010.02.012. PMID 20338779.

External links[edit]

Thromboplastin at the US National Library of Medicine Medical Subject Headings (MeSH)

This medical article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 凝固検査の臨床使用 clinical use of coagulation tests
2. 出血性素因を有する成人患者へのアプローチ approach to the adult patient with a bleeding diathesis
3. 成人における確定診断を得られていない低血圧やショックの評価および初期アプローチ evaluation of and initial approach to the adult patient with undifferentiated hypotension and shock
4. 術前の止血状態評価 preoperative assessment of hemostasis
5. 健康な患者の術前医学的評価 preoperative medical evaluation of the healthy patient

English Journal

Hypofibrinogenemia induced by tigecycline: a potentially life-threatening coagulation disorder.

Sabanis N1, Paschou E, Gavriilaki E, Kalaitzoglou A, Vasileiou S.
Infectious diseases (London, England).Infect Dis (Lond).2015 Oct;47(10):747-50. doi: 10.3109/23744235.2015.1043942. Epub 2015 May 8.
A 74-year-old female patient with end-stage renal disease, undergoing periodic hemodialysis, was hospitalized due to infection by multidrug-resistant Acinetobacter baumannii after hip replacement surgery. She was treated with tigecycline, a glycylcycline agent. Subsequently she developed coagulation
PMID 25951751

Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria.

Kim JA1, Kim S2, Kim JE3, Gu JY3, Yoo HJ3, Kang HR4, Kim HK5.
Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2015 Sep;7(5):476-82. doi: 10.4168/aair.2015.7.5.476. Epub 2015 May 22.
PURPOSE: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation as
PMID 26122507

Coagulation defects associated with massive blood transfusion: A large multicenter study.

Yang JC1, Sun Y1, Xu CX2, Dang QL3, Li L4, Xu YG5, Song YJ1, Yan H6.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4179-86. doi: 10.3892/mmr.2015.3971. Epub 2015 Jun 22.
The variations in the coagulation indices of patients receiving massive blood transfusion were investigated across 20 large‑scale general hospitals in China. The data of 1,601 surgical inpatients receiving massive transfusion were retrospectively collected and the trends in the platelet counts a
PMID 26095897

Japanese Journal

ダビガトラン服用患者の抜歯に関する検討

日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 62(6), 315-320, 2016-06
NAID 40020892710

PT,APTT : 止血異常のスクリーニング検査としてのPT,APTT (今月の特集深く知ろう! 血栓止血検査)

臨床検査 60(2), 130-135, 2016-02
NAID 40020719839

抜歯後出血を契機として明らかとなった後天性血友病の1例

日本口腔外科学会雑誌 62(5), 262-266, 2016
NAID 130005165619

Related Pictures

★リンクテーブル★

リンク元	「トロンボプラスチン」「prothrombinase」「blood coagulation factor III」「coagulation factor III」
拡張検索	「activated partial thromboplastin time」「plasmathromboplastinantecedent」「plasma thromboplastin antecedent」