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- 1. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
- 2. 静脈血栓症が確認された患者の後天的危険因子および遺伝的危険因子の評価 evaluating patients with established venous thromboembolism for acquired and inherited risk factors
- 3. 先天性血栓性素因のマネージメント management of inherited thrombophilia
- 4. 無症候性患者における先天性血栓性素因のスクリーニング screening for inherited thrombophilia in asymptomatic individuals
- 5. 悪性腫瘍に関連した凝固亢進状態の病因 pathogenesis of the hypercoagulable state associated with malignancy
- Does anticoagulant therapy improve pregnancy outcome equally, regardless of specific thrombophilia type?
- Kovac M, Mikovic Z, Mitic G, Djordjevic V, Mandic V, Rakicevic L, Radojkovic D.Author information 1Faculty of Medicine, University of Belgrade, Belgrade, Serbia.AbstractThe study was conducted to evaluate the effect of anticoagulant therapy in women with thrombophilia and to detect the possible differences among carriers of mutations (factor V [FV] Leiden and FIIG20210) and those with natural anticoagulant deficiency. The 4-year prospective investigation included 85 pregnant women, with a history of recurrent fetal loss (RFL). They were treated with prophylactic doses of low-molecular-weight heparin (nadroparin) starting from 6 to 8 weeks of gestation. Pregnancy outcomes were evaluated based on the thrombophilia type. Carriers of thrombophilic mutations had a live birth rate of 93%, compared to 41.6% for women with natural anticoagulant deficiencies. Significant differences between the groups were also observed for intrauterine fetal death, intrauterine growth restriction, and postpartum thrombosis. The optimal therapy for women with natural anticoagulant deficiency and RFL remains unclear and future prospective study with a large number of patients is required to determine the best treatment for these severe thrombophilic conditions.
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.Clin Appl Thromb Hemost.2014 Mar;20(2):184-9. doi: 10.1177/1076029612468940. Epub 2012 Dec 21.
- The study was conducted to evaluate the effect of anticoagulant therapy in women with thrombophilia and to detect the possible differences among carriers of mutations (factor V [FV] Leiden and FIIG20210) and those with natural anticoagulant deficiency. The 4-year prospective investigation included 8
- PMID 23262970
- The impact of inherited thrombophilia on first trimester combined aneuploidy screening test parameters.
- Karsli MF, Baser E, Seckin KD, Yeral Mİ, Togrul C, Ugur M.Author information Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.AbstractAbstract Objective: To determine whether inherited thrombophilia affects components of first trimester combined aneuploidy screening test. Method: A case-control study was performed between January 1st and December 31st 2011, at a tertiary referral hospital. Singleton pregnancies with inherited thrombophilia that underwent first trimester (11-13(+6) week) combined aneuploidy screening test were included in the study. Pregnancy associated plasma protein-A (PAPP-A), free beta-human chorionic gonadotropin (fbHCG) and fetal nuchal translucency (NT) were compared between the study group and controls. Results: Within the study period, 15 881 women with singleton pregnancies had a combined first trimester aneuploidy screening test at our institution. Among these, 207 women met the inclusion criteria. A control group that comprised 625 women with similar gestational age was generated, using a 1:3 ratio. PAPP-A levels were significantly higher, whereas fbHCG levels and fetal NT measurements were lower in women with inherited thrombophilia (p < 0.001). Conclusion: Our study suggested that PAPP-A, free b-HCG and NT MoM levels display alterations in women with inherited thrombophilia. Future trials are needed to assess the need for readjustment of risk in these patients.
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2014 Mar;27(4):346-9. doi: 10.3109/14767058.2013.818123. Epub 2013 Jul 16.
- Abstract Objective: To determine whether inherited thrombophilia affects components of first trimester combined aneuploidy screening test. Method: A case-control study was performed between January 1st and December 31st 2011, at a tertiary referral hospital. Singleton pregnancies with inherited thro
- PMID 23795618
- Thrombophilia testing in children: A 7 year experience.
- Mahajerin A, Obasaju P, Eckert G, Vik TA, Mehta R, Heiny M.Author information Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, Indiana.AbstractBACKGROUND: Incidence of venous thromboembolism (VTE) in children is reported to be increasing. We examined thrombophilia testing results in children with VTE that presented in inpatient and outpatient settings to explore patterns of thrombophilia testing.
- Pediatric blood & cancer.Pediatr Blood Cancer.2014 Mar;61(3):523-7. doi: 10.1002/pbc.24846. Epub 2013 Nov 19.
- BACKGROUND: Incidence of venous thromboembolism (VTE) in children is reported to be increasing. We examined thrombophilia testing results in children with VTE that presented in inpatient and outpatient settings to explore patterns of thrombophilia testing.PROCEDURE: Patients/Methods: Children, ages
- PMID 24249220
- 日本血液疾病 : 从血栓与止血的角度来看 (特辑 日中两国血液病的诊断与治疗)
- 嶋 绿倫
- 日中医学 : (公財)日中医学協会機関誌 : bulletin of the Japan China Medical Association 29(4), 44-48, 2015-02
- NAID 40020382609
- 日本の血液疾患について : 血栓・止血的見地から (特集 日中における血液疾患診療)
- 嶋 緑倫
- 日中医学 : (公財)日中医学協会機関誌 : bulletin of the Japan China Medical Association 29(4), 20-25, 2015-02
- NAID 40020382373
- 日本人における先天性血栓性素因 : 欧米との比較 (特集 血栓止血性疾患診療の最前線)
- 宮田 敏行,丸山 慶子
- 臨床血液 55(8), 908-916, 2014-08
- NAID 40020195463
- Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). Such abnormalities can be identified in 50% of people who have ...
- 29 Mar 2012 ... What is Thrombophilia? Thrombophilias can be defined as a group of inherited or acquired disorders that increase a person's risk of developing thrombosis ( abnormal “blood clotting”) in the veins or arteries. The human body ...
- thrombophilia, thrombotic tendency