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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/06 23:56:12」(JST)

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Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.

Wang Y1, Hayes V1, Jarocha D2, Sim X3, Harper DC4, Fuentes R1, Sullivan SK1, Gadue P3, Chou ST3, Torok-Storb BJ5, Marks MS6, French DL3, Poncz M3.
Blood.Blood.2015 Jun 4;125(23):3627-36. doi: 10.1182/blood-2014-08-593053. Epub 2015 Apr 7.
Thrombopoiesis is the process by which megakaryocytes release platelets that circulate as uniform small, disc-shaped anucleate cytoplasmic fragments with critical roles in hemostasis and related biology. The exact mechanism of thrombopoiesis and the maturation pathways of platelets released into the
PMID 25852052

Immature platelet fraction measurement is influenced by platelet size and is a useful parameter for discrimination of macrothrombocytopenia.

Miyazaki K, Koike Y, Kunishima S, Ishii R, Danbara M, Horie R, Yatomi Y, Higashihara M.
Hematology (Amsterdam, Netherlands).Hematology.2015 Jun 2. [Epub ahead of print]
Background Reticulated platelets (RPs) as measured using flow cytometry are useful parameters of thrombopoiesis; however, difficulties remain with standardization between laboratories. On the other hand, immature platelet fraction (IPF) measurement, as determined using an automated hematology analyz
PMID 26035037

Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice.

Cao Y1, Cai J1, Zhang S1, Yuan N1, Li X1, Fang Y1, Song L1, Shang M1, Liu S1, Zhao W1, Hu S1, Wang J2.
Experimental hematology.Exp Hematol.2015 Jun;43(6):488-94. doi: 10.1016/j.exphem.2015.01.001. Epub 2015 Jan 13.
During hematopoiesis, megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis are regulated at multiple stages, which involve successive lineage commitment steps and proceed with polyploidization, maturation, and organized fragmentation of the cytoplasm, leading to the release of platele
PMID 25591498

Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes