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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/14 23:49:00」(JST)
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English Journal
- Sensitive spectrofluorimetric and spectrophotometric methods for the determination of thonzylamine hydrochloride in pharmaceutical preparations based on coupling with dimethylbarbituric acid in presence of dicyclohexylcarbodiimide.
- Sabry SM, Abdel-Hay MH, Barary MH, Belal TS.Author information Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.AbstractTwo sensitive and selective spectrophotometric and spectrofluoimetric procedures were developed for the determination of thonzylamine hydrochloride (THAH) in tablets and nasal drops. The methods are based on König reaction which resulted in an orange-yellow fluorescent product. The orange-yellow product of the interaction between the dicyclohexylcarbodiimide (DCC), THAH and dimethylbarbituric acid (DMBA) showed an absorption maximum at 492 nm, a first-derivative signal at 494 nm and a fluorescence emission peak at 518 nm (lambda(ex)=492 nm). The orange-yellow color was found to be stable for at least 2 h. The reaction conditions were studied and optimized. The reaction obeys Beer's law over the ranges 8-20 and 0.2-2.0 microg ml(-1) for the derivative spectrophotometric and fluorimetric measurements, respectively. The detection limits were found to be 0.29 and 0.018 microg ml(-1) for the spectrophotometric and fluorimetric measurements, respectively. The proposed methods were applied to the analysis of pharmaceutical formulations containing THAH, either alone or in combination with naphazoline nitrate.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2000 Mar;22(2):257-64.
- Two sensitive and selective spectrophotometric and spectrofluoimetric procedures were developed for the determination of thonzylamine hydrochloride (THAH) in tablets and nasal drops. The methods are based on König reaction which resulted in an orange-yellow fluorescent product. The orange-yellow pr
- PMID 10719908
- [4-[Benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds with selective antagonistic activity against H1-histamine receptors].
- Mossini F, Maggiali C, Morini G, Impicciatore M, Morini G, Molina E.AbstractThis paper describes the synthesis of 2- and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds and their antihistaminic properties studied on isolated guinea-pig ileum. Calculated pA2 values show that the antihistaminic activity of 4-[p.methoxybenzyl-(2-dimethylaminoethyl)amino]pyrimidine is specific and potent (8-10 times higher than that of thonzylamine).
- Il Farmaco; edizione scientifica.Farmaco Sci.1984 Mar;39(3):189-99.
- This paper describes the synthesis of 2- and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds and their antihistaminic properties studied on isolated guinea-pig ileum. Calculated pA2 values show that the antihistaminic activity of 4-[p.methoxybenzyl-(2-dimethylaminoethyl)amino]pyrimidine i
- PMID 6143687
- Carbon-13 magnetic resonance spectroscopy of drugs II: antihistamines.
- Chang CJ, Peck GE.AbstractThe natural abundance carbon-13 magnetic resonance spectra of a series of antihistamines (pheniramine, chlorpheniramine, methapyrilene, tripelennamine, pyrilamine, and thonzylamine) were detemined using the pulse Fourier transform technique. The chemical shifts were assigned with the aid of long-range carbon-13-hydrogen coupling constants.
- Journal of pharmaceutical sciences.J Pharm Sci.1976 Jul;65(7):1019-23.
- The natural abundance carbon-13 magnetic resonance spectra of a series of antihistamines (pheniramine, chlorpheniramine, methapyrilene, tripelennamine, pyrilamine, and thonzylamine) were detemined using the pulse Fourier transform technique. The chemical shifts were assigned with the aid of long-ran
- PMID 8624
Japanese Journal
- 11-β-hydroxylase inhibitorを用いた小児の間脳-下垂体-副腎皮質系ホルモン分泌機構に関する研究:第一編 血中11-β-hydroxylase inhibitor (metyraponeとreduced metyrapone) のGC/MS測定法の確立及びmetyraponeの生体内代謝と作用の検討
- 市村 一義
- 日本内分泌学会雑誌 59(5), 715-737, 1983
- … times dilution.) <BR>The serum samples, containing a fixed amount (200 ng-2μg/tube) of the internal standard (thonzylamine hydrochloride) were alkalinized with 0.1N NaOH at a pH above 7.8. …
- NAID 130001937888
- 塩酸トンジルアミンのそう痒をともなう皮膚疾患にたいする治療効果:—Controlled Study, Cross Over Methodによる検討—
- 藤田 知道
- 西日本皮膚科 40(5), 1030-1037, 1978
- NAID 130004472498
- o-アミノチオフェノールによるけい光分析(第2報) : 塩酸トンジルアミンのけい光定量
- 中野 三郎 [他],谷口 寛一,古橋 崇子
- 藥學雜誌 92(4), 411-416, 1972-04-25
- … Fluorometric determination of thonzylamine hydrochloride (I) with o-aminothiophenol (II) was investigated. …
- NAID 110003651255
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| リンク元 | 「トンジルアミン」 |
| 拡張検索 | 「thonzylamine hydrochloride」 |