WordNet

a complex consisting of an organic base in association with hydrogen chloride
a tranquilizer (trade name Navane) used to treat schizophrenia (同)Navane

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/19 16:51:50」(JST)

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Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967^[1] by Pfizer.^[2]

Thiothixene is the only first generation typical thioxanthene antipsychotic approved for use in the United States.

Chemistry

Bloom, B. M.; Muren, J. F.; 1967, U.S. Patent 3,310,553

References

^ http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 520. ISBN 3-527-31058-4.

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1. 第1世代抗精神病剤：薬理学、投与、および副作用の比較 first generation antipsychotic medications pharmacology administration and comparative side effects
2. 統合失調症に対する薬物療法：副作用マネージメント pharmacotherapy for schizophrenia side effect management
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English Journal

Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system.

Aly FA1, al-Tamimi SA, Alwarthan AA.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.Anal Sci.2001 Nov;17(11):1257-61.
PMID 11759505

Psychotropic agent-induced black hairy tongue.

Heymann WR1.
Cutis.Cutis.2000 Jul;66(1):25-6.
PMID 10916687

A case report of venlafaxine toxicity.

Fantaskey A1, Burkhart KK.
Journal of toxicology. Clinical toxicology.J Toxicol Clin Toxicol.1995;33(4):359-61.
PMID 7629904

Japanese Journal

Flow-injection Chemiluminometric Determination of Some Thioxanthene Derivatives in Pharmaceutical Formulations and Biological Fluids Using the [Ru(dipy)32+]-Ce(IV) System.

Analytical Sciences 17(11), 1257-1261, 2001
NAID 130004440331

「チオチキセン」

Thiothixene
Systematic (IUPAC) name
	(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names	Navane
AHFS/Drugs.com	monograph
MedlinePlus	a682867
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	10-20 hours
Identifiers
CAS Registry Number	5591-45-7
ATC code	N05AF04
PubChem	CID 941651
IUPHAR ligand	212
DrugBank	DB01623
ChemSpider	819430
UNII	7318FJ13YJ
ChEMBL	CHEMBL1201
Chemical data
Formula	C23H29N3O2S2
Molecular mass	443.627 g/mol
	SMILES O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4;
	InChI InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- ; Key:GFBKORZTTCHDGY-UWVJOHFNSA-N ;
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　　[★]

英: tiotixene
ラ: tiotixenum
化: 塩酸チオチキセン thiothixene hydrochloride
商: Navane
関

「tiotixene」

　　[★]

チオチキセン

関: thiothixene、thiothixene hydrochloride

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

[1] ttp://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm

[isbn3-527-31058-4-2] José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 520. ISBN 3-527-31058-4.

リンク元	「チオチキセン」「tiotixene」
関連記事	「hydrochloride」

匿名

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案内

案内

thiothixene hydrochloride