thiothixene

チオチキセン 　

WordNet

1. a tranquilizer (trade name Navane) used to treat schizophrenia (同)Navane

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/07 00:03:35」(JST)

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Thiothixene

Systematic (IUPAC) name
(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names	Navane
AHFS/Drugs.com	monograph
MedlinePlus	a682867
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	10-20 hours
Identifiers
CAS number	5591-45-7 Y
ATC code	N05AF04
PubChem	CID 941651
IUPHAR ligand	212
DrugBank	DB01623
ChemSpider	819430 Y
UNII	7318FJ13YJ Y
ChEMBL	CHEMBL1201 Y
Chemical data
Formula	C23H29N3O2S2
Mol. mass	443.627 g/mol
SMILES O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4
InChI InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- Y Key:GFBKORZTTCHDGY-UWVJOHFNSA-N Y
Y (what is this?)  (verify)

Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967 by Pfizer.

Thiothixene is the only first generation typical thioxanthene antipsychotic approved for use in the United States.

Chemistry

• Bloom, B. M.; Muren, J. F.; 1967, U.S. Patent 3,310,553

See also:

• J.F. Muren, B.M. Bloom, DE 1470157  (1963).
• Chas. Pfizer & Co., BE 647066  (1964).
• Muren, James F.; Bloom, Barry M. (1970). "Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides". Journal of Medicinal Chemistry 13 (1): 17. doi:10.1021/jm00295a005. PMID 5412109. 

See also

• Typical antipsychotic
• Thioxanthene

References

UpToDate Contents

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• 1. 第1世代抗精神病剤：薬理学、投与、および副作用の比較first generation antipsychotic medications pharmacology administration and comparative side effects [show details]
  …low-potency drugs: The high-potency FGAs (fluphenazine, haloperidol, loxapine, perphenazine, pimozide, thiothixene, and trifluoperazine) are dosed in the range of 1 to 10s of milligrams and have low activity at …
• 2. 抗利尿ホルモン不適合分泌（SIADH）症候群の病態生理および病因pathophysiology and etiology of the syndrome of inappropriate antidiuretic hormone secretion siadh [show details]
  …been associated with the SIADH. These include vincristine, vinblastine, vinorelbine, cisplatin, thiothixene, thioridazine, haloperidol, amitriptyline, monoamine oxidase inhibitors, melphalan, ifosfamide …
• 3. 産後精神病の治療treatment of postpartum psychosis [show details]
  …limitations), we prefer the high-potency agents, such as haloperidol, perphenazine, trifluoperazine, and thiothixene. The decision as to which drug to use should be made on a case-by-case basis based on side effect…
• 4. 妊娠女性における双極性障害：躁病および軽躁の治療bipolar disorder in pregnant women treatment of mania and hypomania [show details]
  …are reasonable alternatives to haloperidol include chlorpromazine, fluphenazine, perphenazine, thiothixene, and trifluoperazine . Clinicians can expect that response to a first-generation antipsychotic …
• 5. 統合失調症に対する薬物療法：副作用マネージメントpharmacotherapy for schizophrenia side effect management [show details]
  …potential for causing EPS. They are common with some antipsychotics (eg, haloperidol, fluphenazine, thiothixene, and trifluoperazine), and uncommon with others (quetiapine, clozapine, and iloperidone). Patients …

English Journal

• Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

• Slawson MH1,2, Johnson-Davis KL3.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1383:49-57. doi: 10.1007/978-1-4939-3252-8_6.
• Haloperidol, fluphenazine, perphenazine, and thiothixene are "typical" antipsychotic drugs that are used in the treatment of schizophrenia and other psychiatric disorders. The monitoring of the use of these drugs has applications in therapeutic drug monitoring and overdose situations. LC-MS/MS is us
• PMID 26660173

• Thiothixene in the Management of Delirium: A Case Series.

• Leung JG1, Dare FY1, Flowers LM1, Murphy LL1, Sukiennik EM1, Philbrick KL1, Rasmussen KG2.
• Psychosomatics.Psychosomatics.2015 Sep-Oct;56(5):542-6. doi: 10.1016/j.psym.2015.02.003. Epub 2015 Feb 16.
• BACKGROUND: Pharmacologic strategies are often required to help manage agitated patients with delirium. First-and second-generation antipsychotic medications (such as haloperidol, quetiapine, and olanzapine) are commonly used.OBJECTIVE: On the psychiatric consultation service in our hospital, thioth
• PMID 26002225

• Antipsychotic drugs and safety concerns for breast-feeding infants.

• Parikh T1, Goyal D1, Scarff JR1, Lippmann S1.
• Southern medical journal.South Med J.2014 Nov;107(11):686-8. doi: 10.14423/SMJ.0000000000000190.
• Antipsychotic drugs prescribed to treat psychiatric symptoms during the postpartum period are secreted into breast milk. Because breast-feeding is crucial to infant development, it is important to select a medication that poses the fewest adverse consequences. Aripiprazole, haloperidol, perphenazine
• PMID 25365434

Japanese Journal

• Thiothixeneの臨床効果と副作用の検討

• 猪鹿倉 武 [他]
• 臨牀と研究 53(4), p1246-1262, 1976-04
• NAID 40003784237

• 精神分裂病に対するThiothixene(NAVANE)

• 斎藤 昌治 [他]
• 臨牀と研究 53(2), p594-598, 1976-02
• NAID 40003784310

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thiothixene、thiothixene hydrochloride