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「an antineoplastic drug used to treat acute leukemias」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/25 10:42:18」(JST)

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  • Cytosine derivatized bis(2,2'-bithienyl)methane molecularly imprinted polymer for selective recognition of 6-thioguanine, an antitumor drug.
  • Huynh TP1, Wojnarowicz A2, Sosnowska M1, Srebnik S3, Benincori T4, Sannicolò F5, D'Souza F6, Kutner W7.
  • Biosensors & bioelectronics.Biosens Bioelectron.2015 Aug 15;70:153-60. doi: 10.1016/j.bios.2015.03.001. Epub 2015 Mar 12.
  • A molecularly imprinted polymer (MIP) was designed and synthesized to serve as a functional material for selective recognition of 6-thioguanine (6TG), an antitumor drug. For that, the newly synthesized functional monomer, cytosine-bis(2,2'-bithienyl)-(4-carboxyphenyl)methane ester (Cyt-S4), revealed
  • PMID 25805629
  • Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.
  • Chiker S1, Pennaneach V, Loew D, Dingli F, Biard D, Cordelières FP, Gemble S, Vacher S, Bieche I, Hall J, Fernet M.
  • Cell cycle (Georgetown, Tex.).Cell Cycle.2015 Aug 3:0. [Epub ahead of print]
  • Cyclin dependent kinase 5 (Cdk5) is a determinant of PARP inhibitor and ionizing radiation (IR) sensitivity. Here we show that Cdk5-depleted (Cdk5-shRNA) HeLa cells show higher sensitivity to S-phase irradiation, chronic hydroxyurea exposure, and 5-fluorouracil and 6-thioguanine treatment, with hydr
  • PMID 26237679
  • 6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice.
  • Jeanbart L1, Kourtis IC, van der Vlies AJ, Swartz MA, Hubbell JA.
  • Cancer immunology, immunotherapy : CII.Cancer Immunol Immunother.2015 Aug;64(8):1033-46. doi: 10.1007/s00262-015-1702-8. Epub 2015 May 16.
  • Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress effector T cell responses and can reduce the efficacy of cancer immunotherapies. We previously showed that ultra-small polymer nanoparticles efficiently drain to the lymphatics after intra
  • PMID 25982370


  • The Achievement of Shuttle Vector Techniques in Mammalian Cell Mutation Research
  • Yagi Takashi
  • Genes and Environment 35(4), 93-98, 2013
  • … Geneticists established a method to detect gene mutation as 8-azaguanine or 6-thioguanine resistance after cells had been exposed to radiation or chemicals. …
  • NAID 130004481205
  • The Blood Concentration and Therapeutic Efficacy of Azathioprine in Patients Receiving Infliximab Combination Therapy for Refractory Crohn's Disease : A Clinical Study
  • SATOH Mitsutoshi,YAMAUCHI Takiyo,DOI Hirokazu,MASAKA Toru,SUZUKI Yasuo
  • 応用薬理 82(1), 9-16, 2012-04-06
  • NAID 10030512797
  • Electroanalysis and Simultaneous Determination of 6-Thioguanine in the Presence of Uric Acid and Folic Acid Using a Modified Carbon Nanotube Paste Electrode
  • Beitollahi Hadi,Raoof Jahan-Bakhsh,Hosseinzadeh Rahman
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 27(10), 991-997, 2011-10-10
  • NAID 10029881038


thioguanine 略号: 6-TG 標準治療: 急性リンパ球性白血病(寛解維持) その他の治療(二次薬): 急性骨髄単球性白血病 慢性骨髄性白血病 急性骨髄性白血病 備考: 商品名 企業名 効能または効果 詳細 情報 Tabloid Glaxo 参考: ...
[6-Thioguanine] [154-42-7] | 価格や在庫、物性値などの詳細情報ページです。 ... ・川口の在庫は即日,つくばの在庫は2〜3日以内の出荷となります。 ・詳細につきましては,お手数ですが営業部までお問い合わせください。



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thioguanine derivatives」


Azathio- prine; Mercaptopurine