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English Journal

Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes.

Ramos Gomes F1, Romaniello V2, Sánchez A2, Weber C1, Narayanan P1, Psol M1, Pardo LA3.
The Journal of biological chemistry.J Biol Chem.2015 Dec 18;290(51):30351-65. doi: 10.1074/jbc.M115.668749. Epub 2015 Oct 30.
KV10.1 is a voltage-gated potassium channel expressed selectively in the mammalian brain but also aberrantly in cancer cells. In this study we identified short splice variants of KV10.1 resulting from exon-skipping events (E65 and E70) in human brain and cancer cell lines. The presence of the varian
PMID 26518875

Wang K1, Pan H1, Jiang J2.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Dec 7;21(50):18461-5. doi: 10.1002/chem.201504050. Epub 2015 Nov 3.
The role of O2 within the synthesis of phthalocyanines (Pcs) has remained unclear in the past century. Here, we demonstrate that O2 , in cooperation with the solvent n-pentanol, participates in the cyclic tetramerization of phthalonitriles over the half-sandwich complex template [Lu(Pc)(acac)] (acac
PMID 26526528

DIMERIZATION OF THE SP-1 REGION OF HIV-1 GAG INDUCES A HELICAL CONFORMATION AND ASSOCIATION INTO HELICAL BUNDLES: IMPLICATIONS FOR PARTICLE ASSEMBLY.

Datta SA1, Clark PK2, Fan L3, Ma B4, Harvin DP5, Sowder RC 2nd6, Nussinov R7, Wang YX8, Rein A1.
Journal of virology.J Virol.2015 Dec 4. pii: JVI.02061-15. [Epub ahead of print]
HIV-1 immature particle (VLP) assembly is mediated largely by interactions between the capsid (CA) domains of Gag molecules, but is facilitated by binding of the nucleocapsid (NC) domain to nucleic acid. We previously investigated the role of SP1, a "spacer" between CA and NC, in VLP assembly. We fo
PMID 26637452

Intra- versus Inter-dimer Charge Inhomogeneity in the Triangular Lattice Compounds of β'-Cs[Pd(dmit)₂]₂ : A Degree of Freedom Characteristic of an Interchange of Energy Levels in the Molecular Orbitals