関: dihydrofolate reductase

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1. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く）disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency [show details]
…following. All are extremely rare with the exception of glucose-6-phosphate dehydrogenase deficiency. Glucose-6-phosphate dehydrogenase (G6PD) deficiency – The most common abnormality in this system is G6PD …
2. メタノールおよびエチレングリコール中毒methanol and ethylene glycol poisoning [show details]
… normal . Elimination of formate, the toxic metabolite of methanol, is partially dependent upon tetrahydrofolate, and is thought to accelerate following folic acid administration . Pyridoxine and thiamine … primarily by alcohol dehydrogenase and aldehyde dehydrogenase) .…
3. 乳酸脱水素酵素欠損症lactate dehydrogenase deficiency [show details]
…gluconeogenesis by the liver. The M isoform is a product of the lactate dehydrogenase A (LDHA) gene, located at 11p15 . The lactate dehydrogenase B (LDHB) gene that encodes the H isoform has been mapped to chromosome …
4. グルコース-6-リン酸脱水素酵素（G6PD）欠損症の遺伝学的特徴および病態生理genetics and pathophysiology of glucose 6 phosphate dehydrogenase g6pd deficiency [show details]
… Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked disorder, is the most common enzymatic disorder of red blood cells in humans, affecting more than 400 million people worldwide . The clinical …
5. グルコース-6-リン酸脱水素酵素（G6PD）欠損症の診断とマネージメントdiagnosis and management of glucose 6 phosphate dehydrogenase g6pd deficiency [show details]
… Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder caused by a genetic defect in the red blood cell (RBC) enzyme G6PD, which generates NADPH and protects RBCs from oxidative …

English Journal

Mitochondrial Methylene Tetrahydrofolate Dehydrogenase (MTHFD2) Overexpression is Associated with Tumor Cell Proliferation and is a Novel Target for Drug Development.

Tedeschi PM1, Vazquez A2, Kerrigan JE3, Bertino JR4.
Molecular cancer research : MCR.Mol Cancer Res.2015 Jun 22. pii: molcanres.0117.2015. [Epub ahead of print]
Rapidly proliferating tumors attempt to meet the demands for nucleotide biosynthesis by up regulating folate pathways that provide the building blocks for pyrimidine and purine biosynthesis. In particular, the key role of mitochondrial folate enzymes in providing formate for de novo purine synthesis
PMID 26101208

Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities.

Sah S1, Varshney U1,2.
Biochemistry.Biochemistry.2015 Jun 9;54(22):3504-13. doi: 10.1021/acs.biochem.5b00400. Epub 2015 May 28.
Methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) catalyzes interconversion of 5,10-methylene-tetrahydrofolate and 10-formyl-tetrahydrofolate in the one-carbon metabolic pathway. In some organisms, the essential requirement of 10-formyl-tetrahydrofolate may also be fulfilled by formyltet
PMID 25988590

Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes.

Väremo L1, Scheele C2, Broholm C3, Mardinoglu A1, Kampf C4, Asplund A4, Nookaew I1, Uhlén M5, Pedersen BK3, Nielsen J6.
Cell reports.Cell Rep.2015 May 12;11(6):921-33. doi: 10.1016/j.celrep.2015.04.010. Epub 2015 Apr 30.
Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes, and their elucidation at the systems level requires genome-wide data and biological networks. Genome-scale meta
PMID 25937284

Japanese Journal

レチノイン酸の代謝と機能にかかわる遺伝子多型 : ALDH1A2とRARβの場合(<特集>「ビタミンと遺伝子多型」-ビタミンA-)

四童子好廣
ビタミン 87(10), 551-556, 2013-10-25
… Few association studies on vitamin A and genetic polymorphism have been conducted so far, even though brilliant success has been achieved in translational researches on vitamin D receptor or methylene tetrahydrofolate reductase gene polymorphism. …
NAID 110009674992

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Kikuchi Goro,Motokawa Yutaro,Yoshida Tadashi [他],HIRAGA Koichi
Proceedings of the Japan Academy, Series B 84(7), 246-263, 2008
… + NADH + H<SUP>+</SUP>The glycine cleavage system is widely distributed in animals, plants and bacteria and consists of three intrinsic and one common components: those are i) P-protein, a pyridoxal phosphate-containing protein, ii) T-protein, a protein required for the tetrahydrofolate-dependent reaction, iii) H-protein, a protein that carries the aminomethyl intermediate and then hydrogen through the prosthetic lipoyl moiety, and iv) L-protein, a common lipoamide dehydrogenase. …
NAID 130000093931

Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa

IACOPETTA Barry,GRIEU Fabienne,PHILLIPS Michael,RUSZKIEWICZ Andrew,MOORE James,MINAMOTO Toshinari,KAWAKAMI Kazuyuki
Cancer science 98(9), 1454-1460, 2007-09-10
… The methylation level of LINE-1 repeats in normal colonic mucosa also showed significant associations with common polymorphisms in the methylene tetrahydrofolate reductase and methylene tetrahydrofolate dehydrogenase genes involved in methyl group metabolism. …
NAID 10019998960

★リンクテーブル★

リンク元	「ジヒドロ葉酸還元酵素」「テトラヒドロ葉酸脱水素酵素」「テトラヒドロ葉酸デヒドロゲナーゼ」
拡張検索	「methylenetetrahydrofolate dehydrogenase」「5,10-methylenetetrahydrofolate dehydrogenase」
関連記事	「dehydrogenase」「dehydrogenases」