テトラサイクリン系耐性肺炎球菌
WordNet
- impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion"
- respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants
- spherical Gram-positive bacteria occurring in pairs or chains; cause e.g. scarlet fever and tonsillitis (同)streptococci, strep
- an antibiotic (trade name Achromycin) derived from microorganisms of the genus Streptomyces and used broadly to treat infections (同)Achromycin
PrepTutorEJDIC
- 抵抗力のある;(…に)抵抗する《+『to』+『名』》
- 肺炎
- 連鎖球菌
UpToDate Contents
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English Journal
- Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.
- Lupien A1, Gingras H1, Leprohon P1, Ouellette M2.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 Jul 16. pii: dkv211. [Epub ahead of print]
- OBJECTIVES: Tigecycline is a broad-spectrum antibiotic acting at the level of the 30S ribosomal subunit to inhibit translation. While Streptococcus pneumoniae remains susceptible to tigecycline, resistance is beginning to emerge in some species and mainly involves efflux or mutations in ribosome con
- PMID 26183184
- Multidrug-Resistant Streptococcus pneumoniae Isolates from Healthy Ghanaian Preschool Children.
- Dayie NT1,2, Arhin RE1, Newman MJ1, Dalsgaard A2, Bisgaard M2, Frimodt-Møller N3, Slotved HC4.
- Microbial drug resistance (Larchmont, N.Y.).Microb Drug Resist.2015 Jul 14. [Epub ahead of print]
- Streptococcus pneumoniae is the cause of high mortality among children worldwide. Antimicrobial treatment and vaccination are used to control pneumococcal infections. In Ghana, data on antimicrobial resistance and the prevalence of multidrug-resistant pneumococcal clones are scarce; hence, the aim o
- PMID 26172078
- Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing.
- Lupien A1, Gingras H1, Bergeron MG1, Leprohon P1, Ouellette M2.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 Jul;70(7):1946-59. doi: 10.1093/jac/dkv060. Epub 2015 Apr 9.
- OBJECTIVES: The objective of this study was to characterize chromosomal mutations associated with resistance to tetracycline in Streptococcus pneumoniae.METHODS: Chronological appearance of mutations in two S. pneumoniae R6 mutants (R6M1TC-5 and R6M2TC-4) selected for resistance to tetracycline was
- PMID 25862682
Japanese Journal
- 多剤耐性肺炎球菌による呼吸器感染症および耳鼻咽喉科領域感染症に対する garenoxacin の臨床効果
- 河野 茂,小林 宏行,馬場 駿吉,高畑 正裕,Kohno Shigeru,Kobayashi Hiroyuki,Baba Shunkichi,Takahata Masahiro
- 日本化学療法学会雜誌 = Japanese journal of chemotherapy 55, 222-230, 2007-10-01
- … 新規な経口デスフルオロキノロン系抗菌薬であるgarenoxacin mesilate hydrate（GRNX）の呼吸器感染症および耳鼻咽喉科領域感染症を対象とした臨床試験（8試験）から，Streptococcus pneumoniaeを原因菌とする症例を対象として，原因菌の各種抗菌薬に対する感受性を測定し，多剤耐性肺炎球菌の同定，penicillin binding protein（PBP）遺伝子変異およびマクロライド耐性遺伝子の解析を行い，S. …
- NAID 10019948748
Related Links
- Sixty-five clinical isolates of Streptococcus pneumoniae, all collected in Italy between 1999 and 2002 and resistant to both tetracycline (MIC, ≥8 μg/ml) and erythromycin (MIC, ≥1 μg/ml), were investigated. Of these strains, 11% were ...
- ABSTRACT The aim of the present study was to examine the stability and evolution of tet(M)-mediated resistance to tetracyclines among members of different clonal lineages of Streptococcus pneumoniae. Thirty-two tetracycline ...
★リンクテーブル★
[★]
- 英
- tetracycline-resistant Streptococcus pneumoniae
[★]
- ラ
- Streptococcus pneumoniae
- 同
- 肺炎球菌、肺炎レンサ球菌、肺炎連鎖球菌、肺炎双球菌、ストレプトコッカス・ニューモニエ
- 関
- 連鎖球菌
- first aid step1 2006 p.134,138
細菌学
- グラム陽性球菌
- 西洋槍(ランセット)型の双球菌
- α溶血性。ランスフィールド分類には分類されない
- オプトヒン感受性
- 自己融解 autolysis ← 培養しすぎに注意
- 中心部の陥凹した集落
- 莢膜多糖体を有する ← 抗食菌作用(C3bの付着に抵抗する)
- IgA proteaseを分泌
- 健常人の5-250%の気道に存在するが莢膜がない弱毒の株
感染症
-
易感染性宿主
- 2歳以下の乳幼児や老人で重症化しやすい
- 脾臓を受けた患者、急性骨髄性白血病、骨髄移植、HIV感染症で発症しやすい
most common cause of:
MOPS are Most OPtochin Sensitive
診断
- 臨床像から疑い、胸部X線、喀痰のグラム染色、尿中抗原を行う。グラム染色と尿中抗原が陽性であれば特異的な治療を開始する。 (IRE.1010)
- (経験的治療の前に？)診断及び感受性検査のために喀痰培養、血液培養検査を行う。
参考
USMLE
[★]
- 関
- recalcitrance、refractory、resist、resistance、resistive、stand、tolerance、tolerant、withstand
[★]
Streptococcus pneumoniae、Klebsiella pneumoniae、Mycoplasma pneumoniae、Chlamydia pneumoniae、Chlamydophila pneumoniae
[★]
テトラサイクリン, TC
[★]
テトラサイクリン系抗菌薬