WordNet

a complex consisting of an organic base in association with hydrogen chloride
a crystalline compound used in the form of a hydrochloride as a local anesthetic

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Novel serine-based gemini surfactants as chemical permeation enhancers of local anesthetics: A comprehensive study on structure-activity relationships, molecular dynamics and dermal delivery.

Teixeira RS1, Cova TF2, Silva SM3, Oliveira R4, do Vale ML5, Marques EF6, Pais AA2, Veiga FJ7.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2015 Jun;93:205-13. doi: 10.1016/j.ejpb.2015.02.024. Epub 2015 Mar 6.
This work aims at studying the efficacy of a series of novel biocompatible, serine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine, combining an experimental and computational approach. The surfactants consist of gemini molecules str
PMID 25748796

Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics.

Teixeira RS1, Cova TF2, Silva SM2, Oliveira R3, Araújo MJ4, Marques EF4, Pais AA3, Veiga FJ5.
International journal of pharmaceutics.Int J Pharm.2014 Oct 20;474(1-2):212-22. doi: 10.1016/j.ijpharm.2014.08.002. Epub 2014 Aug 7.
The aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences
PMID 25108047

Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons.

Zhang L1, Tanabe K1, Yanagidate F1, Kawasaki Y2, Chen G1, Dohi S3, Iida H4.
European journal of pharmacology.Eur J Pharmacol.2014 Jul 5;734:132-6. doi: 10.1016/j.ejphar.2014.03.048. Epub 2014 Apr 12.
Local anesthetics, which are widely known to be neuronal voltage-gated Na(+) channel blockers, also affect a variety of other ion channels, N-methyl-d-asparate (NMDA) receptors and α-amino-3-hydroxy-5-methyl-4-izoxazolepropionic acid (AMPA) receptors. Glutamate, which is released from presynaptic f
PMID 24726558