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- 1. 卵巣胚細胞腫瘍：病理学、臨床症状、および診断 ovarian germ cell tumors pathology clinical manifestations and diagnosis
- 2. 縦隔および後腹膜を含む性腺外胚細胞腫瘍 extragonadal germ cell tumors involving the mediastinum and retroperitoneum
- 3. 頭蓋内胚細胞腫瘍 intracranial germ cell tumors
- 4. 仙尾骨部胚細胞腫瘍 sacrococcygeal germ cell tumors
- 5. 精巣腫瘍の解剖学および病理 anatomy and pathology of testicular tumors
- Non-genomic estrogen/estrogen receptor α promotes cellular malignancy of immature ovarian teratoma in vitro.
- Hung YC1, Chang WC, Chen LM, Chang YY, Wu LY, Chung WM, Lin TY, Chen LC, Ma WL.Author information 1Sex Hormone Research Center, Department of Obstetric and Gynecology, China Medical University Hospital, Taichung, Taiwan; Department of Pathology, China Medical University Hospital, Taichung, Taiwan; Graduate Institution of Clinical Medical Science, School of Medicine, China Medical University, Taichung, Taiwan.AbstractMalignant immature ovarian teratomas (IOTs) most often occur in women of reproductive age. It is unclear, however, what roles estrogenic signaling plays in the development of IOT. In this study, we examined whether estrogen receptors (ERα and β) promote the cellular malignancy of IOT. Estradiol (E2), PPT (propylpyrazole), and DPN (diarylpropionitrile) (ERα- and β-specific agonists, respectively), as well as ERα- or ERβ-specific short hairpin (sh)RNA were applied to PA-1 cells, a well-characterized IOT cell line. Cellular tumorigenic characteristics, for example, cell migration/invasion, expression of the cancer stem/progenitor cell marker CD133, and evidence for epithelial-mesenchymal transition (EMT) were examined. In PA-1 cells that expressed ERα and ERβ, we found that ERα promoted cell migration and invasion. We also found that E2/ERα signaling altered cell behavior through non-classical transactivation function. Our data show non-genomic E2/ERα activations of focal adhesion kinase-Ras homolog gene family member A (FAK-RhoA) and ERK governed cell mobility capacity. Moreover, E2/ERα signaling induces EMT and overexpression of CD133 through upregulation micro-RNA 21 (miR21; IOT stem/progenitor promoter), and ERK phosphorylations. Furthermore, E2/ERα signaling triggers a positive feedback regulatory loop within miR21 and ERK. At last, expression levels of ERα, CD133, and EMT markers in IOT tissue samples were examined by immunohistochemistry. We found that cytosolic ERα was co-expressed with CD133 and mesenchymal cell markers but not epithelial cell markers. In conclusion, estrogenic signals exert malignant transformation capacity of cancer cells, exclusively through non-genomic regulation in female germ cell tumors.
- Journal of cellular physiology.J Cell Physiol.2014 Jun;229(6):752-61. doi: 10.1002/jcp.24495.
- Malignant immature ovarian teratomas (IOTs) most often occur in women of reproductive age. It is unclear, however, what roles estrogenic signaling plays in the development of IOT. In this study, we examined whether estrogen receptors (ERα and β) promote the cellular malignancy of IOT. Estradiol (E
- PMID 24142535
- Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.
- Kao CS1, Ulbright TM, Young RH, Idrees MT.Author information 1*Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN †The James Homer Wright Pathology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA.AbstractA total of 180 consecutive testicular cancers containing a component of embryonal carcinoma (EC) were reviewed to assess the morphologic features of the EC component. EC mostly (84%) occurred as a component of a mixed germ cell tumor, but 16% were pure. Solid (55%), glandular (17%), and papillary (11%) were the most common primary patterns (predominant architectural pattern occupying at least 50%), whereas other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%). Occasionally, EC developed predominantly in the context of polyembryoma-like (6%) and diffuse embryoma-like ("necklace" pattern) (3%) proliferations. In all, 69% had secondary architectural patterns, the most frequent being glandular (31%), papillary (14%), and solid (12%). An appliqué appearance, in which smudged and degenerate-appearing EC cells appear "applied" to the tumor periphery, was common (67%). EC cells with clear cytoplasm and distinct cell membranes (seminoma-like) were present in 11%, and dense lymphocytic infiltration and granulomatous inflammation were seen in 7% and 3%, respectively. Features simulating yolk sac tumor and teratoma were also seen: pseudoendodermal sinuses (34%), columnar cells (20%), and secretory-type subnuclear cytoplasmic vacuoles (6%). Syncytiotrophoblast cells were frequent (46%). Intratubular EC, typically partly necrotic and calcified, occurred in 24%. The associated stroma was more often non-neoplastic (53%) than neoplastic (29%). The rarity of some poorly characterized patterns of EC (micropapillary, blastocyst-like, anastomosing glandular, and sieve-like glandular) and some that overlap with those of other germ cell tumors, as well as some uncommon cytologic features, may result in misinterpretation, potentially impacting management. The association with other more common patterns and typical cytologic features, together with simple awareness of these variant morphologies, are helpful in establishing an accurate diagnosis of EC.
- The American journal of surgical pathology.Am J Surg Pathol.2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171.
- A total of 180 consecutive testicular cancers containing a component of embryonal carcinoma (EC) were reviewed to assess the morphologic features of the EC component. EC mostly (84%) occurred as a component of a mixed germ cell tumor, but 16% were pure. Solid (55%), glandular (17%), and papillary (1
- PMID 24503753
- Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma
- TAKAHASHI Nozomi,YAMAGUCHI Eito,KAWABATA Yukiko,KONO Tomohiro
- Journal of Reproduction and Development, 2014
- … To determine the role of ncRNAs in tumorigenesis, we induced teratomas by engrafting E6.5 embryos (wildtype or Gtl2(–/+)) under the kidney capsule of scid mice. … Some teratomas derived from the Gtl2(–/+) embryos exhibited hypertrophic growth, suggesting that ncRNAs, including Gtl2, may act as tumor suppressors in vivo. …
- NAID 130004701540
- Influence of MWCNTs to Myocardial Contraction Rhythms on Differentiation of ES-D3 Cells in Three-dimensional Culture
- IMAI Koichi,SHIRAI Tsubasa,WATARI Fumio,AKASAKA Tsukasa,NISHIKAWA Tetsunari,OKAMURA Tomoharu,TANAKA Akio,SUESE Kazuhiko,OGAWA Fumiya,HONDA Yoshitomo,SAWAI Hirofumi,TAKASHIMA Hiromasa
- Nano Biomedicine 6(1), 27-34, 2014
- … The contraction of myocardia that differentiated in teratomas could be microscopically observed. … Some teratomas showed peristalsis, suggesting differentiation into the gastrointestinal tract. …
- NAID 130004679867