tenoxicam

Tenoxicam
Systematic (IUPAC) name
	(3E)-3-[hydroxy(pyridin-2-ylamino)methylene] -2-methyl-2,3-dihydro-4H-thieno[2,3-e] [1,2]thiazin-4-one 1,1-dioxide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	Prescription Only (S4) (AU) POM (UK)
Routes	Oral
Pharmacokinetic data
Protein binding	High
Half-life	30–140 hours
Identifiers
CAS number
ATC code	M01AC02
PubChem	CID 5282194
ChemSpider	4471584
UNII	Z1R9N0A399
KEGG	D01767
ChEBI	CHEBI:32192
Chemical data
Formula	C13H11N3O4S2
Mol. mass	337.376 g/mol
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テノキシカム

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/04 13:47:32」(JST)

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Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID). It is manufactured by Roche under the trade name Mobiflex. It is available in the United Kingdom as a prescription-only drug. Tenoxicam belongs to the class of NSAIDs known as oxicams. It is used to relieve inflammation, swelling, stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a type of arthritis involving the spine), tendinitis (inflammation of a tendon), bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and periarthritis of the shoulders or hips (inflammation of tissues surrounding these joints).

Contraindications

The drug is contraindicated for patients who are seniors who have been given anesthesia or surgery; are at risk of increased bleeding or kidney failure; have an active inflammatory disease involving the stomach or intestine (like ulcerative colitis); have an active stomach or intestinal ulcer; have had an acute asthmatic attack, hives, rhinitis (inflammation of the inner lining of the nasal passage), or other allergic reactions caused by Aspirin or other nonsteroidal anti-inflammatory drugs (for example diclofenac, ibuprofen, indomethacin, naproxen).

References

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UpToDate Contents

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English Journal

Cyclooxygenase inhibitors reduce biofilm formation and yeast-hypha conversion of fluconazole resistant Candida albicans.

Abdelmegeed E, Shaaban MI.SourceMicrobiology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia, 35516, Egypt.
Journal of microbiology (Seoul, Korea).J Microbiol.2013 Sep 14. [Epub ahead of print]
The incidence of fluconazole-resistant Candida albicans has been increasing worldwide. Both biofilm and fungal morphogenesis are main virulence factors of C. albicans cells. Extracellular fungal prostaglandins are synthesized during biofilm adhesion and development and through yeast-hypha conversion
PMID 24037655

The next step in the treatment of persistent temporomandibular joint pain following arthrocentesis: A retrospective study of 18 cases.

Emes Y, Arpınar IS, Oncü B, Aybar B, Aktaş I, Al Badri N, Atalay B, Işsever H, Yalçın S.SourceDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. Electronic address: yusufemes@yahoo.com.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.J Craniomaxillofac Surg.2013 Aug 6. pii: S1010-5182(13)00183-2. doi: 10.1016/j.jcms.2013.06.010. [Epub ahead of print]
Temporomandibular joint disorders affect a big portion of the population. There are a variety of treatment methods currently in use. Conservative treatment modalities are followed by more invasive approaches like arthrocentesis or arthroscopy. The aim of the study is to compare the effects of intra-
PMID 23932198

Computational nanochemistry report on the oxicams--conceptual DFT indices and chemical reactivity.

Martínez-Araya JI, Salgado-Morán G, Glossman-Mitnik D.SourceDirección de Investigación y Desarrollo, Universidad Pedro de Valdivia, Sede Santiago, Campus Tobalaba, Santiago, Chile.
The journal of physical chemistry. B.J Phys Chem B.2013 May 30;117(21):6339-51. doi: 10.1021/jp400241q. Epub 2013 May 20.
A density functional theory study of eight oxicams was carried out in order to determine their global and local reactivities. These types of reactivities were measured by means of global and local reactivity descriptors coming from the conceptual density functional theory. Net electrophilicity as a
PMID 23656309

Japanese Journal

Effectiveness of tenoxicam and ibuprofen for pain prevention following endodontic therapy in comparison to placebo: a randomized double-blind clinical trial

Arslan Hakan,Topcuoglu Huseyin S.,Aladag Halit
Journal of Oral Science 53(2), 157-161, 2011
… Tenoxicam is an effective analgesic and anti-inflammatory agent for symptomatic treatment of various conditions. … The purpose of this study was to evaluate clinically the effectiveness of prophylactic tenoxicam and prophylactic ibuprofen in reducing post-endodontic pain compared with placebo. … A total of 48 patients consented to a double-blind, single dose, prophylactic oral administration of 20 mg of tenoxicam, 200 mg of ibuprofen, or a placebo before root canal treatment. …
NAID 130000834354

Indirect Flow-Injection Spectrophotometric Determination of Meloxicam, Tenoxicam and Piroxicam in Pharmaceutical Formulations

Al-Momani Idrees F.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 22(12), 1611-1614, 2006-12-10
NAID 10020140476

Spectrofluorimetric and Spectrophotometric Stability-Indicating Methods for Determination of Some Oxicams Using 7-Chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD-Cl)

Taha Elham Anwer,Salama Nahla Nour,Fattah Laila El-Sayed Adbel
Chemical & pharmaceutical bulletin 54(5), 653-658, 2006-05-01
… Two sensitive and selective spectrofluorimetric and spectrophotometric stability-indicating methods have been developed for the determination of some non-steroidal anti-inflammatoy oxicam derivatives namely lornoxicam (Lx), tenoxicam (Tx) and meloxicam (Mx) after their complete alkaline hydrolysis. …
NAID 110004836346

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