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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/09 09:12:28」(JST)

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  • Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.
  • Dai C, Zhang B, Liu X, Guo K, Ma S, Cai F, Yang Y, Yao Y, Feng M, Bao X, Deng K, Jiao Y, Wei Z, Junji W, Xing B, Lian W, Wang R.SourceDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Oct 15;133(8):1982-93. doi: 10.1002/ijc.28199. Epub 2013 Jun 13.
  • Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metast
  • PMID 23564480
  • Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma.
  • Raciborska A, Bilska K, Drabko K, Chaber R, Pogorzala M, Wyrobek E, Polczyńska K, Rogowska E, Rodriguez-Galindo C, Wozniak W.SourceDepartment of Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland.
  • Pediatric blood & cancer.Pediatr Blood Cancer.2013 Oct;60(10):1621-5. doi: 10.1002/pbc.24621. Epub 2013 Jun 15.
  • BACKGROUND: Patients with metastatic, progressive or recurrent Ewing sarcoma (ES) have a dismal outcome. The combination of irinotecan and temozolomide has been proposed as an effective salvage regimen for some pediatric malignancies. Thus, we sought to evaluate this combination with vincristine for
  • PMID 23776128
  • Stability of sample solution as a crucial point during HPLC determination of chemical purity of temozolomide drug substance.
  • Jedynak Ł, Puchalska M, Zezula M, Łaszcz M, Łuniewski W, Zagrodzka J.SourcePharmaceutical Research Institute, R&D Analytical Chemistry Department, Rydygiera 8, 01-793 Warsaw, Poland. l.jedynak@ifarm.eu
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Sep;83:19-27. doi: 10.1016/j.jpba.2013.04.032. Epub 2013 Apr 30.
  • An HPLC method for determination of related substances in temozolomide drug substance was developed. Particular attention was paid to the stability studies due to the fact that temozolomide is unstable in a solution and quickly decomposes to its main degradation product 5-amino-4-imidazolecarboxamid
  • PMID 23702563


  • Dose-dense Temozolomide: Is It Still Promising?
  • Neurologia medico-chirurgica 55(1), 38-49, 2015
  • … Glioblastoma (GBM) has proven to be incurable despite recent progress on its standard of care using temozolomide (TMZ) as the main trunk of initial therapy for newly diagnosed GBM. …
  • NAID 130004922271
  • Inhibition of ABCG2 enhances chemo-sensitivity of murine glioma stem cell-like cells to temozolomide and reduces spheroid-forming capability
  • Yoshioka Hiromasa,Okuda Takeshi,Fujita Mitsugu,Inoue Takao,Tasaki Takayuki,Izumoto Shuichi,Kato Amami
  • ACTA MEDICA 39(2), 105-113, 2014-12
  • … As a consequence, we show that siRNA-mediated ABCG2 inhibition enhances the sensitivity of GSC_S to temozolomide (TMZ) and in turn reduces their spheroid-forming capability. …
  • NAID 120005539589
  • Interferon-β inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein 10
  • Takano Shingo,Ishikawa Eiichi,Matsuda Masahide,Yamamoto Tetsuya,Matsumura Akira
  • International journal of oncology 45(5), 1837-1846, 2014-11
  • … Recently IFN-β is re-evaluated for its sensitization mechanism to the chemotherapeutic agent temozolomide, because angiogenesis is essential for malignant glioma growth. …
  • NAID 120005496691


^ a b c Temodar label Last updated Feb 2011 ^ a b NICE NICE technology appraisal guidance [TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)] Published date: April 200 ^ Sitbon Sitruk, L.; Sanson, M.; Prades, M.; Lefebvre, G.; Schubert, B.; Poirot, C. (2010).
Temozolomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea vomiting diarrhea constipation loss of appetite sores in the mouth and throat headache pale skin


Temozolomide-3D-spacefill.pngDescription Temozolomide structure.png temozolomide resistance in glioblastomaTemozolomide - Struttura ChimicaPHAR rx-tasgt Study Guide (2013-14  preparing temozolomide - Google Patents




  • 2005年テモゾロミドと放射線治療との併用療法が世界的に標準治療となった。
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