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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
3. クリンダマイシン：概要 clindamycin an overview
4. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
5. 慢性非アレルギー性鼻炎 chronic nonallergic rhinitis

Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.

Ohnishi K1, Murase M, Nakano D, Pelisch N, Hitomi H, Kobori H, Morimoto S, Mori H, Masaki T, Ohmori K, Kohno M, Ichihara A, Nishiyama A.
Journal of pharmacological sciences.J Pharmacol Sci.2013;122(2):103-8. Epub 2013 May 22.
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor-dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor blocker, olmesartan, prevented elevation of Ang
PMID 23698111

Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport.

Yamamoto D1, Takai S, Akimoto T, Hirahara I, Ito C, Muto S, Kusano E.
Clinical and experimental pharmacology & physiology.Clin Exp Pharmacol Physiol.2012 Oct;39(10):864-8. doi: 10.1111/j.1440-1681.2012.12003.x.
1. Matrix metalloproteinase (MMP)-2 plays an important role in tissue remodelling during peritoneal injury caused by peritoneal dialysis (PD), but MMP-2 inhibitors have not yet been used clinically. Recently, it was reported that captopril, an angiotensin-converting enzyme inhibitor (ACEI), can inhi
PMID 23013132

Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case.

Ohura K1, Nozawa T, Murakami K, Imai T.
Journal of pharmaceutical sciences.J Pharm Sci.2011 Sep;100(9):3985-94. doi: 10.1002/jps.22628. Epub 2011 May 26.
The intestinal absorption mechanism of temocapril, an ester-type prodrug of temocaprilat, was evaluated using Caco-2 cell monolayers with or without active carboxylesterase (CES)-mediated hydrolysis. The inhibition of CES-mediated hydrolysis was achieved by pretreatment of the monolayers with bis-p-
PMID 21618543

In Half of Hypertensive Diabetics, Co-Administration of a Calcium Channel Blocker and an Angiotensin-Converting Enzyme Inhibitor Achieved a Target Blood Pressure of<130/80mmHg : The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes (ATTEST) Study

KATAYAMA Shigehiro,KAWAMORI Ryuzo,IWAMOTO Yasuhiko,SAITO Ikuo,KURAMOTO Kizuku
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 31(8), 1499-1508, 2008-08-01
NAID 10024361395