tegaserod maleate

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/30 21:44:47」(JST)

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  • An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954.
  • Beattie DT, Higgins DL, Ero MP, Amagasu SM, Vickery RG, Kersey K, Hopkins A, Smith JA.SourceTheravance, Inc., 901 Gateway Boulevard, South San Francisco, CA 94080, USA. Electronic address: dbeattie@theravance.com.
  • Vascular pharmacology.Vascul Pharmacol.2013 Jan;58(1-2):150-6. doi: 10.1016/j.vph.2012.11.002. Epub 2012 Nov 29.
  • The 5-HT(4) receptor agonists, and gastrointestinal (GI) prokinetic agents, cisapride and tegaserod, lack selectivity for the 5-HT(4) receptor. Cisapride is a potent human ether-à-go-go-related gene (hERG) potassium channel inhibitor while cisapride and tegaserod have significant affinity for 5-HT(
  • PMID 23201772
  • The Zelnorm epidemiologic study (ZEST): a cohort study evaluating incidence of abdominal and pelvic surgery related to tegaserod treatment.
  • Seeger JD, Quinn S, Earnest DL, Lembo A, Kuo B, Rivero E, Walker AM.SourceBrigham & Women's Hospital and Harvard Medical School, Boston, MA, USA. jdseeger@partners.org.
  • BMC gastroenterology.BMC Gastroenterol.2012 Nov 30;12:171. doi: 10.1186/1471-230X-12-171.
  • ABSTRACT:BACKGROUND: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of abdominal or pelvic surgery, including cholecystectomy.METHODS: This coho
  • PMID 23198861
  • Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats.
  • Yan C, Xin-Guang L, Hua-Hong W, Jun-Xia L, Yi-Xuan L.SourceDepartment of Gastroenterology, Peking University First Hospital, Beijing, China.
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.].Braz J Med Biol Res.2012 Oct;45(10):948-54. Epub 2012 Jul 26.
  • Visceral hypersensitivity plays an important role in motor and sensory abnormalities associated with irritable bowel syndrome, but the underlying mechanisms are not fully understood. The present study was designed to evaluate the expression of the 5-HT(4) receptor and the serotonin transporter (SERT
  • PMID 22832600


  • Tegaserod maleate in the treatment of irritable bowel syndrome : a clinical review


View and buy high purity Tegaserod maleate from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... References Buchheit et al (1995) The serotonin 5-HT 4 receptor. 2. Structure-activity ...
Buy Tegaserod maleate (CAS 189188-57-6), a SR-4 partial agonist, from Santa Cruz. Purity: ≥97%, Molecular Formula: C20H27N5O5, MW: 417.46 ... For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.


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maleic acid

WordNet   license wordnet

「a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation」