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  • Luminal 5-HT stimulates colonic bicarbonate secretion in rats.
  • Kaji I1,2, Akiba Y1,2,3, Said H4, Narimatsu K1, Kaunitz JD1,5,2,3.
  • British journal of pharmacology.Br J Pharmacol.2015 Oct;172(19):4655-70. doi: 10.1111/bph.13216. Epub 2015 Aug 26.
  • BACKGROUND AND PURPOSE: The bioactive monoamine 5-HT, implicated in the pathogenesis of functional gastrointestinal disorders, is abundantly synthesized and stored in rat proximal colonic mucosa and released to the gut lumen and subepithelial space. Despite much data regarding its expression and fun
  • PMID 26061462
  • Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.
  • Han X1,2,3, Quinney SK2,4,5, Wang Z2,6, Zhang P2, Duke J7, Desta Z3,5, Elmendorf JS8, Flockhart DA3,5, Li L2,3,6,7.
  • Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2015 Sep;98(3):321-7. doi: 10.1002/cpt.150.
  • Myopathy is a group of muscle diseases that can be induced or exacerbated by drug-drug interactions (DDIs). We sought to identify clinically important myopathic DDIs and elucidate their underlying mechanisms. Five DDIs were found to increase the risk of myopathy based on analysis of observational da
  • PMID 25975815
  • A high-throughput method for predicting drug effects on gut transit time using larval zebrafish.
  • Cassar S1, Huang X2, Cole T2.
  • Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2015 Aug 24;76:72-75. doi: 10.1016/j.vascn.2015.08.156. [Epub ahead of print]
  • INTRODUCTION: Zebrafish are an attractive vertebrate model due to their small size, transparency through organogenesis, and high fecundity. The zebrafish gastrointestinal (GI) tract is similar to the mammalian GI tract in gene expression, nervous system control, and response to chemical challenges.
  • PMID 26311656


  • 排便と健康
  • 浦尾 正彦
  • 順天堂醫事雑誌 60(1), 16-24, 2014
  • 便秘とは,排便の頻度が週2回以下で,便が硬く,排便困難,残便感がある状態といわれている.実際には放置されていたり自己流の対処をされていることが多い.が,便秘患者では労働生産性が障害されたり,肛門疾患や結腸癌などの様々なリスクも増加することが知られており,しっかり取り組むべき疾患である.慢性便秘は,症候性,薬剤性,器質性,機能性便秘などに分類される.症候性便秘は神経疾患,内分泌疾患の症状の一部として …
  • NAID 130004684311
  • Contribution of Active and Inactive States of the Human 5-HT_<4d> Receptor to the Functional Activities of 5-HT_4-Receptor Agonists
  • Mikami Tadayoshi,Sugimoto Hiromi,Naganeo Rie [他],OHMI Takashi,SAITO Toshiyuki,EDA Hiroyuki
  • Journal of pharmacological sciences 107(3), 251-259, 2008-07-20
  • … In competitive binding assays, full agonists such as 5-methoxytryptamine and tegaserod showed 2- to 8-fold higher affinities for [3H]5-HT binding (KH) than for [3H]GR113,808 binding (KL) (KH<KL). …
  • NAID 10024321238
  • Determination of tegaserod by LC-ESI-MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers
  • ZOU Jian-Jun,BIAN Xiao-Jie,DING Li,ZHU Yu-Bin,FAN Hong-Wei,XIAO Da-Wei
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 861(1), 151-157, 2008-01-01
  • NAID 10024541695


Tegaserod. 15 likes · 0 talking about this. Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation. Approved by the FDA ...
In 2007, tegaserod was removed from the U.S. market and was made available only through a restricted distribution program from the manufacturer. Beginning in April 2008, tegaserod will no longer be available through the restricted ...



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