English Journal

Igarashi A1, Iijima H, Tamura G, Shirato K.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.1998 May;157(5 Pt 1):1531-5.
We studied the inhibitory effect of tazanolast, a selective mast-cell-stabilizing drug, on ozone-induced airway hyperresponsiveness in guinea pigs. Airway responsiveness to methacholine peaked at 2 h after ozone exposure (2.0 ppm for 2 h) and the number of neutrophils in bronchoalveolar lavage (BAL)
PMID 9603134

Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.

Kamei C1, Mio M, Yoshida T, Saito Y, Toyoda Y, Tsuriya Y.
Arzneimittel-Forschung.Arzneimittelforschung.1997 Apr;47(4):390-4.
WP-871 (3'-(1H-tetrazol-5-yl)oxanilic acid monohydrate, CAS 114607-46-4) is a monohydrate of a main active metabolite of tazanolast (butyl 3'-(1H-tetrazol-5-yl) oxanilate, CAS 82989-25-1), an orally active antiallergic drug. WP-871 inhibited dose-dependently compound 48/80-induced histamine release
PMID 9150859

Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract.

Tominaga T1, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H.
General pharmacology.Gen Pharmacol.1997 Mar;28(3):411-4.
1. The present study was carried out to investigate the effect of 3,5-bis-(acetoxyacetylamino)-4-chloro-benzonitrile (TYB-2285) on the accumulation of eosinophils in the peritoneal cavity of Wistar rats sensitized with Ascaris suum extract (Asc). 2. Rats were sensitized by IP injection of Asc on day
PMID 9068982

Japanese Journal

加納礼子,福石信之,交久瀬善隆,吉田隆志,波多野力,伊東秀之,赤木正明
日本薬理学雑誌 106, 207-211, 1995-09-01
… On the other hand, DSCG, repirinast, ibudilast and tazanolast had no effect. …
NAID 10008631477