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  • Infrared and Raman spectroscopic methods for characterization of Taxus baccata L. - Improved taxane isolation by accelerated quality control and process surveillance.
  • Gudi G1, Krähmer A2, Koudous I3, Strube J4, Schulz H5.
  • Talanta.Talanta.2015 Oct 1;143:42-9. doi: 10.1016/j.talanta.2015.04.090. Epub 2015 May 8.
  • Different yew species contain poisonous taxane alkaloids which serve as resources for semi-synthesis of anticancer drugs. The highly variable amounts of taxanes demand new methods for fast characterization of the raw plant material and the isolation of the target structures during phyto extraction.
  • PMID 26078126
  • A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
  • Ohira M1, Iwasaki Y1, Tanaka C1, Kuroki M1, Matsuo N1, Kitamura T1, Yukuhiro M1, Morimoto H2, Pang N2, Liu B2, Kiyono T3, Amemiya M4, Tanaka K5, Yoshida K1, Sugimoto N1, Ohshima T6, Fujita M7.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1850(9):1676-84. doi: 10.1016/j.bbagen.2015.04.013. Epub 2015 May 7.
  • BACKGROUND: The mitotic spindles are among the most successful targets of anti-cancer chemotherapy, and they still hold promise as targets for novel drugs. The anti-mitotic drugs in current clinical use, including taxanes, epothilones, vinca alkaloids, and halichondrins, are all microtubule-targetin
  • PMID 25960391
  • Impact of tumor angiogenic profile on the outcome of patients with metastatic breast carcinoma treated with weekly docetaxel. A Hellenic Cooperative Oncology Group (HeCOG) study.
  • Kourea HP1, Kotoula V2, Koutras A3, Alexopoulou Z4, Papaspirou I5, Skarlos DV6, Efstratiou I7, Bobos M8, Zagouri F9, Papakostas P10, Pectasides D11, Chrisafi S8, Varthalitis I12, Aravantinos G13, Kosmidis P14, Bafaloukos D15, Scopa CD16, Fountzilas G17.
  • Histology and histopathology.Histol Histopathol.2015 Sep;30(9):1129-41. doi: 10.14670/HH-11-612. Epub 2015 Mar 25.
  • BACKGROUND: Metronomic taxane administration has putative antiangiogenic properties. Herein, we examined the baseline tumor angiogenic profile of patients with metastatic breast carcinoma (MBC) in a prospective-retrospective translational research study. The interplay between the angiogenic factors
  • PMID 25807307


  • ^<18>F-Fluorodeoxyglucose positron emission tomography optimizes neoadjuvant chemotherapy for primary breast cancer to achieve pathological complete response
  • UEDA Shigeto,SAEKI Toshiaki,SHIGEKAWA Takashi,OMATA Jiro,MORIYA Tomoyuki,YAMAMOTO Junji,OSAKI Akihiko,FUJIUCHI Nobuko,MISUMI Misono,TAKEUCHI Hideki,SAKURAI Takaki,TSUDA Hitoshi,TAMURA Katsumi,ISHIDA Jiro,ABE Yoshiyuki,IMABAYASHI Etsuko,KUJI Ichiei,MATSUDA Hiroshi
  • International journal of clinical oncology 17(3), 276-282, 2012-06-01
  • NAID 10030951681
  • A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study.
  • Yamaguchi Hiroaki,Fujikawa Asuka,Ito Hajime,Tanaka Nobuaki,Furugen Ayako,Miyamori Kazuaki,Takahashi Natsuko,Ogura Jiro,Kobayashi Masaki,Yamada Takehiro,Mano Nariyasu,Iseki Ken
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 893-894, 157-161, 2012-04-15
  • … Docetaxel is a taxane family antineoplastic agent widely employed in cancer chemotherapy. …
  • NAID 120004856992
  • Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity
  • HIDAKA Masafumi,KOGA Tomoe,KIYOTA Hiromasa,HORIGUCHI Tohru,SHI Qing-Wen,HIROSE Keiko,UCHIDA Takafumi
  • Bioscience, biotechnology, and biochemistry 76(2), 349-352, 2012-02-23
  • … The structure of paclitaxel is composed of two key elements, a taxane ring and an <I>N</I>-benzoylphenylisoserine side chain at C-13. … A number of natural and artificial compounds with taxane skeletons have been isolated, but almost none of their bioactivities have been evaluated. … In this study, we focused on compounds having a taxane skeleton structure and examined their effects on tubulin dynamics. …
  • NAID 10030400057


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July 1, 2011 /PRNewswire/ -- ChromaDex Corporation (OTCBB: CDXC), a world leader in phytochemical reference standards and contract research, announces the addition of the Cedarburg Hauser Pharmaceuticals line of taxane and ...






  • イチイ樹皮から得られる生理活性成分;抗癌作用








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