関: sodium taurocholate、taurocholate

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/07 13:53:04」(JST)

wiki en

Taurocholic acid, known also as cholaic acid, cholyltaurine, or acidum cholatauricum, is a deliquescent yellowish crystalline bile acid involved in the emulsification of fats. It occurs as a sodium salt in the bile of mammals. It is a conjugate of cholic acid with taurine. In medical use, it is administered as a cholagogue and choleretic.

Hydrolysis of taurocholic acid yields taurine.

For commercial use, taurocholic acid is manufactured from cattle bile, a byproduct of the meat-processing industry.^[1]

This acid is also one of the many molecules in the body that has cholesterol as its precursor.

§Toxicity

LD50 in newborn rats is 380 mg/kg.

§See also

Deoxycholic acid

§References

^ Taurocholic acid, sodium salt at GlycoFineChem.com

UpToDate Contents

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English Journal

Optimization of extraction efficiency by shear emulsifying assisted enzymatic hydrolysis and functional properties of dietary fiber from deoiled cumin (Cuminum cyminum L.).

Ma M1, Mu T2, Sun H1, Zhang M1, Chen J1, Yan Z3.
Food chemistry.Food Chem.2015 Jul 15;179:270-7. doi: 10.1016/j.foodchem.2015.01.136. Epub 2015 Feb 7.
This study evaluated the optimal conditions for extracting dietary fiber (DF) from deoiled cumin by shear emulsifying assisted enzymatic hydrolysis (SEAEH) using the response surface methodology. Fat adsorption capacity (FAC), glucose adsorption capacity (GAC), and bile acid retardation index (BRI)
PMID 25722165

Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury.

Yang K1, Pfeifer ND2, Kock K2, Brouwer KL3.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Feb 23. pii: jpet.114.221564. [Epub ahead of print]
The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CLBile) vs. basolateral efflux (CLBL) clearance to hepatocellular bile acid excre
PMID 25711339

NTCP deficiency: A new inherited disease of bile acid transport.

Erlinger S1.
Clinics and research in hepatology and gastroenterology.Clin Res Hepatol Gastroenterol.2015 Feb;39(1):7-8. doi: 10.1016/j.clinre.2014.07.011. Epub 2014 Sep 2.
The authors report the case of a child with extreme elevation of serum bile acid concentration, without pruritus, symptomatic cholestasis, liver disease, or abnormalities of liver function tests. Sequencing of the SLC10A1 gene, encoding NTCP (the sinusoidal uptake transporter of conjugated bile acid
PMID 25193235

Japanese Journal

P-019 代謝活性化系in vitro遺伝毒性試験における媒体としてのタウロコール酸(ポスターセッション)

武下健次,山本祥太,野口幸弘
日本環境変異原学会大会プログラム・要旨集 (42), 84, 2013-10-30
NAID 110009732432

HepaRG®細胞を用いた薬物誘発性胆汁酸依存的肝毒性の評価系の確立

薄田健史,関根秀一,荻村栄一郎,橋元希美,伊藤晃成,堀江利治
日本毒性学会学術年会 40.1(0), 150627, 2013
… 同時に、Taurocholic acidの3H標識体を用いて、Biliary Excretion Index(BEI)法により、薬物のBSEP阻害能を評価した。 …
NAID 130004676647

Measurement of Bile Salt Export Pump Transport Activities using a Fluorescent Bile Acid Derivative

YAMAGUCHI Kana,MURAI Tsuyoshi,YABUUCHI Hikaru,HUI Shu-Ping,KUROSAWA Takao
Drug metabolism and pharmacokinetics 25(2), 214-219, 2010-04-25
… A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11). … The transport properties of the synthetic fluorescent bile acid derivative in membrane vesicles obtained from hBSEP-expressing Sf9 cells were examined using the liquid chromatography-electrospray ionization-mass spectrometry method. …
NAID 10027582678

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リンク元	「タウロコール酸」「taurocholate」「sodium taurocholate」

「タウロコール酸」

Taurocholic acid
Names
	IUPAC name 2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid
Identifiers
CAS Registry Number	81-24-3
ChEBI	CHEBI:28865
ChEMBL	ChEMBL224867
ChemSpider	6423
	InChI InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 ; Key: WBWWGRHZICKQGZ-HZAMXZRMSA-N ; InChI=1/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1; Key: WBWWGRHZICKQGZ-HZAMXZRMBW ;
Jmol-3D images	Image
PubChem	6675
	SMILES C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C ;
Properties
Molecular formula	C26H45NO7S
Molar mass	515.70 g·mol−1
Melting point	125.0 °C (257.0 °F; 398.1 K)
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references