WordNet
- a poisonous colorless salt used as a mordant and in medicine (同)antimony_potassium_tartrate
- a pastry cup with a filling of fruit or custard and no top crust
- a small open pie with a fruit filling
- an incrustation that forms on the teeth and gums (同)calculus, tophus
- a medicine that induces nausea and vomiting (同)vomit, vomitive, nauseant
PrepTutorEJDIC
- (味が)ぴりっとした,すっぱい / (気質・表現など)しんらつな,厳しい;(返事など)つっけんどんな
- 〈C〉タート,タルト(果物・カスタードなどの入った小さなパイ) / 〈C〉〈U〉《英》果物入りのパイ
- 酒石(ぶどう酒が発酵する時にたるの内側に沈殿する) / 歯石
- 催吐剤 / 吐き気を催させる,催吐性の
- 〈C〉(中世の/タタール)ダッタン)族[の人] / 〈C〉(その子孫である現在の)タタール人;タタール語 / 〈C〉《tartar》乱暴で手に負えない人
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/10 08:43:13」(JST)
[Wiki en表示]
Antimony potassium tartrate trihydrate |
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Other names
potassium antimonyl tartrate
emetic tartar
tartar emetic
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Identifiers |
CAS number |
28300-74-5 |
PubChem |
16682736 |
ChemSpider |
17214979 |
EC number |
234-293-3 |
KEGG |
C11340 |
ChEBI |
CHEBI:2761 |
Jmol-3D images |
Image 1 |
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[K+].[K+].[H]O[H].[H]O[H].[H]O[H].O=C1O[Sb-]23OC1C1O[Sb-]4(OC(C(O2)C(=O)O3)C(=O)O4)OC1=O
|
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InChI=1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
Key: WBTCZEPSIIFINA-UHFFFAOYSA-J
|
Properties |
Molecular formula |
K2Sb2(C4H2O6)2 · 3 H2O |
Molar mass |
667.87 g/mol |
Appearance |
white crystalline powder |
Density |
2.6 g/cm3 |
Solubility in water |
8.3 g/100 mL (0 °C)
35.9 g/100 mL (100 °C) |
Hazards |
EU classification |
Xn N |
R-phrases |
R20/22 R51/53 |
S-phrases |
(S2) S61 |
LD50 |
110 mg/kg |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Antimony potassium tartrate, also known as potassium antimonyl tartrate or emetic tartar has the formula K2Sb2(C4H2O6)2 is the double salt of potassium and antimony of tartaric acid. The compound has long been known as a powerful emetic. Besides, the compound was used in the treatment of schistosomiasis and leishmaniasis.
Contents
- 1 Emetic
- 2 Medical
- 3 Preparation
- 4 References
- 5 Further reading
|
Emetic [edit]
Antimony potassium tartrate's potential as an emetic was known since the Middle Ages. The compound itself was considered toxic and therefore a different way to administer it was found. Cups made from pure antimony were used to store wine for 24 hours and then the resulting solution of antimony potassium tartrate in wine was consumed in small portions until the wanted emetic effect was reached.[1][2][3]
Today the compound is still used to induce vomiting in captured animals to study their diet.[4][5][6]
Medical [edit]
The first treatment application against trypanosomiasis was tested in 1906, and the compound's use to treat other tropical diseases was researched.[7] The treatment of leishmania with antimony potassium tartrate started in 1913. After the introduction of antimony (V) containing complexes like sodium stibogluconate and meglumine antimoniate, the use of antimony potassium tartrate was phased out.[7][8] After British physician John Brian Christopherson's discovery in 1918 that antimony potassium tartrate could cure schistosomiasis, the antimonial drugs became widely used.[9][10][11] However, the injection of antimony potassium tartrate had severe side effects such as Adams–Stokes syndrome[12] and therefore alternative substances were under investigation. With the introduction and subsequent larger use of praziquantel in the 1970s, the use of antimony based treatments fell out of use.[13][14]
Tartar emetic was used in the late 19th and early 20th century in patent medicine as remedy for alcohol intoxication, and was first ruled ineffective in the United States in 1941, in United States v. 11 1/4 Dozen Packages of Articles Labeled in Part Mrs. Moffat’s Shoo-Fly Powders for Drunkenness.[15][16]
The New England Journal of Medicine[17] reported a case study of a patient whose wife secretly gave him a dose of a product called "tartaro emetico" which contained trivalent antimony (antimony potassium tartrate) and is sold in Central America as an aversive treatment for alcohol abuse. The patient, who had been out drinking the night before, developed persistent vomiting shortly after being given orange juice with the drug. When admitted to the hospital, and later in the ICU, he experienced severe chest pains, cardiac abnormalities, renal and hepatic toxicity, and nearly died. The Journal reports that "Two years later, he [the patient] reports complete abstinence from alcohol."
Preparation [edit]
Dissolving antimony oxide in tartaric acid is an easy way to obtain the compound.[18]
References [edit]
- ^ McCallum, RI (1977). "President's address. Observations upon antimony". Proceedings of the Royal Society of Medicine 70 (11): 756–63. PMC 1543508. PMID 341167.
- ^ Thomson, SC (1926). "Antimonyall Cupps: Pocula Emetica or Calices Vomitorii". Proceedings of the Royal Society of Medicine 19 (Sect Hist Med): 122.2–128. PMC 1948687. PMID 19985185.
- ^ Weiss, S.; Hatcher, RA (1922). "The Mechanism of the Vomiting Induced by Antimony and Potassium Tartrate (Tartar Emetic)". Journal of Experimental Medicine 37 (1): 97–111. doi:10.1084/jem.37.1.97. PMC 2128404. PMID 19868716.
- ^ Poulin, B.; Lefebvre, G. t.; McNeil, R. (1994). "Effect and Efficiency of Tartar Emetic in Determining the Diet of Tropical Land Birds". The Condor 96 (1): 98–104. doi:10.2307/1369067. JSTOR 1369067.
- ^ Carlisle, J. D.; Holberton, R. L. (2006). "Relative Efficiency of Fecal versus Regurgitated Samples for Assessing Diet and the Deleterious Effects of a Tartar Emetic on Migratory Birds". Journal of Field Ornithology 77 (2): 126–135. doi:10.1111/j.1557-9263.2006.00032.x. JSTOR 27639314.
- ^ Diamond, Antony W.; Fayad, V. C.; McKinley, Peter S. (2007). "Commentary: Ipecac: An Improved Emetic for Wild Birds". Journal of Field Ornithology 78 (4): 436–439. doi:10.1111/j.1557-9263.2007.00136.x. JSTOR 27715221.
- ^ a b Low, George C. (1916). "The history of the use of intravenous injections of tartar emetic (Antimonium tartaratum) in tropical medicine". Transactions of the Royal Society of Tropical Medicine and Hygiene 10 (2): 37. doi:10.1016/S0035-9203(16)90068-3.
- ^ Navarro, Maribel; Gabbiani, Chiara; Messori, Luigi; Gambino, Dinorah (2010). "Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: Recent achievements and perspectives". Drug Discovery Today 15 (23–24): 1070–8. doi:10.1016/j.drudis.2010.10.005. PMID 20974285.
- ^ Christopherson, J.B. (1918). "The Successful Use of Antimony in Bilharziosis". The Lancet 192 (4958): 325. doi:10.1016/S0140-6736(01)02807-0.
- ^ Crichton-Harris, Ann (2009-07-15). Poison in small measure: Dr. Christopherson and the cure for bilharzia. ISBN 978-90-04-17541-9.
- ^ Sabah, A.A.; Fletcher, Cathy; Webbe, G.; Doenhoff, M.J. (1986). "Schistosoma mansoni: Chemotherapy of infections of different ages". Experimental Parasitology 61 (3): 294–303. doi:10.1016/0014-4894(86)90184-0. PMID 3086114.
- ^ t'Ao, S. C. (1957). "Cardiac manifestations of the toxic action of potassium antimony tartrate in schistosomiasis patients: Paroxysmal ventricular tachycardia and fibrillation". Chinese medical journal 75 (5): 365–378. PMID 13447130. edit
- ^ Hagan, Paul (2009). "Schistosomiasis – a rich vein of research". Parasitology 136 (12): 1611–9. doi:10.1017/S003118200999093X. PMID 19691867.
- ^ Publishers, Bentham Science (1996-10). "The Antimonials". Current Medicinal Chemistry. pp. 304–305.
- ^ Silverman, Matt (2003). Loony lawsuits. Barnes & Noble Books. p. 81. ISBN 9780760738931. Retrieved 1 January 2013.
- ^ "United States v. 111/4 DOZEN PACKAGES, ETC....". Retrieved 1 January 2013.
- ^ Cabot, Richard C.; Harris, Nancy Lee; Shepard, Jo-Anne O.; Rosenberg, Eric S.; Cort, Alice M.; Ebeling, Sally H.; Peters, Christine C.; MacÍas Konstantopoulos, Wendy et al. (2012). "Case 22-2012". New England Journal of Medicine 367 (3): 259. doi:10.1056/NEJMcpc1111580.
- ^ Knapp, Fr. (1839). "Zur Bildungsgeschichte des Brechweinsteins". Annalen der Pharmacie 32: 76. doi:10.1002/jlac.18390320107.
Further reading [edit]
- Priesner, Claus (1997). "Basilius Valentinus und die Labortechnik um 1600". Berichte zur Wissenschaftsgeschichte 20 (2–3): 159. doi:10.1002/bewi.19970200205.
- Geoffroy, M.; Stack, T. (1751). "Observations on the Effects of the Vitrum Antimonii Ceratum, by Mons. Geoffroy, of the Royal Academy of Sciences, and F. R. S. Translated from the French by Tho. Stack, M. D. F. R. S". Philosophical Transactions 47: 273–278. doi:10.1098/rstl.1751.0042. JSTOR 105054.
- Berzelius, Jöns Jacob (1824). Lehrbuch der Chemie.
- Copus, Martinus (1569). Das Spißglas in ein Glas gegossen, das man Vitrum Antimonii nennt, ein wahrhafftige Gift vnd gantzgeferliche Artzney sey.
- The Technologist. 1861.
- "Captain Cook's Antimony Cup". Vesalius, VII, 2: 62–64. 2001.
- Schneider, R. (1859). "Ueber einige Antimon-Verbindungen". Annalen der Physik und Chemie 184 (11): 407. Bibcode:1859AnP...184..407S. doi:10.1002/andp.18591841104.
- Groschuff, E. (1918). "Reines Antimon". Zeitschrift für anorganische und allgemeine Chemie 103: 164. doi:10.1002/zaac.19181030109.
- Soubeiran, E.; Capitaine, H. (1840). "Zur Geschichte der Weinsteinsäure". Journal für Praktische Chemie 19: 435. doi:10.1002/prac.18400190171.
- Pfaff, C. H. (1838). "Ueber Antimon-Wasserstoffgas und die davon abhängige Unsicherheit des von James Marsh entdeckten Verfahrens zur Entdeckung des Arseniks". Archiv der Pharmazie 64 (2): 169. doi:10.1002/ardp.18380640215.
- Zimmermann, E. (1930). "Das Antimon in der Chemotherapie". Klinische Wochenschrift 9: 27. doi:10.1007/BF01740712.
- Gress, Mary E.; Jacobson, Robert A. (1974). "X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(d-C4H2O6)2·3H2O (tarter emetic)". Inorganica Chimica Acta 8: 209. doi:10.1016/S0020-1693(00)92617-3.
UpToDate Contents
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English Journal
- Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against Sb(III)-sensitive and -resistant parasites.
- Lizarazo-Jaimes EH1, Reis PG2, Bezerra FM2, Rodrigues BL1, Monte-Neto RL3, Melo MN4, Frézard F2, Demicheli C5.Author information 1Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.2Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.3Infectious Disease Research Centre, Laval University, 2705 Boulevard Laurier, RC-709, G1V 4G2 Québec, QC, Canada.4Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.5Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil. Electronic address: demichel@netuno.lcc.ufmg.br.AbstractNovel trivalent antimony complexes with the nitrogen donor heterocyclic ligand 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen) or dipyrido[3,2-d:2',3'-f]quinoxaline (dpq) have been synthesized by the reaction with SbCl3 or PhSbCl2. The crystal structures of [Sb(phen)Cl3] and [PhSb(phen)Cl2]CH3COOH were determined and shown to adopt a distorted square pyramid geometry with a five-coordinated Sb center. Surprisingly, all the complexes, the ligands and PhSbCl2 showed very high antileishmanial activities, with IC50 in the nanomolar range against Sb(III)-sensitive and -resistant Leishmania infantum (syn. Leishmania chagasi) and Leishmania amazonensis strains. These compounds were much more active against these Leishmania strains than the old trivalent drug potassium antimonyl tartrate. [PhSb(phen)Cl2]CH3COOH complex was found to be the most active compound and the lack of cross-resistance of PhSbCl2 suggests that the transport pathways of this compound across the cell membrane differ from those responsible for the resistance of Leishmania to Sb(OH)3. In the case of the complexes with PhSbCl2, our data supports the model that both ligand and metal contributed to the overall activity of the complex. Furthermore, among the complexes with SbCl3, only bipy showed an improved activity upon complexation. Cytotoxicity evaluations of these compounds against murine peritoneal macrophages showed high selective indexes in the range of 7-70 for [Sb(phen)Cl3], [Sb(bipy)Cl3] and [Sb(dpq)Cl3] complexes, being much more selective than potassium antimonyl tartrate. In conclusion, this study presents a set of new antileishmanial agents including one of the most active Sb-based compounds ever reported, which can contribute to the development of new chemotherapeutic strategies against leishmaniasis including Sb-resistant cases.
- Journal of inorganic biochemistry.J Inorg Biochem.2014 Mar;132:30-6. doi: 10.1016/j.jinorgbio.2013.12.001. Epub 2013 Dec 19.
- Novel trivalent antimony complexes with the nitrogen donor heterocyclic ligand 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen) or dipyrido[3,2-d:2',3'-f]quinoxaline (dpq) have been synthesized by the reaction with SbCl3 or PhSbCl2. The crystal structures of [Sb(phen)Cl3] and [PhSb(phen)Cl2]CH3COO
- PMID 24412095
- Molecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony.
- Moreira DS1, Monte Neto RL2, Andrade JM1, Santi AM1, Reis PG3, Frézard F3, Murta SM1.Author information 1Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou - CPqRR/FIOCRUZ, Belo Horizonte 30190-002, Minas Gerais, Brazil.2Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil ; Centre de Recherche en Infectiologie, CHUL, Québec G1V 4G2, QC, Canada.3Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.AbstractATP-binding cassette (ABC) transporters have been associated with drug resistance in various diseases. The MRPA gene, a transporter of ABCC subfamily, is involved in the resistance by sequestering metal-thiol conjugates in intracellular vesicles of Leishmania parasite. In this study, we performed the molecular characterization of the MRPA transporter, analysis of P-glycoprotein (Pgp) and aquaglyceroporin-1 (AQP1) expression, and determination of antimony level in antimony-susceptible and -resistant lines of L. (V.) guyanensis, L. (L.) amazonensis, L. (V.) braziliensis and L. (L.) infantum. PFGE analysis revealed an association of chromosomal amplification of MRPA gene with the drug resistance phenotype in all SbIII-resistant Leishmania lines analyzed. Levels of mRNA from MRPA gene determined by real-time quantitative RT-PCR showed an increased expression of two fold in SbIII-resistant lines of Leishmania guyanensis, Leishmania amazonensis and Leishmania braziliensis. Western blot analysis revealed that Pgp is increased in the SbIII-resistant L. guyanensis and L. amazonensis lines. The intracellular level of antimony quantified by graphite furnace atomic absorption spectrometry showed a reduction in the accumulation of this element in SbIII-resistant L. guyanensis, L. amazonensis and L. braziliensis lines when compared to their susceptible counterparts. Interestingly, a down-regulation of AQP1 protein was observed in the SbIII-resistant L. guyanensis and L. amazonensis lines, contributing for decreasing of SbIII entry in these lines. In addition, efflux experiments revealed that the rates of SbIII efflux are higher in the SbIII-resistant lines of L. guyanensis and L. braziliensis, that may explain also the low SbIII concentration within of these parasites. The BSO, an inhibitor of γ-glutamylcysteine synthetase enzyme, reversed the SbIII-resistance phenotype of L. braziliensis and caused an increasing in the Sb intracellular level in the LbSbR line. Our data indicate that the mechanisms of antimony-resistance are different among species of Leishmania analyzed in this study.
- International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2013 Sep 5;3:143-53. doi: 10.1016/j.ijpddr.2013.08.001. eCollection 2013.
- ATP-binding cassette (ABC) transporters have been associated with drug resistance in various diseases. The MRPA gene, a transporter of ABCC subfamily, is involved in the resistance by sequestering metal-thiol conjugates in intracellular vesicles of Leishmania parasite. In this study, we performed th
- PMID 24533304
- Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines.
- Matrangolo FS1, Liarte DB, Andrade LC, de Melo MF, Andrade JM, Ferreira RF, Santiago AS, Pirovani CP, Silva-Pereira RA, Murta SM.Author information 1Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou CPqRR/Fiocruz, Belo Horizonte, MG, Brazil.AbstractThe emergence of drug-resistant Leishmania species is a significant problem in several countries. A comparative proteomic analysis of antimony-susceptible and antimony-resistant Leishmania braziliensis (LbSbR) and Leishmania infantum chagasi (LcSbR) lines was carried out using two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (LC/MS/MS) for protein identification. Out of 132 protein spots exclusive or up-regulated submitted to MS, we identified 80 proteins that corresponded to 57 distinct proteins. Comparative analysis of data showed that most of the protein spots with differential abundance in both species are involved in antioxidant defense, general stress response, glucose and amino acid metabolism, and cytoskeleton organization. Five proteins were commonly more abundant in both SbIII-resistant Leishmania lines: tryparedoxin peroxidase, alpha-tubulin, HSP70, HSP83, and HSP60. Analysis of the protein abundance by Western blotting assays confirmed our proteomic data. These assays revealed that cyclophilin-A is less expressed in both LbSbR and LcSbR lines. On the other hand, the expression of pteridine reductase is higher in the LbSbR line, whereas tryparedoxin peroxidase is overexpressed in both LbSbR and LcSbR lines. Together, these results show that the mechanism of antimony-resistance in Leishmania spp. is complex and multifactorial.
- Molecular and biochemical parasitology.Mol Biochem Parasitol.2013 Aug;190(2):63-75. doi: 10.1016/j.molbiopara.2013.06.006. Epub 2013 Jul 4.
- The emergence of drug-resistant Leishmania species is a significant problem in several countries. A comparative proteomic analysis of antimony-susceptible and antimony-resistant Leishmania braziliensis (LbSbR) and Leishmania infantum chagasi (LcSbR) lines was carried out using two-dimensional gel el
- PMID 23831370
Japanese Journal
- タンニン酸一吐酒石処理による綿布のチューリップ花弁色素による染色
- 佐々木 博昭,丸山 直子,Sasaki Hiroaki,Maruyama Naoko
- 県立新潟女子短期大学研究紀要 32, 119-124, 1995-03
- … Cotton fabrics are pretreated with tannic acid, followed by treatment with tartar emetic. …
- NAID 120002602389
- EFFECT OF AFTERTREATMENT WITH TANNIC ACID ON THE FIXATION OF DISPERSE, ACID, DIRECT AND BASIC DYES
- 小笠原 真次,黒岡 秀次,小泉 誠,黒岩 茂隆
- 繊維学会誌 38(5), T224-T234, 1982
- … Four disperse, 10 acid, 1 direct and 4 basic dyes were used in this experiment.The informations obtained are as follows:1) The wet fastness of these dyes on the fibers is improved by backtanning and further by a successive treatment with tartar emetic (full backtanning).2) The anionic (acid and direct) dyes, which are adsorbed in skin layer of the fiber, are moved into core by backtanning and then tannic acid is adsorbed in the skin layer. …
- NAID 130004203595
- A PECULIAR PHENOMENON, THE PROLAPSUS OF THE ESOPHAGUS-STOMACH, OBSERVED IN THE VOMITING OF THE FROG
- 福原 武,内藤 富夫,亀山 博子
- 日本平滑筋学会雑誌 9(1), 1-8, 1973
- … the results described above, it may be concluded that in the frog the abdominal muscles play a major role in the vomiting, whereas the stomach has no active concern with it.<BR>(2) When 0.5 ml (<I>Rana nigromaculata</I>) or 5 ml (<I>Rana catesbeiana</I>) of the tartar emetic-Ringer solution whose concentration of the emetic was 0.05 g/ml were introduced into the stomach, not only the prolapsus but also the excitation of the movements of the stomach was …
- NAID 130002035511
Related Links
- tartar emeticとは。意味や和訳。[U]化学薬学吐酒石(としゅせき). - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。 ... gooのお知らせ gooヘルスケア「おもいやり食堂」 夏は冷たい飲み物や ...
- a white, water-soluble, sweet and metallic-tasting, poisonous powder or granules, C 4 H 4 KO 7 Sb, used as a mordant for dyeing textiles and leather, and in ... It can slip tartar emetic into the pantry shelves of a scab ...
★リンクテーブル★
[★]
- 主に水酸化リン灰石からなる歯の沈着物歯石、(主に重酒石酸カリウムからなるワイン樽内の沈殿物)酒石
- 関
- calculi、calculus、dental calculi、dental calculus、scale
[★]
- 関
- emesis、emetic agent、emetic drug、emetics、vomit、vomiting
[★]
- 制吐薬、制吐剤、鎮吐薬
- 制吐の,