target protein

• 標的タンパク質、標的タンパク、標的蛋白質、標的蛋白、目的タンパク質、ターゲットタンパク質、ターゲット蛋白質

WordNet

1. intend (something) to move towards a certain goal; "He aimed his fists towards his opponents face"; "criticism directed at her superior"; "direct your anger towards others, not towards yourself" (同)aim, place, direct, point
2. sports equipment consisting of an object set up for a marksman or archer to aim at (同)butt
3. a reference point to shoot at; "his arrow hit the mark" (同)mark
4. the location of the target that is to be hit (同)target area
5. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. (鉄砲などの)『標的』,的,攻撃目標 / (批評・軽べつなどの)的,種《+of+名》 / (行為などの)目標,到達目標
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/31 14:03:06」(JST)

wiki en

[Wiki en表示]

Target proteins are functional biomolecules that are addressed and controlled by biologically active compounds. They are used in the processes of transduction, transformation and conjugation. The identification of target proteins, the investigation of signal transduction processes and the understanding of their interaction with ligands are key elements of modern biomedical research. Since the interaction with target proteins is the molecular origin of most drugs, their particular importance for molecular biology, molecular pharmacy and pharmaceutical sciences is obvious. Target proteins control the action and the kinetic behavior of drugs within the organism. The elucidation of structure, conformational signaling and catalytic properties of particular target proteins facilitates a rational design of drugs and biotechnological processes. Known as biologicals, target proteins can also be drugs by themselves when their modification and formulation is emphasized within the pharmaceutical sciences. Finally, target protein - inducer interactions can be exploited for biomolecular transcription regulating systems in order to control for example gene therapeutic approaches.

See also

• Biological target

References

• Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J (2007). "The reactive metabolite target protein database (TPDB) – a web-accessible resource". BMC Bioinformatics 8: 95. doi:10.1186/1471-2105-8-95. PMC 1832215. PMID 17367530. 

External links

• Target Protein Database of the University of Kansas

UpToDate Contents

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• 1. Protein intake in maintenance hemodialysis patients
• 2. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
• 3. Nutritional status and protein intake in peritoneal dialysis patients
• 4. 成人肝移植における免疫抑制の概要 overview of immunosuppression in adult liver transplantation
• 5. 前立腺癌の分子生物学 molecular biology of prostate cancer

English Journal

• SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.

• Gjerstorff MF1, Relster MM2, Greve KB2, Moeller JB3, Elias D2, Lindgreen JN2, Schmidt S4, Mollenhauer J4, Voldborg B5, Pedersen CB2, Brückmann NH2, Møllegaard NE6, Ditzel HJ7.
• Nucleic acids research.Nucleic Acids Res.2015 Feb 1;42(18):11433-46. doi: 10.1093/nar/gku852. Epub 2014 Sep 23.
• Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein that antagonizes BMI1 and EZH2 PcG body fo
• PMID 25249625

• FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response.

• Chen ZW1, Liu B2, Tang NW1, Xu YH1, Ye XY1, Li ZM1, Niu XM1, Shen SP1, Lu S3, Xu L4.
• Nucleic acids research.Nucleic Acids Res.2015 Feb 1;42(18):11560-9. doi: 10.1093/nar/gku876. Epub 2014 Sep 23.
• Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. Howeve
• PMID 25249620

• Dynamics of RNA modification by a multi-site-specific tRNA methyltransferase.

• Hamdane D1, Guelorget A2, Guérineau V3, Golinelli-Pimpaneau B4.
• Nucleic acids research.Nucleic Acids Res.2015 Feb 1;42(18):11697-706. doi: 10.1093/nar/gku820. Epub 2014 Sep 12.
• In most organisms, the widely conserved 1-methyl-adenosine58 (m(1)A58) tRNA modification is catalyzed by an S-adenosyl-L-methionine (SAM)-dependent, site-specific enzyme TrmI. In archaea, TrmI also methylates the adjacent adenine 57, m(1)A57 being an obligatory intermediate of 1-methyl-inosine57 for
• PMID 25217588

Japanese Journal

• Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

• 2017-03-07
• NAID 120005983409

• Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model

• PLOS ONE 12(3), 2017-03-02
• NAID 120005997927

• Active learning for computational chemogenomics

• Future Medicinal Chemistry 9(4), 381-402, 2017-03
• NAID 120005997743

Related Links

• target proteinの意味・用例｜英辞郎 on the WEB：アルク

target protein 標的タンパク質 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... 英和・和英 対訳データオンライン検索サービス

• Identification of Direct Protein Targets of Small Molecules

Affinity Chromatography as a Classical Method for Target ID Despite the large number of target identification techniques described to date, affinity chromatography remains the most widely used method (55,56). The ...

Related Pictures

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★リンクテーブル★

リンク元	「標的蛋白」「標的蛋白質」「標的タンパク」「標的タンパク質」「目的タンパク質」
関連記事	「target」「targeting」

「標的蛋白」

　　[★]

英

target protein

関

ターゲットタンパク質、ターゲット蛋白質、標的タンパク、標的タンパク質、標的蛋白質、目的タンパク質

「標的蛋白質」

　　[★]

英

target protein

関

ターゲットタンパク質、ターゲット蛋白質、標的タンパク、標的タンパク質、標的蛋白、目的タンパク質

「標的タンパク」

　　[★]

英

target protein

関

ターゲットタンパク質、ターゲット蛋白質、標的タンパク質、標的蛋白、標的蛋白質、目的タンパク質

「標的タンパク質」

　　[★]

英

target protein

関

ターゲットタンパク質、ターゲット蛋白質、標的タンパク、標的蛋白、標的蛋白質、目的タンパク質

「目的タンパク質」

　　[★]

英

target protein

関

ターゲットタンパク質、ターゲット蛋白質、標的タンパク、標的タンパク質、標的蛋白、標的蛋白質

「target」

　　[★]

• n.

• 標的、的、ターゲット

• v.

• 標的にする

　 　 　 　 　

「targeting」

　　[★]

ターゲティング、標的指向化