関: talipexole hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/26 17:23:59」(JST)

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Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996.^[1] As of December 2014 it was not approved for marketing in the US nor in Europe.^[2]

Talipexole is a D₂ dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an α2-adrenergic agonist.^[3]

The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints.^[3] In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.^[4]^:15

References

^ PharmaLetter 22 July 1996 First Launch In Japan For Talipexole
^ EvaluatePharma Database. Page accessed 9 December 2014
^ ^a ^b Benkert O, et al. Dopamine agonists in schizophrenia: a review. Eur Neuropsychopharmacol. 1995;5 Suppl:43-53. PMID 8775758
^ Japanese Ministry of Health, Labour and Welfare March 2008 Pharmaceuticals and Medical Devices Safety Information No. 245

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English Journal

[The therapeutic plasma concentrations of antiparkinson dopamine agonists and their in vitro pharmacology at dopamine receptors].

Tadori Y, Kobayashi H.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.Nihon Shinkei Seishin Yakurigaku Zasshi.2014 Nov;34(5-6):127-32.
This review discusses the relationship between therapeutic plasma concentrations of antiparkinson dopamine agonists (rotigotine, pergolide, cabergoline, apomorphine, bromocriptine, ropinirole, pramipexole, and talipexole) and their in vitro pharmacology at dopamine D1, D2 and D3 receptors. A signifi
PMID 25536763

Drug-induced hypothermia as beneficial treatment before and after cerebral ischemia.

Johansen FF1, Hasseldam H, Rasmussen RS, Bisgaard AS, Bonfils PK, Poulsen SS, Hansen-Schwartz J.
Pathobiology : journal of immunopathology, molecular and cellular biology.Pathobiology.2014;81(1):42-52. doi: 10.1159/000352026. Epub 2013 Aug 23.
OBJECTIVES: Hypothermia is still unproven as beneficial treatment in human stroke, although in animal models, conditioning the brain with hypothermia has induced tolerance to insults. Here, we delineate the feasibility of drug-induced mild hypothermia in reducing ischemic brain damage when condition
PMID 23989388

Do dopamine agonists prevent or reduce the severity of ovarian hyperstimulation syndrome in women undergoing assisted reproduction? A systematic review and meta-analysis.

Baumgarten M1, Polanski L, Campbell B, Raine-Fenning N.
Human fertility (Cambridge, England).Hum Fertil (Camb).2013 Sep;16(3):168-74. doi: 10.3109/14647273.2013.833348.
Controlled ovarian stimulation is an integral part of assisted reproduction treatment. This can result in ovarian hyperstimulation syndrome (OHSS), which is associated with significant morbidity and potentially mortality. Recent approaches to ovarian stimulation have led to a reduction in the preval
PMID 24047196

Japanese Journal

An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice culture

Neuroscience Research 68(4), 315-321, 2010-12
NAID 80021430682

ドパミン神経保護及び神経ネットワークの再構築

YAKUGAKU ZASSHI 130(10), 1263-1272, 2010
NAID 130000451668

薬物療法主な治療薬の種類と特徴ドパミン受容体作動薬--概要,薬理作用,用法・用量,有用性,副作用とその対策タリペキソール (パーキンソン病--基礎・臨床研究のアップデート) -- (治療)

日本臨床 67(-), 355-358, 2009-06
NAID 40016708982

「パーキンソン病治療薬」

Talipexole
Clinical data
Trade names	Domin
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none
Legal status
Legal status	℞ (Prescription only);
Identifiers
	IUPAC name 6-allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine;
Synonyms	Alefexole
CAS Number	36085-73-1
PubChem (CID)	5374
IUPHAR/BPS	5442
ChemSpider	5181
UNII	7AM2J46Z1Y
ChEMBL	CHEMBL1289023
Chemical and physical data
Formula	C10H15N3S
Molar mass	209.31 g/mol
3D model (Jmol)	Interactive image
	SMILES n1c2c(sc1N)CCN(CC2)C\C=C ; ; C=CCN1CCC2=C(CC1)SC(=N2)N ;
	InChI InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12) ; Key:DHSSDEDRBUKTQY-UHFFFAOYSA-N ;
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