talbutal

Talbutal
Systematic (IUPAC) name
	(RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione
Clinical data
Legal status	Schedule III (US)
Identifiers
CAS number	115-44-6
ATC code	N05CA07
PubChem	CID 8275
DrugBank	DB00306
ChemSpider	7976
UNII	4YIR8202AX
ChEMBL	CHEMBL1200802
Synonyms	5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Chemical data
Formula	C11H16N2O3
Mol. mass	224.256 g/mol
	SMILES O=C1NC(=O)NC(=O)C1(C(C)CC)C\C=C;
	InChI InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16) ; Key:BJVVMKUXKQHWJK-UHFFFAOYSA-N ;
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/16 12:01:31」(JST)

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Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.

Pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.^[1]

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl⁻ ionopore at the GABA_A receptor, increasing the duration of time for which the Cl⁻ ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,^[1] and shock.

References

^ ^a ^b Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.

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English Journal

Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons.

Zhai H, Nakatsukasa M, Mitsumoto Y, Fukuyama Y.SourceInstitute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan.
Planta medica.Planta Med.2004 Jul;70(7):598-602.
Talaumidin, a tetrahydrofuran neolignan isolated from the root of Aristolochia arcuata, was shown to be an intriguing small molecule with neurotrophic activity in the primary culture of rat cortical neurons. Talaumidin can promote both dendrite-like and axon-like process outgrowth of cultured rat co
PMID 15303251

1H NMR spectral simplification with achiral and chiral lanthanide shift reagents--IV. Thiopental and barbiturate analogues.

Eberhart ST, Hatzis A, Jimenez J, Rothchild R, Simons P.SourceThe City University of New York, Toxicology Research and Training Center, John Jay College of Criminal Justice, Department of Science, 445 West 59th Street, New York, NY 10019-1199, USA.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.1987;5(3):233-45.
The 60 MHz (1)H NMR spectra of racemic thiopental, 1, have been studied with the achiral shift reagent, tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato) europium(III), 2, and the chiral tris[3-(trifluoromethylhydroxymethylene)-d-camphorato] europium(III), 3, and tris[3-(heptafluoroprop
PMID 16867520

Analysis of barbiturates in blood by high-performance liquid chromatography.

Gill R, Lopes AA, Moffat AC.AbstractA high-performance liquid chromatographic (HPLC) assay for the identification and quantification of barbiturates in blood at therapeutic levels had been developed. An ODS-silica column is used with an eluent of 40% methanol at pH 8.5. The barbiturates are detected at 240 nm. The sample preparation procedure involves extraction of unfractionated blood (100 microliter) with hexane-diethyl ether (50 : 50, v/v) ang is very rapid. Talbutal is used as an internal standard. The method has been applied to the determination of five barbiturates (amylobarbitone, butobarbitone, cyclobarbitone, pentobarbitone and quinalbarbitone) in blood after therapeutic doses of the drugs. An application of the HPLC assay to forensic casework is demonstrated.
Journal of chromatography.J Chromatogr.1981 Nov 13;226(1):117-23.
A high-performance liquid chromatographic (HPLC) assay for the identification and quantification of barbiturates in blood at therapeutic levels had been developed. An ODS-silica column is used with an eluent of 40% methanol at pH 8.5. The barbiturates are detected at 240 nm. The sample preparation p
PMID 7320137

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