tafenoquine

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/20 21:05:24」(JST)

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英文文献

  • Exposure-Response Analyses for Tafenoquine after Administration to Patients with Plasmodium vivax Malaria.
  • Tenero D1, Green JA2, Goyal N3.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Jul 27. pii: AAC.00718-15. [Epub ahead of print]
  • Tafenoquine (TQ), a new 8-aminoquinoline with activity against all stages of the Plasmodium vivax lifecycle, is being developed for the radical cure of acute P. vivax malaria in combination with chloroquine. The efficacy and exposure data from a pivotal Phase 2b dose-ranging study were used to condu
  • PMID 26248362
  • The oral antimalarial drug tafenoquine shows activity against Trypanosoma brucei.
  • Carvalho L1, Martínez-García M1, Pérez-Victoria I2, Manzano JI1, Yardley V3, Gamarro F4, Pérez-Victoria JM4.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Jul 20. pii: AAC.00879-15. [Epub ahead of print]
  • The protozoan parasite Trypanosoma brucei causes Human African Trypanosomiasis, or sleeping sickness, a neglected tropical disease that requires new, safer, and more effective treatments. Repurposing oral drugs could reduce both the time and cost involved in sleeping sickness drug discovery. Tafenoq
  • PMID 26195527
  • Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
  • Vuong C1, Xie LH1, Potter BM1, Zhang J1, Zhang P1, Duan D1, Nolan CK1, Sciotti RJ1, Zottig VE1, Nanayakkara NP2, Tekwani BL3, Walker LA3, Smith PL1, Paris RM1, Read LT1, Li Q1, Pybus BS1, Sousa JC1, Reichard GA1, Smith B4, Marcsisin SR5.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13.
  • Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of the 8-aminoquinoline molecule tafenoquine in mice. This could be problematic for Plasmodium vivax radical cure, as the human CYP 2D ortholog (2D6) is highly polymorphic. Diminished CYP 2D6 enzyme activity, a
  • PMID 25870069

和文文献

  • A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malaria

関連リンク

Tafenoquine Patient confirmatory Project Leader: Dr JP Kleim, GlaxoSmithKline, UK MMV Project Sponsor: Dr Wiweka Kaszubska Tafenoquine is our lead investigational medicine for the treatment of P. vivax (relapsing) malaria. It is ...
back to the Science portfolio Patient confirmatory Project Leader: Dr JP Kleim, GlaxoSmithKline, UK MMV Project Sponsor: Dr Wiweka Kaszubska Tafenoquine is our lead investigational medicine for the treatment of P. vivax (relapsing) malaria.

関連画像

Tafenoquine - GanfydTafenoquine | Buy Tafenoquine from  Prophylactic Efficacy of TafenoquineTafenoquine.svg Prophylactic Efficacy of Tafenoquine Prophylactic Efficacy of Tafenoquine



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