WordNet

any compound that contains water of crystallization
become hydrated and combine with water
cause to be hydrated; add water or moisture to; "hydrate your skin"
supply water or liquid to in order to maintain a healthy balance; "the bicyclists must be hydrated frequently"
small tubular solitary freshwater hydrozoan polyp
trouble that cannot be overcome by a single effort because of its many aspects or its persistent and pervasive quality; "we may be facing a hydra that defies any easy solution"

PrepTutorEJDIC

含水化合物,水化物 / 〈化合物〉‘を'水和させて水化物を作る

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1. シクロスポリンおよびタクロリムスの薬理作用および副作用 pharmacology and side effects of cyclosporine and tacrolimus
2. シクロスポリンおよびタクロリムスの腎毒性 cyclosporine and tacrolimus nephrotoxicity
3. 成人肝移植における免疫抑制の概要 overview of immunosuppression in adult liver transplantation
4. 成人の腎移植における免疫抑制維持療法 maintenance immunosuppressive therapy in renal transplantation in adults
5. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease

English Journal

Paraneoplastic cerebellar degeneration caused by ovarian clear-cell carcinoma.

Negishi Y, Sakai K, Noguchi Y, Iwasaki N, Kawai N.Author information Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan; Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan; Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, Tokyo, Japan.AbstractParaneoplastic cerebellar degeneration is a paraneoplastic neurological syndrome caused by the remote effect of certain systemic cancers and is characterized by subacute cerebellar symptoms. A 62-year-old woman suffering from unidentified cerebellar symptoms was admitted to our hospital. Paraneoplastic cerebellar degeneration was suspected and ovarian cancer was detected after the systemic examination for malignancy. The symptoms of vertigo and dysarthria were improved a little after surgical operation and treatments of γ-globulin, steroid pulse and tacrolimus hydrate. The cerebellar symptoms of paraneoplastic cerebellar degeneration are often evident prior to detection of malignancy. It is important to perform systemic examination for malignancy in case of unidentified cerebellar symptoms.
The journal of obstetrics and gynaecology research.J Obstet Gynaecol Res.2013 Oct 22. doi: 10.1111/jog.12212. [Epub ahead of print]
Paraneoplastic cerebellar degeneration is a paraneoplastic neurological syndrome caused by the remote effect of certain systemic cancers and is characterized by subacute cerebellar symptoms. A 62-year-old woman suffering from unidentified cerebellar symptoms was admitted to our hospital. Paraneoplas
PMID 24148073

Exclusive plaque psoriasis of the lips: efficacy of combination therapy of topical tacrolimus, calcipotriol, and betamethasone dipropionate.

Sehgal VN, Sehgal S, Verma P, Singh N, Rasool F.Author information Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati-Delhi 110 033, India. drsehgal@ndf.vsnl.net.inAbstractA 16-year-old unmarried woman presented with recurrent cracking of the lips indicated by the appearance of grayish white flakes since October 2004, which, in due course, shed off leaving behind an apparently normal mucous membrane. Chewing roasted corn treated with salt and lemon (bhutta) initially caused the lesions. Ever since, it has been a cause of its exacerbation. She never had any relief with either systemic or topical treatment. In fact, an obsession had overtaken her, resulting in a psychological setback. She denied regular drug use for any other ailment. Her menstrual cycle was normal. There was a positive history of psoriasis in her mother. Examination of the lips was conspicuous. It was marked by the presence of a well-circumscribed, moist, raised plaque (Figure 1). Its surface was irregular, with elevation and depression. It was made up of thick, grayish white scales, which were arranged in layers; however, Grattage/Auspitz sign could not be elicited. Fissuring was prominent but the buccal mucosa, surface of the tongue, gingiva, and palate were normal. The clinical examination did not reveal any evidence of skin and/or nail psoriasis/psoriatic arthropathy or any other systemic abnormality. Blood examination including total and differential leukocyte count, complete hemogram, and liver and renal function tests were normal. Biopsy of the representative lesion was subjected to serial sections. They were stained with hematoxylin-eosin to work up microscopic pathology. It revealed the presence of mounds of parakeratosis with numerous neutrophilic Munro microabscesses (Figure 2). Submucosal vessels were dilated and congested. Periodic-acid-Schiff (PAS) stain revealed fungal hyphae and spores within the parakeratotic layer. Colonies of Gram-positive cocci were also demonstrated on the surface of the mucosa. She was administered combination therapy, comprising topical tacrolimus (0.1%) ointment and calcipotirol hydrate (50 microg/g) plus betmethasone dipropionate (0.5 mg/g) twice a day for 7 days. A single bolus dose of fluconazole 450 mg orally was also administered. The response to treatment was favorable and the lesions showed regression (Figure 3).
Skinmed.Skinmed.2012 May-Jun;10(3):183-4.
A 16-year-old unmarried woman presented with recurrent cracking of the lips indicated by the appearance of grayish white flakes since October 2004, which, in due course, shed off leaving behind an apparently normal mucous membrane. Chewing roasted corn treated with salt and lemon (bhutta) initially
PMID 22779103

Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide.

Masuoka E, Bito T, Shimizu H, Nishigori C.Author information Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.AbstractWe report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin-positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug-induced photoleukomelanoderma.
Photodermatology, photoimmunology & photomedicine.Photodermatol Photoimmunol Photomed.2011 Dec;27(6):328-30. doi: 10.1111/j.1600-0781.2011.00614.x.
We report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and co
PMID 22092738

Japanese Journal

生体肝移植後患者に発症した大腸癌の1例

中尾寿宏,篠原永光,豊田剛,木下貴史,吉田禎宏
日本消化器外科学会雑誌 45(7), 794-800, 2012
症例は54歳の女性で，47歳時に原発性胆汁性肝硬変による肝不全に対し，生体肝移植を施行後，免疫抑制剤を投与されていた．53歳頃より血便が出現し，CTにて直腸S状部に壁の肥厚，大腸内視鏡検査にて直腸S状部にBorrmann 3型腫瘤を認め，生検の結果，中分化型腺癌と診断された．高位前方切除術，リンパ節郭清を施行した．病理組織診断は，pSS，pN1，Cy1，INFb，ly1，v1，pPM0，pDM0， …
NAID 130004560857

A Case of Cutaneous Cryptococcosis Presenting with Broad Induration and Necrotic Skin Lesions

奥山歩美,南祥一郎
皮膚の科学 11(1), 87-91, 2012
… A 73-year-old male on immunosuppressive therapy such as tacrolimus hydrate and prednisolone for myasthenia gravis initially presented with swelling and erythema of the right lower leg. …
NAID 130004546902

SLEを基礎疾患とした続発型皮膚クリプトコッカス症の1例

渡辺真也,飯島茂子,海老原至
西日本皮膚科 74(1), 37-42, 2012
73歳，女性。農業に従事し，鳥の飼育歴はない。ループス腎炎のため，プレドニゾロン20mg，タクロリムス3mg内服約1ヵ月後より左大腿内側に痛みを伴う紅斑が出現した。初診時，6×6cmの皮内から皮下に及ぶ硬結と紅斑を認めた。皮膚生検にて真皮深層から脂肪織にかけて多数の小円形物質があり，小円形物質はPAS染色，グロコット染色陽性であった。また，塗沫標本の墨汁法にて莢膜を有する菌体を確認した。画像所見に …
NAID 130004475428