WordNet

executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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1. 成人における肝移植：免疫抑制の概要 liver transplantation in adults overview of immunosuppression
2. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
3. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease
4. シクロスポリンおよびタクロリムスの薬理作用および副作用 pharmacology and side effects of cyclosporine and tacrolimus
5. 成人の腎移植における免疫抑制維持療法 maintenance immunosuppressive therapy in renal transplantation in adults

Yan Z1, Bai XC2, Yan C3, Wu J3, Li Z4, Xie T3, Peng W4, Yin CC5, Li X6, Scheres SH2, Shi Y3, Yan N4.
Nature.Nature.2015 Jan 1;517(7532):50-5. doi: 10.1038/nature14063. Epub 2014 Dec 15.
The ryanodine receptors (RyRs) are high-conductance intracellular Ca(2+) channels that play a pivotal role in the excitation-contraction coupling of skeletal and cardiac muscles. RyRs are the largest known ion channels, with a homotetrameric organization and approximately 5,000 residues in each prot
PMID 25517095

Efremov RG1, Leitner A2, Aebersold R3, Raunser S4.
Nature.Nature.2015 Jan 1;517(7532):39-43. doi: 10.1038/nature13916. Epub 2014 Dec 1.
Muscle contraction is initiated by the release of calcium (Ca(2+)) from the sarcoplasmic reticulum into the cytoplasm of myocytes through ryanodine receptors (RyRs). RyRs are homotetrameric channels with a molecular mass of more than 2.2 megadaltons that are regulated by several factors, including
PMID 25470059

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.

Umanskaya A1, Santulli G1, Xie W1, Andersson DC1, Reiken SR1, Marks AR2.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Oct 21;111(42):15250-5. doi: 10.1073/pnas.1412754111. Epub 2014 Oct 6.
Age-related skeletal muscle dysfunction is a leading cause of morbidity that affects up to half the population aged 80 or greater. Here we tested the effects of increased mitochondrial antioxidant activity on age-dependent skeletal muscle dysfunction using transgenic mice with targeted overexpressio
PMID 25288763