systemic candidiasis

全身性カンジダ症 SC

WordNet

1. (physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
2. instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
3. a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
4. a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
5. a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
6. a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
7. the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
8. affecting an entire system; "a systemic poison"
9. an infection caused by fungi of the genus Monilia or Candida (especially Candida albicans) (同)moniliasis, monilia disease

PrepTutorEJDIC

1. 〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
2. (身体・言語のように)体系の,組織の / 全身の,全身的

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/19 23:11:23」(JST)

wiki en

[Wiki en表示]

Systemic candidiasis is an infection of Candida albicans causing disseminated disease and sepsis, invariably when host defenses are compromised.

See also

• Candidiasis
• Skin lesion
• List of cutaneous conditions

References

UpToDate Contents

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• 1. 成人におけるカンジダ菌血症および侵襲性カンジダ症 treatment of candidemia and invasive candidiasis in adults
• 2. カンジダ感染症の概要 overview of candida infections
• 3. 成人におけるカンジダ菌血症および侵襲性カンジダ症の臨床症状および診断 clinical manifestations and diagnosis of candidemia and invasive candidiasis in adults
• 4. 小児におけるカンジダ感染症の概要 overview of candida infections in children
• 5. 慢性粘膜皮膚カンジダ症 chronic mucocutaneous candidiasis

English Journal

• CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

• Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, Wan W, Lee CC, Lim JK, Rivollier A, Yang JC, Laird GM, Wheeler RT, Alexander BD, Perfect JR, Gao JL, Kullberg BJ, Netea MG, Murphy PM.AbstractSystemic Candida albicans infection causes high morbidity and mortality and is associated with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly defined. Here, using a mouse model of systemic candidiasis, we found that resident macrophages accumulated in the kidney, the main target organ of infection, and formed direct contacts with the fungus in vivo mainly within the first few hours after infection. Macrophage accumulation and contact with Candida were both markedly reduced in mice lacking chemokine receptor CX3CR1, which was found almost exclusively on resident macrophages in uninfected kidneys. Infected Cx3cr1-/- mice uniformly succumbed to Candida-induced renal failure, but exhibited clearance of the fungus in all other organs tested. Renal macrophage deficiency in infected Cx3cr1-/- mice was due to reduced macrophage survival, not impaired proliferation, trafficking, or differentiation. In humans, the dysfunctional CX3CR1 allele CX3CR1-M280 was associated with increased risk of systemic candidiasis. Together, these data indicate that CX3CR1-mediated renal resident macrophage survival is a critical innate mechanism of early fungal control that influences host survival in systemic candidiasis.
• The Journal of clinical investigation.J Clin Invest.2013 Nov 1. pii: 71307. doi: 10.1172/JCI71307. [Epub ahead of print]
• Systemic Candida albicans infection causes high morbidity and mortality and is associated with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly defined. Here, using a mouse model of systemic candidiasis, we found that resident macrophages accumulated in the kid
• PMID 24177428

• Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis.

• Ibrahim F, Sivak O, Wasan EK, Bartlett K, Wasan KM.AbstractOBJECTIVE: An oral lipid based formulation that exhibits tropical stability (iCo-010) was developed to enhance the absorption of orally administered amphotericin B (AmB). iCo-010 has previously shown high efficacy in an acute model of systemic candidiasis in rats, directing the focus of this study to be its efficacy in a chronic model of systemic candidiasis in mice.
• Lipids in health and disease.Lipids Health Dis.2013 Oct 29;12(1):158. [Epub ahead of print]
• OBJECTIVE: An oral lipid based formulation that exhibits tropical stability (iCo-010) was developed to enhance the absorption of orally administered amphotericin B (AmB). iCo-010 has previously shown high efficacy in an acute model of systemic candidiasis in rats, directing the focus of this study t
• PMID 24164705

• Comparison of the T2Dx instrument with T2Candida assay and automated blood culture in the detection of Candida species using seeded blood samples.

• Beyda ND, Alam MJ, Garey KW.SourceUniversity of Houston College of Pharmacy, Houston, TX.
• Diagnostic microbiology and infectious disease.Diagn Microbiol Infect Dis.2013 Oct 14. pii: S0732-8893(13)00400-8. doi: 10.1016/j.diagmicrobio.2013.07.007. [Epub ahead of print]
• As a delay in the diagnosis and treatment of candidemia is associated with increased mortality and healthcare costs, a more rapid method of detection is urgently needed. The T2Candida assay is a new rapid diagnostic test, which uses T2 magnetic resonance technology to identify Candida spp. directly
• PMID 24135411

Japanese Journal

• 実験的マウス口腔カンジダ症モデルを用いた <I>Candida dubliniensis</I> と <I>Candida albicans</I> の病原性の比較

• 吉岡 裕雄,久和 彰江,仲村 健二郎,又賀 泉
• Medical Mycology Journal 53(2), 135-145, 2012
• ある種のカンジダ属は日和見感染菌として知られており，特に <I>Candida albicans</I> は強い病原性を有して口腔カンジダ症の原因菌として検出される．近年，HIV 陽性患者や免疫不全患者から分離され，また健常者からも検出される新菌種 <I>C. dubliniensis</I> は，形態や分子生物学的性状が <I>C. a …
• NAID 130001921808

• Protective Role of Naturally Occurring Interleukin-17A-Producing γδ T Cells in the Lung at the Early Stage of Systemic Candidiasis in Mice

• Dejima Takashi,Shibata Kensuke,Yamada Hisakata,Hara Hiromitsu,Iwakura Yoichiro,Naito Seiji,Yoshikai Yasunobu,柴田 健輔
• Infection and Immunity 79(11), 4503-4510, 2011-11-00
• NAID 120005133052

• Antimicrobial Activity of Gel-Entrapped Catechins toward Oral Microorganisms

• Tamura Muneaki,Saito Hideo,Kikuchi Kuniyoshi,Ishigami Tomohiko,Toyama Yoshio,Takami Masao,Ochiai Kuniyasu
• Biological and Pharmaceutical Bulletin 34(5), 638-643, 2011
• … An increase in the number of these microorganisms may result in systemic diseases such as infective endocarditis and aspiration pneumonia as well as oral infections. … These results suggest that GEC may be useful for controlling oral microorganism populations and reducing the accumulation of dental plaque, thereby helping to prevent periodontal disease and oral candidiasis. …
• NAID 130000657773

Related Links

• Systemic Candidiasis and HIV Disease - TheBody.com

Candidiasis is an infection with the fungus called Candida. It's among the most common conditions seen in people with HIV, and often the first illness and sign that HIV disease is progressing to a more severe stage.

• Systemic candidiasis Symptoms, Diagnosis, Treatments ...

Systemic candidiasis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. ... Systemic candidiasis: Introduction Systemic candidiasis: A candida ...

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★リンクテーブル★

リンク元	「SC」「全身性播種性カンジダ症」「全身性カンジダ症」
拡張検索	「congenital systemic candidiasis」
関連記事	「systemic」「system」「candidiasis」

「SC」

　　[★]

• 分泌成分 secretory component
• 皮下の subcutaneous
• systemic candidiasis

「全身性播種性カンジダ症」

　　[★]

英

systemic disseminated candidiasis, systemic candidiasis

「全身性カンジダ症」

　　[★]

英

systemic candidiasis

関

カンジダ症

「congenital systemic candidiasis」

　　[★] 先天性全身性カンジダ症

「systemic」

　　[★]

• adj.

• 全身性の、全身的な、全身の、(植物)浸透移行性の

関

general、generalized、systemically、total body、whole body、whole-body

　 　

「system」

　　[★]

• n.

• 系、システム、体系、体制、方式

関

method、series、strain

　 　 　 　 　 　 　 　

「candidiasis」

　　[★]

(pl.)candidiase

• カンジダ症