surfactant protein A

同

SP-A

WordNet

1. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
2. the 1st letter of the Roman alphabet (同)a
3. the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

1. 蛋白(たんばく)質
2. answer / ampere
3. arsenicの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/14 15:21:10」(JST)

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[Wiki en表示]

surfactant, pulmonary-associated protein A1
Identifiers
Symbol	SFTPA1
Alt. symbols	SFTP1
Entrez	6435
HUGO	10798
OMIM	178630
RefSeq	NM_005411
UniProt	Q8IWL2
Other data
Locus	Chr. 10 q22.3

surfactant, pulmonary-associated protein A2B
Identifiers
Symbol	SFTPA2B
Entrez	6436
HUGO	10799
OMIM	178642
RefSeq	NM_006926
UniProt	Q8IWL1
Other data
Locus	Chr. 10 q22.3

Surfactant protein A is an innate immune system collectin. It is water soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism.

During Parturition

The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice. Mice which gestate for 19 days typically show signs of SP-A in amniotic fluid at around 16 days. If SP-A is injected into the uterus at 15 days, mice typically deliver early. Inversely, an SP-A inhibitor injection causes notable delays in birth.

The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans. In fact, the level of SP-A in a human uterus typically decreases during labor.

Immune Functions

Research on SP-A has been done mainly in rodents including mice and rats. This research has shown that mice deficient in SP-A are more susceptible to infections from group B Streptoccoal organisms, Pseudomonas aeruginosa, and likely other organisms. The immune functions of SP-A are time, temperature, and concentration dependant.

Location

SP-A is found in the pulmonary surfactant in lungs. SP-A and SP-D are also present in extrapulmonary tissues.

See also

• pulmonary surfactant
• SFTPA1
• SFTPA2B

External links

• Surfactant Protein A at the US National Library of Medicine Medical Subject Headings (MeSH)

References

UpToDate Contents

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• 1. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
• 2. 胎便吸引症候群の臨床的特徴および診断 clinical features and diagnosis of meconium aspiration syndrome
• 3. 成人における肺胞蛋白症の臨床症状および病因 clinical manifestations and etiology of pulmonary alveolar proteinosis in adults
• 4. 間質性肺疾患を有する成人に対するアプローチ：診断的検査 approach to the adult with interstitial lung disease diagnostic testing
• 5. 間質性肺疾患を有する幼児および小児に対するアプローチ approach to the infant and child with interstitial lung disease

English Journal

• Novel role of surfactant protein A in bacterial sinusitis.

• Noutsios GT1, Willis AL1, Ledford JG2, Chang EH1.
• International forum of allergy & rhinology.Int Forum Allergy Rhinol.2017 Jul 20. doi: 10.1002/alr.21985. [Epub ahead of print]
• PMID 28727907

• Microbiota Composition and Pulmonary Surfactant Protein Expression as Markers of Death by Drowning.

• Lee SY1, Woo SK1, Lee SM2, Ha EJ2, Lim KH2, Choi KH3, Roh YH3, Eom YB1,2.
• Journal of forensic sciences.J Forensic Sci.2017 Jul;62(4):1080-1088. doi: 10.1111/1556-4029.13347. Epub 2017 Jan 18.
• PMID 28097647

• Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

• Lugogo N1, Francisco D2, Addison KJ2, Manne A2, Pederson W2, Ingram JL1, Green CL3, Suratt BT4, Lee JJ5, Sunday ME6, Kraft M2, Ledford JG7.
• The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2017 Jun 15. pii: S0091-6749(17)30935-1. doi: 10.1016/j.jaci.2017.05.028. [Epub ahead of print]
• PMID 28624607

Japanese Journal

• Pulmonary effects in workers exposed to indium metal : A cross-sectional study

• NAKANO Makiko,TANAKA Akiyo,HIRATA Miyuki [他]
• Journal of Occupational Health 57(4), 346-352, 2015-07
• NAID 40020547413

• Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice

• Tobinaga Shuichi,Matsumoto Keitaro,Nagayasu Takeshi,Furukawa Katsuro,Abo Takafumi,Yamasaki Naoya,Tsuchiya Tomoshi,Miyazaki Takuro,Koji Takehiko
• Acta Histochemica et Cytochemica 48(3), 83-94, 2015-06-29
• … In the lung, the expression of proliferating cell nuclear antigen (PCNA) was augmented, and surfactant protein A (SP-A) and KGF receptor (KGFR) were co-expressed in PCNA-positive cells. …
• NAID 120005627352

• ATP測定法を用いたマイクロ・ナノバブルの洗浄力評価

• 山口 庸子,中村 弥生,Yoko Yamaguchi,Yayoi Nakamura
• 共立女子短期大学生活科学科紀要 = Annual bulletin, Department of the Science of Living 58, 57-65, 2015-02
• … We found plain gelatin, milk gelatin, and green tea gelatin, used to model protein contamination, to be suitable model contaminants when measuring the quantity of ATP alone or in combination with adenosine monophosphate (AMP) for ATP testing method. …
• NAID 120005598462

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★リンクテーブル★

リンク元	「サーファクタント関連タンパク質」「SP-A」
関連記事	「A」「Ad」「surfactant」

「サーファクタント関連タンパク質」

　　[★]

英

surfactant protein

関

[[]]

• surfactant protein A SP-A
• surfactant protein B SP-B
• surfactant protein C SP-C
• surfactant protein D SP-D

「SP-A」

　　[★]

英

surfactant protein A

同

サーファクタントプロテインA

関

KL-6, SP-D

「A」

　　[★]

• アデニン adenine
• アデノシン adenosine
• アラニン alanine

　 　 　

「Ad」

　　[★]

• アデノウイルス

関

adenoviral、adenovirus

「surfactant」

　　[★]

• n.

• 界面活性剤、サーファクタント