腓腹神経生検

WordNet

any bundle of nerve fibers running to various organs and tissues of the body (同)nervus
one of the sections (or chapters) in the Koran; "the Quran is divided in 114 suras"
examination of tissues or liquids from the living body to determine the existence or cause of a disease
control of your emotions; "this kind of tension is not good for my nerves"

PrepTutorEJDIC

〈C〉『神経』 / 〈C〉《複数形で》『神経過敏』,いらだち / 〈U〉『勇気』,度胸(courage) / 〈U〉《時にa ~》厚かましさ,ずぶとさ;無礼 / 〈C〉葉脈;(昆虫の)翅脈(しみゃく) / 〈人,特に自分〉‘に'力を与える,‘を'元気づける

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1. 末梢神経疾患および筋疾患の鑑別診断 differential diagnosis of peripheral nerve and muscle disease
2. 血管炎性ニューロパチーの診断および治療 diagnosis and treatment of vasculitic neuropathy
3. 多発性神経障害の概要 overview of polyneuropathy
4. 末梢神経障害の評価のための皮膚生検 skin biopsy for the evaluation of peripheral nerve disease
5. 遺伝性感覚自律神経ニューロパチー hereditary sensory and autonomic neuropathies

English Journal

Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells.

Yokoi S1, Kawagashira Y1, Ohyama K1, Iijima M1, Koike H1, Watanabe H1, Tatematsu A2, Nakamura S2, Sobue G3.Author information 1Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya466-8550, Japan.2Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya466-8550, Japan.3Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya466-8550, Japan. Electronic address: sobueg@med.nagoya-u.ac.jp.AbstractWe describe a 54-year-old man with mononeuritis multiplex and reactive lymphoid hyperplasia with increased immunoglobulin G4 (IgG4)-positive cells. Asymmetrical numbness and weakness had advanced stepwise for 6 years. Serum immunoglobulin G, IgG4, and immunoglobulin E levels were elevated, whereas M protein was not detected. Chest and abdominal computed tomography showed generalized lymphadenopathy. Inguinal lymph node biopsy revealed expansion of the interfollicular area with infiltration of IgG4-positive cells, of which the absolute number was greater than 100 per high-power field, and the percentage of IgG4+/immunoglobulin G+ plasma cells was 33%. Sural nerve biopsy disclosed axonal neuropathy with tumefactive lymphoid infiltrate in epineurium, but IgG4-positve plasma cells and fibrosis were not detected. Symptoms and laboratory data were improved with oral glucocorticoid therapy at a dose of 0.6 mg/kg per day. Although the causal mechanisms of neuropathy should be determined in future studies, peripheral nerve involvement may occur in patients with reactive lymphoid hyperplasia with increased IgG4-positive cells.
Human pathology.Hum Pathol.2014 Feb;45(2):427-30. doi: 10.1016/j.humpath.2013.07.047. Epub 2013 Nov 27.
We describe a 54-year-old man with mononeuritis multiplex and reactive lymphoid hyperplasia with increased immunoglobulin G4 (IgG4)-positive cells. Asymmetrical numbness and weakness had advanced stepwise for 6 years. Serum immunoglobulin G, IgG4, and immunoglobulin E levels were elevated, whereas M
PMID 24289971

Gait Disturbance due to Foot Drop Is Refractory to Treatment in Nonsystemic Vasculitic Neuropathy.

Hirahara T, Yamashita S, Misumi Y, Kawakami K, Hori H, Honda S, Watanabe M, Ikeda T, Yamashita T, Maeda Y, Ando Y.Author information Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.AbstractBackground: Nonsystemic vasculitic neuropathy (NSVN) is a vasculitis syndrome clinically restricted to the peripheral nervous system. Although treatment may improve prognosis, daily activities of such patients after treatment have not been well studied. Methods: We evaluated clinical features, laboratory data, nerve conduction, and sural nerve biopsy findings for 16 unbiased consecutive patients with NSVN. Results: Initial symptoms included neuropathic pain (31%) and lower limb sensory disturbance (19%). The mean duration between disease onset and initial treatment was 4.1 ± 4.8 months. Mean modified Rankin scale scores were 3.13 at hospital admission and 2.69 at final follow-up. The poor outcome group had significantly decreased compound muscle action potentials of peroneal nerves and significantly more patients presenting with foot drop compared with the good outcome group. No other significant differences were found. Conclusion: Pretreatment foot drop signaled poor outcome in daily activities of patients with NSVN, and earlier treatment may be critical for these patients. © 2014 S. Karger AG, Basel.
European neurology.Eur Neurol.2014 Jan 21;71(3-4):180-186. [Epub ahead of print]
Background: Nonsystemic vasculitic neuropathy (NSVN) is a vasculitis syndrome clinically restricted to the peripheral nervous system. Although treatment may improve prognosis, daily activities of such patients after treatment have not been well studied. Methods: We evaluated clinical features, labor
PMID 24457445

Cutaneous activation of rage in non-systemic vasculitic and diabetic neuropathy.

Bekircan-Kurt CE, Uçeyler N, Sommer C.Author information Department of Neurology, University of Würzburg, Würzburg, Germany.AbstractIntroduction: We asked whether the receptor of advanced glycation end products (RAGE) is related to dermal inflammation in non-systemic vasculitic neuropathy (NSVN) and diabetic neuropathy (DN) and whether its presence in skin is comparable to that in sural nerve biopsies. Methods: We immunoreacted skin biopsy samples from 17 NSVN and 7 DN patients who had also undergone sural nerve biopsy, and 14 healthy controls with antibodies to advanced glycation end products (AGE), RAGE, T-cells, and macrophages. Results: AGE and RAGE immunoreactivity were present in vessels of nerve biopsies from NSVN and DN. AGE and RAGE were increased in dermal endothelial cells and T-cells of NSVN and DN patients compared to controls. Conclusion: Dermal RAGE is increased in NSVN and DN, supporting the concept of a role of the RAGE pathway in the pathophysiology of dermal inflammation and skin denervation in NSVN and DN. © 2013 Wiley Periodicals, Inc.
Muscle & nerve.Muscle Nerve.2014 Jan 7. doi: 10.1002/mus.24164. [Epub ahead of print]
Introduction: We asked whether the receptor of advanced glycation end products (RAGE) is related to dermal inflammation in non-systemic vasculitic neuropathy (NSVN) and diabetic neuropathy (DN) and whether its presence in skin is comparable to that in sural nerve biopsies. Methods: We immunoreacted
PMID 24395344

Japanese Journal

中枢・末梢連合脱髄症（combined central and peripheral demyelination）の1例

野中俊章,藤本武士,江口勝美,福田安雄,吉村俊朗
臨床神経学 55(6), 389-394, 2015
症例は22歳，男性．10歳頃より走るのが遅くなった．2011年6月より歩行時のふらつきが出現し，当科紹介入院となった．入院時，四肢筋力低下や凹足，痙性歩行がみられた．MRIで大脳深部白質や脳幹，胸髄などに多発する病変がみとめられた．末梢神経伝導検査にて上下肢の運動神経伝導速度の著明な低下と腓腹神経生検にて脱髄所見をみとめた．治療はステロイドパルス療法を2クール施行し，その後インターフェロンβ自己注 …
NAID 130005083888

血管炎性ニューロパチーの新しい分類と診断・治療

神田隆
臨床神経学 54(12), 1050-1052, 2014
原発性血管炎分類の国際的スタンダードであるChapel Hill Consensus Conference 分類は大幅に改定され，CHCC2012として発表された．ANCA関連血管炎に関しても個々の疾患名の大幅な見直しがなされ，Wegener肉芽腫症は多発血管炎性肉芽腫症GPAに，アレルギー性肉芽腫性血管炎は好酸球性多発血管炎性肉芽腫症EGPAに名称が変更された．血管炎性ニューロパチーの確定診断に …
NAID 130004921201

IgG4関連ニューロパチーの臨床と病理

大山健,小池春樹,高橋美江,川頭祐一,飯島正博,祖父江元
臨床神経学 54(12), 1047-1049, 2014
近年，IgGのサブクラスのひとつであるIgG4の上昇をともなう疾患群がIgG4関連疾患（IgG4-RD）として報告され，注目されている．IgG4-RDは，臓器の腫脹・腫大，組織での線維化をともなうIgG4陽性形質細胞浸潤，血清IgG4値の上昇を共通の特徴とし，種々の臓器で報告されてきた．神経領域では下垂体炎や肥厚性硬膜炎が知られていたが，新たにIgG4-RDがニューロパチーでもみられることを明らか …
NAID 130004921198