sumatriptan

出典: meddic

スマトリプタン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/15 09:12:18」(JST)

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英文文献

  • Treatment adherence among new triptan users: a 2-year cohort study in Taiwan.
  • Chen TB, Chen YT, Fuh JL, Tang CH, Wang SJ.
  • The journal of headache and pain.J Headache Pain.2014 Aug 12;15(1):48. [Epub ahead of print]
  • BACKGROUND: The persistence of triptan use among newly prescribed users is low in the United States and European countries. However, triptan refill patterns in Asian primary care practices have not been well described.METHODS: Data from the National Health Insurance Research Database in Taiwan were
  • PMID 25117594
  • Menstrual migraine: an updated review on hormonal causes, prophylaxis and treatment.
  • Silberstein S1, Patel S.
  • Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2014 Aug 6:1-8. [Epub ahead of print]
  • Introduction: In this article, we will discuss pure menstrual migraine without aura (PMM) and menstrually related migraine without aura (MRM). Depending on the frequency and severity of their attacks, patients with PMM will likely need an acute treatment and/or short-term preventive plan. Of note, w
  • PMID 25100506
  • [Therapy of trigeminal autonomic headaches].
  • Jürgens TP.
  • Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz.2014 Aug;57(8):983-95. doi: 10.1007/s00103-014-2003-7.
  • Trigeminal autonomic cephalgias (TAC) are characterized by severe and strictly unilateral headaches with a frontotemporal and periorbital preponderance in combination with ipsilateral cranial autonomic symptoms, such as lacrimation, conjunctival injection, rhinorrhea, nasal congestion, and restlessn
  • PMID 25005009

和文文献

  • Headache Management in Neurosurgical Practice
  • 間中 信也
  • Japanese Journal of Neurosurgery 21(10), 771-778, 2012
  • … five brands including sumatriptan, zolmitriptan, eletriptan, rizatriptan and naratriptan are presently available in Japan. …
  • NAID 130001929025
  • Monitoring cortical hemodynamic changes after sumatriptan injection during migraine attack by near-infrared spectroscopy
  • WATANABE Yuka,TANAKA Hideaki,DAN Ippeita,SAKURAI Kunihiko,KIMOTO Kazuhito,TAKASHIMA Ryotaro,HIRATA Koichi
  • Neuroscience research : the official journal of the Japan Neuroscience Society 69(1), 60-66, 2011-01-01
  • NAID 10028190214
  • Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate
  • Sheshala Ravi,Khan Nurzalina,Darwis Yusrida
  • Chemical and Pharmaceutical Bulletin 59(8), 920-928, 2011
  • … The aims of the present research were to mask the intensely bitter taste of sumatriptan succinate and to formulate orally disintegrating tablets (ODTs) of the taste masked drug. … Taste masking was performed by coating sumatriptan succinate with Eudragit EPO using spray drying technique. …
  • NAID 130000960921

関連リンク

Sumatriptan is a synthetic drug belonging to the triptan class, used for the treatment of migraine headaches. Structurally, it is an analog of the naturally occurring neuro-active alkaloids dimethyltryptamine (DMT), bufotenine, and ...
Find a comprehensive guide to possible side effects when taking Imitrex ( Sumatriptan Succinate) for Professionals, Patients, and Caregivers.

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★リンクテーブル★
リンク元セロトニン受容体」「スマトリプタン
拡張検索sumatriptan succinate

セロトニン受容体」

  [★]

serotonin receptor
5-HT受容体
セロトニン


セロトニン受容体 (GOO.300)

サブタイプ シグナル 局在 機能 生体反応 選択的作動薬 選択的阻害薬
5-HT1A AC縫線核
海馬
自己受容体   8-OH-DPAT
tandospirone
 
5-HT1B AC鉤状回
黒質
自己受容体      
5-HT1C AC脳血管 血管収縮      
5-HT1D AC皮質
線条体
-   sumatriptan  
5-HT1E AC脳および末梢 -      
5-HT2A PLC血小板
平滑筋
大脳皮質
血小板凝集
収縮
神経興奮
  α-methtl-5-HT, DOI スピペロン
ketanserin
5-HT2B PLC胃底 収縮   α-methtl-5-HT, DOI  
5-HT2C PLC脈絡叢 -   α-methtl-5-HT, DOI  
5-HT3 ion channel 末梢神経 神経興奮   2-methyl-5-HT ondansetron
tropisetron
腸神経細胞 嘔吐
最後野
5-HT4 AC胃腸管 神経興奮   renzapride  
海馬 認知
5-HT5A AC         
5-HT5B ? 海馬      
5-HT6 AC線条体      
5-HT7 AC脳下垂体
小腸
     
  • 5-HT3受容体はリガンドの結合により開閉してNa+, K+の等価に関わる。ニコチン性受容体に似ている。(GOO.299)

セロトニン受容体

  • 5-HT1A
  • リガンドの結合に共役してK+チャネルを開口→過分極→電位依存性カルシウムチャネルを抑制
  • 脳幹縫線核、に局在
鎮静作用をしめすセロトニン作動性ニューロンが存在
  • somatodendritic 5-HT1A autoreceptors descrease raphe cell fireing when activated by 5-HT released from axon collaterals of the same or adjacent neurons. (GOO.301)
  • 5-HT1B
  • 5-HT1C
  • 5-HT1D
  • 5-HT1E
  • 5-HT2A
  • 5-HT2B
  • 5-HT2C
  • 5-HT5A
  • 5-HT5B
  • 5-HT6受容体
  • 5-HT7受容体


スマトリプタン」

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sumatriptan
コハク酸スマトリプタン sumatriptan succinate
イミグランImitrex
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sumatriptan succinate」

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