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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/26 10:03:42」(JST)

Sulfatidosis is a form of lysosomal storage disease resulting in a proliferation of sulfatide.

Causes

It is caused by a genetic insufficiency of sulfatase enzymes.^[1]

Metachromatic leukodystrophy and multiple sulfatase deficiency are classified as sulfatidoses.^[2]^[3]

^ "Definition: sulfatidosis from Online Medical Dictionary".
^ Sulfatidosis at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 161. ISBN 0-7216-0187-1.

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Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells.

Pituch KC1, Moyano AL1, Lopez-Rosas A1, Marottoli FM1, Li G2, Hu C2, van Breemen R2, Månsson JE3, Givogri MI4.
The Journal of biological chemistry.J Biol Chem.2015 Mar 13;290(11):7040-53. doi: 10.1074/jbc.M115.636498. Epub 2015 Jan 20.
The membrane-bound receptor for platelet-derived growth factor A (PDGFRα) is crucial for controlling the production of oligodendrocytes (OLs) for myelination, but regulation of its activity during OL differentiation is largely unknown. We have examined the effect of increased sulfated content of ga
PMID 25605750

Spiral ganglion degeneration and hearing loss as a consequence of satellite cell death in saposin B-deficient mice.

Akil O1, Sun Y2, Vijayakumar S3, Zhang W4, Ku T1, Lee CK1, Jones S3, Grabowski GA5, Lustig LR6.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 Feb 18;35(7):3263-75. doi: 10.1523/JNEUROSCI.3920-13.2015.
Saposin B (Sap B) is an essential activator protein for arylsulfatase A in the hydrolysis of sulfatide, a lipid component of myelin. To study Sap B's role in hearing and balance, a Sap B-deficient (B(-/-)) mouse was evaluated. At both light and electron microscopy (EM) levels, inclusion body accumul
PMID 25698761

[Analysis of phenotype and genotype in a family with late infantile metachromatic leukodystrophy].

Yang J1, Cao J, Li Y, Zheng H, Li J, Liang Y, Liu Z, Wang L, Zhang C.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.Zhonghua Yi Xue Yi Chuan Xue Za Zhi.2014 Oct;31(5):615-8. doi: 10.3760/cma.j.issn.1003-9406.2014.01.017.
OBJECTIVE: To study genotype-phenotype correlation of a family with late infantile metachromatic leukodystrophy(MLD).METHODS: Clinical data were collected and ARSA gene was tested by PCR and sequencing in a pedigree.RESULTS: The male proband onset with walking dysfunction at 19 months, arylsulfatase
PMID 25297594