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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/01 02:39:13」(JST)

Sulfaphenazole (or sulfafenazol) is a sulfonamide antibacterial.^[1]

References

^ Browne, S. G. (1961). "Trial of a long-acting sulfonamide sulfaphenazole (Orisul, Ciba), in the treatment of leprosy". International journal of Leprosy 29: 502–505. PMID 13873771. edit

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Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Breast Cancer Resistance Protein Activities and Expression to Increased Oral Glibenclamide Exposure in Rats with Streptozotocin-Induced Diabetes Mellitus.

Liu H, Liu L, Li J, Mei D, Duan R, Hu N, Guo H, Zhong Z, Liu X.SourceKey Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. xdliu@cpu.edu.cn.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Jun;40(6):1104-12. Epub 2012 Mar 5.
The purpose of this study was to evaluate the contributions of impaired cytochrome P450 and breast cancer resistance protein (BCRP) activity and expression to drug pharmacokinetics under diabetic conditions. Diabetes was induced in rats with the intraperitoneal administration of streptozocin. Gliben
PMID 22393122

Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).

Vestergren AS, Zlabek V, Pickova J, Zamaratskaia G.SourceDepartment of Food Science, BioCenter, Swedish University of Agricultural Sciences, 750 07, Uppsala, Sweden.
Molecular biology reports.Mol Biol Rep.2012 Jun;39(6):6867-73. Epub 2012 Feb 5.
Metabolic transformations of two substrates for human cytochrome P450 (CYP450) 2C9, tolbutamide and diclofenac, were investigated in hepatic microsomes from Atlantic salmon (Salmo salar L.). Tolbutamide hydroxylation followed Michaelis-Menten kinetics. Mean apparent Michaelis-Menten constant (K(m))
PMID 22311023

Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia–Reperfusion by Suppressing the Expression of BimEL and Noxa

Increased Expression of Drug-metabolizing Enzymes in Human Hepatocarcinoma FLC-4 Cells Cultured on Micro-space Cell Culture Plates

リンク元	「sulfafenazol」「スルファフェナゾール」

Sulfaphenazole
Systematic (IUPAC) name
	4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	526-08-9
ATC code	J01ED08 S01AB05 QJ01EQ08
PubChem	CID 5335
DrugBank	DB06729
ChemSpider	5144
UNII	0J8L4V3F81
KEGG	D01954
ChEMBL	CHEMBL1109
Chemical data
Formula	C15H14N4O2S
Molecular mass	314.363 g/mol
	SMILES O=S(=O)(c1ccc(N)cc1)Nc3ccnn3c2ccccc2;
	InChI InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2 ; Key:QWCJHSGMANYXCW-UHFFFAOYSA-N ;
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