スルファメトキシピリダジン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/22 17:45:33」(JST)
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Sulfamethoxypyridazine
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Systematic (IUPAC) name |
4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
80-35-3 N |
ATC code |
J01ED05 (WHO) QJ01EQ15 (WHO) |
PubChem |
CID 5330 |
ChemSpider |
5139 Y |
UNII |
T034E4NS2Z Y |
KEGG |
D02439 Y |
ChEBI |
CHEBI:102516 Y |
ChEMBL |
CHEMBL268869 Y |
Chemical data |
Formula |
C11H12N4O3S |
Molar mass |
280.304 g/mol |
SMILES
-
O=S(=O)(Nc1nnc(OC)cc1)c2ccc(N)cc2
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InChI
-
InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) Y
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Key:VLYWMPOKSSWJAL-UHFFFAOYSA-N Y
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NY (what is this?) (verify) |
Sulfamethoxypyridazine is a sulfonamide antibacterial.
It is prescribed for vaginal irritation, and severe acute thrush.
It is also used in the treatment of Dermatitis herpetiformis, where it is an alternative therapy to Dapsone.
Sulfamethoxypyridazine is supplied as 500mg tablets.
Antibacterials: nucleic acid inhibitors (J01E, J01M)
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Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
|
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Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
|
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Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
|
|
Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
|
|
Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
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Combinations |
- Trimethoprim/sulfamethoxazole#
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|
|
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
1st g. |
- Cinoxacin‡
- Flumequine‡
- Nalidixic acid‡
- Oxolinic acid‡
- Pipemidic acid‡
- Piromidic acid‡
- Rosoxacin‡
|
|
Fluoro-
quinolones |
2nd g. |
- Ciprofloxacin#
- Ofloxacin
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin‡
- Nadifloxacin‡
- Norfloxacin‡
- Pefloxacin‡
- Rufloxacin‡
|
|
3rd g. |
- Levofloxacin
- Balofloxacin‡
- Grepafloxacin‡
- Pazufloxacin‡
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin‡
|
|
4th g. |
- Besifloxacin
- Gatifloxacin
- Finafloxacin
- Gemifloxacin
- Moxifloxacin
- Clinafloxacin†
- Garenoxacin‡
- Prulifloxacin‡
- Sitafloxacin‡
- Trovafloxacin‡/Alatrofloxacin‡
|
|
Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
|
|
|
Newer non-fluorinated |
|
|
Related (DG) |
- Aminocoumarins: Novobiocin
|
|
|
Anaerobic DNA
inhibitors |
Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
|
|
Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
|
|
|
RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
- Rifalazil§
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
UpToDate Contents
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English Journal
- Fabrication of 2D nanosheet through self assembly behavior of sulfamethoxypyridazine inclusion complexes with α- and β-cyclodextrins.
- Rajendiran N1, Venkatesh G2, Mohandass T2.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Apr 5;123:158-66. doi: 10.1016/j.saa.2013.12.053. Epub 2013 Dec 18.
- A 2D nanosheet was fabricated through the supramolecular self assembly of sulfamethoxypyridazine (SMP) and β-cyclodextrin (β-CD) inclusion complexes. HRTEM image exhibited 2D nanosheet morphology with a length of 1200mm and the sheet thickness of 60mm. It is noted that the nanosheet did not form a
- PMID 24394532
- Biocompatibility and antibacterial activity of photolytic products of sulfonamides.
- Zessel K1, Mohring S2, Hamscher G3, Kietzmann M4, Stahl J5.
- Chemosphere.Chemosphere.2014 Apr;100:167-74. doi: 10.1016/j.chemosphere.2013.11.038. Epub 2013 Dec 8.
- BACKGROUND: This study assessed the photochemical fate of nine sulfonamides (sulfamerazine, sulfanilamide, sulfamethoxypyridazine, sulfamethoxazole, sulfachloropyridazine, sulfamethazine, sulfadiazine, sulfathiazole and sulfadimethoxine) during a 6h irradiation period with UVA/UVB-light and UVA-ligh
- PMID 24321335
- Detection of veterinary drug residues in surface waters collected nearby farming areas in Galicia, North of Spain.
- Iglesias A1, Nebot C, Vázquez BI, Miranda JM, Abuín CM, Cepeda A.
- Environmental science and pollution research international.Environ Sci Pollut Res Int.2014 Feb;21(3):2367-77. doi: 10.1007/s11356-013-2142-7. Epub 2013 Sep 26.
- The occurrence of pharmaceuticals in the aquatic environment has become a matter of concern in the last decade due to potential risks posed to non-target organisms and the potential for unintended human exposure via food chain. This concern has been driven by a high detection frequency for drugs in
- PMID 24068562
Japanese Journal
- Chameleonic Effect of Sulfanilamide and Sulfamethazine in Solvent Mixtures. Solubility Curves with Two Maxima
- BUSTAMANTE Pilar,OCHOA Rocio,REILLO Aurora,ESCALERA Josefa-Begona
- Chemical & pharmaceutical bulletin 42(5), 1129-1133, 1994-05-15
- … The equation is also able to predict the solubility curve of sulfamethoxypyridazine. …
- NAID 110003631097
- サルファ剤の非水溶媒中における過塩素酸滴定 : 局方薬品の非水滴定(第4報)
- 朝日 豊,田中 正己,杉本 真弓
- 分析化学 40(12), 889-893, 1991-12-05
- サルファ剤(H_2NC_6H_4SO_2NHR)14種を氷酢酸, 無水酢酸, アセトニトリル, ジオキサンなど非水溶媒中, 過塩素酸で電位差滴定する方法を検討した.スルファメチゾールなどRの塩基性が弱い場合(8件)は氷酢酸(アセトニトリル)中でNH_2を滴定する方法がよかった.スルファモノメトキシンなどRの塩基性が強い場合(6件)は無水酢酸中でNH_2をアセチル化しRを滴定する方法がよかった.
- NAID 110002906214
- サーモスプレイLC-MSによる食肉中のサルファ剤の一斉分析
- 堀江 正一,斉藤 貢一,星野 庸二,能勢 憲英,寺 正成,橘和 丘陽,中澤 裕之,山根 靖弘
- 衛生化学 36(4), 283-289, 1990-08-31
- … A thermospray high-performance liquid chromatographic-mass spectrometric (LC-MS) method has been developed for the analysis of sulfonamides such as sulfachlorpyridazine, sulfadiazine, sulfadimethoxine, sulfadimidine, sulfadoxine, sulfamerazine, sulfamethoxazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfaquinoxaline, sulfathiazole and sulfisomidine. …
- NAID 110003643677
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- Scientific Experts, Publications, Research Topics about sulfamethoxypyridazine ... ..These results show that the chameleonic effect can be described in a quantitative way in terms of Lewis acid-base interactions; this approach can ...
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