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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/01 18:28:40」(JST)

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Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.^[2]^[3] There are only two countries in which it is currently still marketed: Thailand and Ireland.^[3]

Synthesis

Sulfalene synthesis: GB 928151 U.S. Patent 3,098,069 ^[4]

References

^ ^a ^b ^c ^d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
^ DrugBank DB00664
^ ^a ^b Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.
^ Camerino, B.; Palamidessi, G., Gazz. Chim. Ital., (1960) 90, 1815.

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English Journal

Development of a simple, rapid, and robust liquid chromatographic method for the simultaneous determination of sulfalene, sulfadoxine, and pyrimethamine in tablets.

Mwalwisi YH1, Hoellein L2, Kaale E3, Holzgrabe U4.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Sep 10;129:558-570. doi: 10.1016/j.jpba.2016.07.044. Epub 2016 Jul 30.
PMID 27505128

Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model.

Kawahara T1, Takahashi T, Oishi K, Tanaka H, Masuda M, Takahashi S, Takano M, Kawakami T, Fukushima K, Kanazawa H, Suzuki T.
Microbiology and immunology.Microbiol Immunol.2015 Jan;59(1):1-12. doi: 10.1111/1348-0421.12210.
PMID 25400245

Discovery of lipids from B. longum subsp. infantis using whole cell MALDI analysis.

Timmer MS1, Sauvageau J, Foster AJ, Ryan J, Lagutin K, Shaw O, Harper JL, Sims IM, Stocker BL.
The Journal of organic chemistry.J Org Chem.2014 Aug 15;79(16):7332-41. doi: 10.1021/jo501016c. Epub 2014 Aug 1.
PMID 25032516

Japanese Journal

非定型抗酸菌に関する研究:第10報非定型抗酸菌症の発生機序に関する一実験

結核 46(9), 365-366, 1971
NAID 130001416480

電量滴定による医薬品の分析(第2報) : スルファメトキシピラジンの電量滴定

藥學雜誌 89(4), 450-453, 1969-04-25
NAID 110003654089

Sulfamethoxypyrazine(Sulfalene)に関する研究

日本化学療法学会雑誌 16(6), 765-769, 1968-09
NAID 40017449538

Related Pictures

Sulfalene; Sulfamethoxypyrazine SULFAMETHOXYPYRAZINE product picture Sulfamethoxypyrazine;Sulfalene avantages 500 mg de sulfamethoxypyrazine Sulfamethoxypyrazine + Pyrimethamine 甲氧吡嗪，Sulfamethoxypyrazine等

★リンクテーブル★

リンク元	「スルファレン」「スルファメトキシピラジン」

「スルファレン」

Systematic (IUPAC) name
	4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Pharmacokinetic data
Protein binding	60 to 80%
Biological half-life	60 to 65 hours
Excretion	Urinary
Identifiers
CAS Registry Number	152-47-6
ATC code	J01ED02 QJ01EQ19
PubChem	CID: 9047
DrugBank	DB00664
ChemSpider	8695
UNII	T6BL4ZC15G
KEGG	D01216
Synonyms	Sulfametopyrazine
Chemical data
Formula	C11H12N4O3S
Molecular mass	280.304 g/mol
	SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2 ;
	InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) ; Key:KXRZBTAEDBELFD-UHFFFAOYSA-N ;
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