関: sulfalene

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/15 19:40:34」(JST)

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Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.^[2]^[3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.^[3]

It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.^[4]^[5]

References

^ ^a ^b ^c ^d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
^ DrugBank DB00664
^ ^a ^b Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.
^ Baruffa G. Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide. Trans R Soc Trop Med Hyg. 1966;60(2):222-4. PMID 5332105
^ Per prior citation, the first publication: Camerino B, Palamidessi G (1960) Derivati della parazina II. Sulfonamdopir (in Italian). Gazz Chim Ital 90:1802–1815

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English Journal

Nitrogen-14 nuclear quadrupole resonance spectroscopy: a promising analytical methodology for medicines authentication and counterfeit antimalarial analysis.

Barras J1, Murnane D, Althoefer K, Assi S, Rowe MD, Poplett IJ, Kyriakidou G, Smith JA.
Analytical chemistry.Anal Chem.2013 Mar 5;85(5):2746-53. doi: 10.1021/ac303267v. Epub 2013 Feb 20.
We report the detection and analysis of a suspected counterfeit sample of the antimalarial medicine Metakelfin through developing nitrogen-14 nuclear quadrupole resonance ((14)N NQR) spectroscopy at a quantitative level. The sensitivity of quadrupolar parameters to the solid-state chemical environme
PMID 23384229

Identification of isobaric amino-sulfonamides without prior separation.

Barry SJ1, Wolff JC.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2012 Feb 29;26(4):419-29. doi: 10.1002/rcm.6118.
RATIONALE: Direct analysis mass spectrometry (DAMS) techniques offer increased speed of analysis without the need for sample preparation or prior separation. A feature of these techniques is that all ionisable species will typically be analysed at the same time which makes the ability to distinguish
PMID 22279018

Design and synthesis of new N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes.

Boechat N1, Pinheiro LC, Santos-Filho OA, Silva IC.
Molecules (Basel, Switzerland).Molecules.2011 Sep 20;16(9):8083-97. doi: 10.3390/molecules16098083.
A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, ¹H-, ¹³C-, ¹�
PMID 21934646

Japanese Journal

実験的トキソプラズマ症の治療に関する基礎的研究:(II) マウスの急性および慢性トキソプラズマ症心筋内虫体に及ばすAcetylspiramycinとSulfa剤あるいは牛血清由来免疫賦活物質 (CSP-II) の併用効果

The Japanese Journal of Antibiotics 35(2), 362-368, 1982
NAID 130004130308

慢性薬剤起因性肝内胆汁うっ滞症の1剖検例:肝内胆管系に関する形態学的研究

肝臓 21(1), 55-62, 1980
NAID 130000875432

薬剤投与によるトキソプラズマRH株およびBeverley株の毒性を変える試み

熱帯医学 Tropical medicine 18(3), 113-124, 1976-09-30
NAID 120000918821

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リンク元	「スルファメトピラジン」「sulfalene」

「スルファメトピラジン」

Sulfalene
Systematic (IUPAC) name
	4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
Drugs.com	International Drug Names
Routes of; administration	Oral
Pharmacokinetic data
Protein binding	60 to 80%
Biological half-life	60 to 65 hours
Excretion	Urinary
Identifiers
CAS Number	152-47-6
ATC code	J01ED02 (WHO) QJ01EQ19 (WHO)
PubChem	CID 9047
DrugBank	DB00664
ChemSpider	8695
UNII	T6BL4ZC15G
KEGG	D01216
Synonyms	Sulfametopyrazine
Chemical data
Formula	C11H12N4O3S
Molar mass	280.304 g/mol
	SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2 ;
	InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) ; Key:KXRZBTAEDBELFD-UHFFFAOYSA-N ;
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