スルファメラジン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/06 05:26:11」(JST)
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (August 2014) |
Sulfamerazine
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| Systematic (IUPAC) name |
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4-amino-N-(4-methylpyrimidin-2-yl)
benzenesulfonamide
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Identifiers |
| CAS Registry Number |
127-79-7 Y |
| ATC code |
D06BA06 J01ED07 QJ01EQ17 |
| PubChem |
CID: 5325 |
| DrugBank |
DB01581 Y |
| ChemSpider |
5134 Y |
| UNII |
UR1SAB295F Y |
| KEGG |
D02435 Y |
| ChEBI |
CHEBI:102130 Y |
| ChEMBL |
CHEMBL438 Y |
| Chemical data |
| Formula |
C11H12N4O2S |
| Molecular mass |
264.305 g/mol |
SMILES
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O=S(=O)(Nc1nc(ccn1)C)c2ccc(N)cc2
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InChI
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InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) Y
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Key:QPPBRPIAZZHUNT-UHFFFAOYSA-N Y
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| Y (what is this?) (verify) |
Sulfamerazine is a sulfonamide antibacterial.
Contents
- 1 Synthesis
- 2 See also
- 3 References
- 4 External links
Synthesis
Sulfamerazine synthesis:
[1][2] U.S. Patent 2,378,813
See also
- Sulfadiazine
- Sulfamethazine
- Sulfamethizole
References
- ^ Roblin, R. O.; Williams, J. H.; Winnek, P. S.; English, J. P. (1940). "Chemotherapy. II. Some Sulfanilamido Heterocycles1". Journal of the American Chemical Society 62 (8): 2002. doi:10.1021/ja01865a027.
- ^ Sprague, J. M.; Kissinger, L. W.; Lincoln, R. M. (1941). "Sulfonamido Derivatives of Pyrimidines". Journal of the American Chemical Society 63 (11): 3028. doi:10.1021/ja01856a046.
External links
Media related to Sulfonamide antibiotics at Wikimedia Commons
- Sulfamerazine (DrugBank)
- Sulfamerazine (NIST)
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Antibiotics and chemotherapeutics for dermatological use (D06)
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| Antibiotics |
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Tetracycline and derivatives
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- Demeclocycline
- Chlortetracycline
- Oxytetracycline
- Tetracycline
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Others
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- Amphenicol: Chloramphenicol
- Aminoglycosides: Neomycin
- Gentamicin
- Amikacin
- Streptogramin: Virginiamycin
- other: Fusidic acid
- Bacitracin
- Tyrothricin
- Mupirocin
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| Chemotherapeutics |
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Sulfonamides
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- Silver sulfadiazine
- Sulfathiazole
- Mafenide
- Sulfamethizole
- Sulfanilamide
- Sulfamerazine
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Antivirals
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- Aciclovir
- Penciclovir
- Idoxuridine
- Edoxudine
- Imiquimod
- Resiquimod
- Podophyllotoxin
- Docosanol
- Tromantadine
- Inosine
- Lysozyme
- Ibacitabine
- Lysine
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Other
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- Ingenol mebutate
- Metronidazole
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Index of skin
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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| Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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Antibacterials: nucleic acid inhibitors (J01E, J01M)
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Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
| DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
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Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
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Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
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Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
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| Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
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| Combinations |
- Trimethoprim/sulfamethoxazole#
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Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
| 1st g. |
- Cinoxacin‡
- Flumequine‡
- Nalidixic acid‡
- Oxolinic acid‡
- Pipemidic acid‡
- Piromidic acid‡
- Rosoxacin‡
|
|
Fluoro-
quinolones |
| 2nd g. |
- Ciprofloxacin#
- Ofloxacin
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin‡
- Nadifloxacin‡
- Norfloxacin‡
- Pefloxacin‡
- Rufloxacin‡
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|
| 3rd g. |
- Levofloxacin
- Balofloxacin‡
- Grepafloxacin‡
- Pazufloxacin‡
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin‡
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| 4th g. |
- Besifloxacin
- Gatifloxacin
- Finafloxacin
- Gemifloxacin
- Moxifloxacin
- Clinafloxacin†
- Garenoxacin‡
- Prulifloxacin‡
- Sitafloxacin‡
- Trovafloxacin‡/Alatrofloxacin‡
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| Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
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| Related (DG) |
- Aminocoumarins: Novobiocin
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Anaerobic DNA
inhibitors |
| Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
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| Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
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|
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| RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
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|
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of bacterial disease
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| Description |
|
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| Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
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| Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
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UpToDate Contents
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English Journal
- Highly sensitive determination of sulfonamides in environmental water samples by sodium dodecylbenzene sulfonate enhanced micro-solid phase extraction combined with high performance liquid chromatography.
- Zhou Q1, Fang Z2.
- Talanta.Talanta.2015 Aug 15;141:170-4. doi: 10.1016/j.talanta.2015.04.016. Epub 2015 Apr 11.
- Sulfonamides are important antibiotics, and have achieved great applications. However they also impose serious threat on the environment and human health when they enter into environment by various ways. Present study developed a new determination method for six sulfonamides such as sulfadiazine, su
- PMID 25966398
- Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range.
- Bui DA1, Hauser PC2.
- Journal of chromatography. A.J Chromatogr A.2015 Jun 9. pii: S0021-9673(15)00821-3. doi: 10.1016/j.chroma.2015.06.005. [Epub ahead of print]
- A new absorbance detector for capillary electrophoresis featuring relatively high intensity light-emitting diodes as radiation sources and photodiodes for the deep-UV range was developed. The direct relationship of absorbance values and concentrations was obtained by emulating Lambert-Beer's law wit
- PMID 26091783
- Direct analysis of six antibiotics in wastewater samples using rapid high-performance liquid chromatography coupled with diode array detector: a chemometric study towards green analytical chemistry.
- Vosough M1, Rashvand M2, Esfahani HM2, Kargosha K2, Salemi A3.
- Talanta.Talanta.2015 Apr;135:7-17. doi: 10.1016/j.talanta.2014.12.036. Epub 2014 Dec 31.
- In this work, a rapid HPLC-DAD method has been developed for the analysis of six antibiotics (amoxicillin, metronidazole, sulfamethoxazole, ofloxacine, sulfadiazine and sulfamerazine) in the sewage treatment plant influent and effluent samples. Decreasing the chromatographic run time to less than 4
- PMID 25640119
Japanese Journal
- Polymorph Control of Sulfamerazine by Ultrasonic Irradiation
- Influence of crystal structure on the tableting properties of sulfamerazine polymorphs
Related Links
- sul·fa·mer·a·zine (sŭl'fă-mer'ă-zēn), One of the components of the triple sulfonamide mixtures. sulfamerazine a short-acting sulfonamide. ... Disclaimer All content on this website, including dictionary, thesaurus, literature, geography ...
- Description Sulfamerazine is a sulfonamide antibacterial. In vitro Sulfamerazine exhibits biexponential decay in water and triexponential decay in cyclodextrins solutions. Sulfamerazine shows remarkably upfield shift in the complexes ...
Related Pictures
![Sulfamerazine synthesis: [ 1 ] [ 2 ] U.S](https://1mg.info/0/i/4/0067.jpg)
